Target Details
| UniProt AC | P45985 |
|---|---|
| Gene Symbol | MAP2K4 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 4 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 31
- Clinical molecules 10
- Avg pChEMBL 6.65
KEGG Pathways (20)
- Alcoholic liver disease
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Relaxin signaling pathway
- Salmonella infection
- TNF signaling pathway
- Toll-like receptor signaling pathway
- Yersinia infection
Active Molecules (31)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
UPJZIJDYXTYCDV
|
8.8 | Kd | 5 | — | |
UIARLYUEJFELEN
|
8.4 | Kd | 289 | Yes | |
PKPLGKVAJMCSQQ
|
7.2 | IC50 | 2 | — | |
HKSZLNNOFSGOKW
|
7.2 | Kd | 408 | — | |
HKSZLNNOFSGOKW
|
7.2 | Kd | 213 | — | |
CPIXJBLUTUTAEN
|
7.1 | IC50 | 2 | — | |
YVQOYBIBWBAHKH
|
6.9 | IC50 | 12 | — | |
OGNOHOPSWWOASA
|
6.8 | IC50 | 3 | — | |
VWMJHAFYPMOMGF
|
6.8 | Kd | 15 | — | |
QQWUGDVOUVUTOY
|
6.8 | Kd | 231 | Yes | |
CZWJLLBPWLUINU
|
6.8 | IC50 | 10 | — | |
YZDJQTHVDDOVHR
|
6.7 | Kd | 23 | — | |
NHHQJBCNYHBUSI
|
6.7 | Kd | 220 | — | |
YYLKKYCXAOBSRM
|
6.6 | Kd | 191 | — | |
PBACTZXZNFJQGT
|
6.5 | IC50 | 4 | — | |
RNVLUCHCKZGJKL
|
6.5 | IC50 | 2 | — | |
ORHOFZHZKBMJDI
|
6.5 | IC50 | 2 | — | |
VAARYSWULJUGST
|
6.5 | Kd | 119 | Yes | |
CHYJUWDXSCFHON
|
6.4 | IC50 | 2 | — | |
NXWXUDHOUKWAQU
|
6.4 | Kd | 16 | — | |
TZBJGXHYKVUXJN
|
6.4 | IC50 | 12 | Yes | |
CUIHSIWYWATEQL
|
6.2 | Kd | 61 | Yes | |
KDKUVYLMPJIGKA
|
6.2 | Kd | 91 | Yes | |
WINHZLLDWRZWRT
|
6.2 | Kd | 201 | Yes | |
MFAQYJIYDMLAIM
|
6.1 | Kd | 130 | Yes | |
QKNBRNSGPNCARD
|
6.1 | IC50 | 9 | — | |
HZTYDQRUAWIZRE
|
6.0 | Kd | 40 | Yes | |
JCJAEEODSKNKTC
|
6.0 | IC50 | 6 | Yes | |
ZCBUQCWBWNUWSU
|
6.0 | Kd | 59 | — | |
MIFPZJRPCSILQA
|
6.0 | IC50 | 6 | — | |
ODPGGGTTYSGTGO
|
6.0 | Kd | 153 | — |