Target Details
| UniProt AC | P45984 |
|---|---|
| Gene Symbol | MAPK9 |
| Protein Name | Mitogen-activated protein kinase 9 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 676
- Clinical molecules 191
- Avg pChEMBL 6.96
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (676)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AWZFCQRICMFIES
|
6.0 | IC50 | 9 | Yes | |
PSHKZCQQNWMMBK
|
6.0 | IC50 | 2 | — | |
XYVNGBDEDFMYEK
|
6.0 | IC50 | 2 | Yes | |
HNFUPQXIBABEIU
|
6.0 | IC50 | 2 | Yes | |
HZYXRWDUVNONMO
|
6.0 | IC50 | 2 | — | |
KOZFSFOOLUUIGY
|
6.0 | Kd | 88 | Yes | |
UVXXVTKNDYEVAL
|
6.0 | IC50 | 2 | — | |
VSHQPGVRRHIKDU
|
6.0 | IC50 | 2 | — | |
AWJPVXSHMIELNJ
|
6.0 | Ki | 23 | — | |
BCNMJLRKWYKBBZ
|
6.0 | IC50 | 4 | — | |
DPYBBGZWQJVQMB
|
6.0 | IC50 | 2 | Yes | |
DZSUJUOJJJCWGG
|
6.0 | Ki | 55 | Yes | |
HJYHJYGXRBYDIG
|
6.0 | Ki | 23 | — | |
HXHAJRMTJXHJJZ
|
6.0 | Ki | 52 | Yes | |
IGGNAIYXGIUMQZ
|
6.0 | Ki | 5 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
MLDQJTXFUGDVEO
|
6.0 | IC50 | 85 | Yes | |
OIDZQWOKVFYZSD
|
6.0 | Ki | 8 | — | |
OVGNDEJGXTVQKL
|
6.0 | IC50 | 5 | — | |
PMNWPSRSXHKOQI
|
6.0 | Kd | 3 | — | |
USBKPWRTJAXTBS
|
6.0 | IC50 | 16 | Yes | |
VCFDMLBPASGZTP
|
6.0 | Ki | 38 | — | |
WNJPSYHJVTYTBP
|
6.0 | Ki | 9 | — | |
ZJAHDRFLBKWZPM
|
6.0 | Ki | 2 | — |