Target Details
| UniProt AC | P46734 |
|---|---|
| Gene Symbol | MAP2K3 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 12
- Clinical molecules 4
- Avg pChEMBL 7.2
KEGG Pathways (22)
- Alcoholic liver disease
- Amyotrophic lateral sclerosis
- Cadherin signaling
- Cellular senescence
- Epstein-Barr virus infection
- Fc epsilon RI signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human immunodeficiency virus 1 infection
- Inflammatory mediator regulation of TRP channels
- Lipid and atherosclerosis
- MAPK signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pathways of neurodegeneration - multiple diseases
- Rap1 signaling pathway
- Salmonella infection
- TNF signaling pathway
- Thermogenesis
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Yersinia infection
Active Molecules (12)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZCCPLJOKGAACRT
|
8.4 | Kd | 599 | — | |
YTNDIPNEFMPJKF
|
8.4 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
8.3 | IC50 | 408 | — | |
UIARLYUEJFELEN
|
8.3 | Kd | 289 | Yes | |
MFAQYJIYDMLAIM
|
7.0 | Kd | 130 | Yes | |
NHHQJBCNYHBUSI
|
7.0 | Kd | 220 | — | |
YYLKKYCXAOBSRM
|
6.8 | Kd | 191 | — | |
QQWUGDVOUVUTOY
|
6.8 | Kd | 231 | Yes | |
HDAJDNHIBCDLQF
|
6.5 | IC50 | 14 | — | |
GUBJNPWVIUFSTR
|
6.4 | Kd | 103 | — | |
HFNKQEVNSGCOJV
|
6.3 | Kd | 65 | — | |
HZTYDQRUAWIZRE
|
6.0 | Kd | 40 | Yes |