Target Details
| UniProt AC | P49841 |
|---|---|
| Gene Symbol | GSK3B |
| Protein Name | Glycogen synthase kinase-3 beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 2,206
- Clinical molecules 168
- Avg pChEMBL 7.19
KEGG Pathways (49)
- Alcoholic liver disease
- Alzheimer disease
- Axon guidance
- B cell receptor signaling pathway
- Basal cell carcinoma
- Breast cancer
- Cadherin signaling
- Cell cycle
- Chemokine signaling pathway
- Colorectal cancer
- Cushing syndrome
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endometrial cancer
- ErbB signaling pathway
- Focal adhesion
- Gastric cancer
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hepatitis C
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human cytomegalovirus infection
- Human papillomavirus infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- Melanogenesis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Prion disease
- Prolactin signaling pathway
- Prostate cancer
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- T cell receptor signaling pathway
- Thyroid hormone signaling pathway
- Wnt signaling pathway
- Yersinia infection
- mTOR signaling pathway
Active Molecules (2,206)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RPGZQOOZHIEPJW
|
10.3 | Kd | 18 | — | |
ITOKNBPWGKEKPE
|
10.2 | IC50 | 2 | — | |
KNTODVAJZPLTBO
|
10.0 | IC50 | 4 | — | |
NCMRFSCEYJSKBH
|
10.0 | IC50 | 2 | — | |
KBVGRKCRBVWRQG
|
9.8 | IC50 | 2 | — | |
KOZNFQBNKITETG
|
9.8 | IC50 | 3 | — | |
QLGFITMILZNZCU
|
9.8 | IC50 | 2 | — | |
RPGZQOOZHIEPJW
|
9.8 | IC50 | 18 | — | |
GRYSKXCHMRRJMC
|
9.7 | IC50 | 2 | — | |
CEUSLGXUKGZQEI
|
9.7 | IC50 | 4 | — | |
FVAXCXHKGMJCLC
|
9.7 | IC50 | 4 | — | |
LLMXWBSEQIDLJG
|
9.7 | IC50 | 5 | — | |
NLDJCOJHSPZIKJ
|
9.7 | IC50 | 2 | — | |
XLQSAYDDCSLSMI
|
9.7 | Ki | 4 | — | |
HGBNXMUZCGQMOG
|
9.6 | IC50 | 4 | Yes | |
JRQHXUDMDHJKJZ
|
9.6 | IC50 | 2 | — | |
CJBGZDIMVHUOFK
|
9.5 | IC50 | 3 | — | |
LVHOFIUXRMSCFN
|
9.5 | Ki | 3 | Yes | |
NXMNKSKXYYCWRN
|
9.5 | IC50 | 3 | — | |
QCOOCCREMZWFAR
|
9.5 | IC50 | 3 | — | |
CJHNTUKGOQCWKH
|
9.5 | IC50 | 2 | — | |
AHIGNMOICQUWNV
|
9.5 | IC50 | 2 | — | |
QLWFPXXGZGCHFQ
|
9.5 | IC50 | 5 | — | |
QLGFITMILZNZCU
|
9.4 | IC50 | 2 | — | |
FHAJBKJRGWQUEK
|
9.4 | IC50 | 3 | — | |
GIIJLYUXUBPINQ
|
9.4 | IC50 | 3 | — | |
IEEBCOQGVKHYNM
|
9.4 | Ki | 4 | — | |
KZAWBYUYDLDFQY
|
9.4 | IC50 | 3 | — | |
PYDXUBHPYGQXBU
|
9.4 | IC50 | 3 | — | |
ZFJJSMUJXGVEEW
|
9.4 | IC50 | 2 | — | |
HNRLJYOIIWONBJ
|
9.3 | IC50 | 2 | — | |
AMZVBIHYDIQGRK
|
9.3 | Ki | 4 | — | |
ITOKNBPWGKEKPE
|
9.3 | IC50 | 2 | — | |
GAVPKFXPGFHFSY
|
9.3 | IC50 | 7 | Yes | |
NDFXSHIIGXVOKT
|
9.2 | IC50 | 2 | — | |
RPIKXGUGTPFFLU
|
9.2 | IC50 | 2 | — | |
GOMNONYNAWUWRB
|
9.2 | IC50 | 3 | — | |
MDZCSIDIPDZWKL
|
9.2 | IC50 | 2 | — | |
SPTOLQPXVZHQQD
|
9.2 | IC50 | 3 | — | |
SQNUUZACFPKMEP
|
9.2 | Ki | 2 | — | |
OVGGMGOSCMWAHF
|
9.2 | IC50 | 2 | — | |
XNDBMYMVADOBNP
|
9.2 | Ki | 4 | — | |
GSXIRUIKNXNLAP
|
9.2 | IC50 | 3 | — | |
QSEIHYMIZCHHFE
|
9.2 | IC50 | 2 | — | |
MENVSADYTLLXLP
|
9.1 | IC50 | 6 | — | |
NGSGOYFKVYMHAD
|
9.1 | IC50 | 2 | — | |
SDUBOUUIXINQQG
|
9.1 | Ki | 3 | — | |
NBSJZWFDNFWQDN
|
9.1 | IC50 | 29 | — | |
NPBXBJGEHIIUSM
|
9.1 | IC50 | 3 | — | |
PICRXLQEOXMWHZ
|
9.1 | IC50 | 3 | — |