Target Details
| UniProt AC | P45984 |
|---|---|
| Gene Symbol | MAPK9 |
| Protein Name | Mitogen-activated protein kinase 9 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 676
- Clinical molecules 191
- Avg pChEMBL 6.96
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (676)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VYQHPOVDIRILEA
|
6.2 | IC50 | 3 | Yes | |
CVPRZXVWXVVWIX
|
6.1 | IC50 | 2 | — | |
BAEFMUUEJBUVJL
|
6.1 | IC50 | 5 | — | |
BTJOSZCOBPWUOW
|
6.1 | Kd | 3 | — | |
HKSZLNNOFSGOKW
|
6.1 | IC50 | 408 | — | |
KEISYNODBQSSPV
|
6.1 | IC50 | 2 | — | |
OSVUGUHRKMMBSE
|
6.1 | Kd | 170 | — | |
TUFCSONOIRZJQY
|
6.1 | IC50 | 2 | — | |
YONROWXRHUCUPV
|
6.1 | IC50 | 2 | — | |
PNTONLVXRZCBPB
|
6.1 | IC50 | 3 | Yes | |
CUTRCHHQYWQMFT
|
6.1 | IC50 | 2 | Yes | |
HDAJDNHIBCDLQF
|
6.1 | IC50 | 14 | — | |
MPULMLDKNWNYOT
|
6.1 | IC50 | 2 | — | |
AWKZEYXIJBNHRM
|
6.1 | Ki | 3 | — | |
BIKYDWLMTPRSQL
|
6.1 | Ki | 50 | — | |
DASFSPDIWCMVRW
|
6.1 | Ki | 21 | — | |
FPDLLNHKOIBFNW
|
6.1 | IC50 | 2 | — | |
GXFGHUNNGNQSMQ
|
6.1 | Ki | 19 | — | |
HHHWHXLLZCRLAO
|
6.1 | Ki | 5 | — | |
KNARVZUUCLIBGV
|
6.1 | Ki | 33 | — | |
LCGSWTFWYNYUKS
|
6.1 | Ki | 26 | — | |
LDNDTZTXPRCUJS
|
6.1 | Ki | 2 | — | |
NRGYZNJPCGRCLV
|
6.1 | Ki | 52 | — | |
PQRCICYGWACMGJ
|
6.1 | Ki | 3 | — | |
QLDFAHVPALXKAU
|
6.1 | IC50 | 2 | — | |
RYYNGWLOYLRZLK
|
6.1 | Ki | 104 | — | |
UGEJLCNSVIVALC
|
6.1 | Ki | 41 | — | |
YWITWZUKNXWOSD
|
6.1 | Ki | 10 | — | |
ZRQXCQXWTLVASO
|
6.1 | Ki | 36 | — | |
FEGPYUXSDDPKOY
|
6.1 | IC50 | 5 | — | |
IQCBETQVXZDQOC
|
6.1 | IC50 | 2 | — | |
JIYYYSRFLXRKAB
|
6.1 | IC50 | 3 | Yes | |
LIWQYJBFPZCBRH
|
6.1 | IC50 | 2 | — | |
SRZUMCBVXNGXNY
|
6.1 | IC50 | 3 | — | |
WYBUPBYFJYBWQP
|
6.1 | IC50 | 2 | — | |
APPUPKYUHWUPCJ
|
6.1 | Kd | 3 | — | |
LXZLCVFQXWMBJR
|
6.1 | IC50 | 3 | Yes | |
MADKYDDGPHTDEP
|
6.1 | IC50 | 3 | — | |
PYUVRCPASPJQHH
|
6.1 | IC50 | 3 | Yes | |
QNABDSWBQJKBHK
|
6.1 | IC50 | 45 | — | |
SEENQGCHZHJXQG
|
6.1 | IC50 | 3 | — | |
ZOXNMYQEZBOPPT
|
6.1 | IC50 | 2 | — | |
GLFSGNWAZDGYBV
|
6.1 | IC50 | 2 | Yes | |
YAOWLMDOOICXCZ
|
6.1 | IC50 | 3 | Yes | |
DODXRPDCYJJXKJ
|
6.0 | IC50 | 2 | — | |
ICCHKYUWVDXHIK
|
6.0 | IC50 | 2 | — | |
CMJCXYNUCSMDBY
|
6.0 | Kd | 15 | — | |
OXYMFDZMUCACBM
|
6.0 | IC50 | 5 | — | |
XGDOIYPBCVRKPZ
|
6.0 | IC50 | 3 | — | |
JTVHPFGRRUKYMR
|
6.0 | IC50 | 3 | Yes |