Target Details
| UniProt AC | P45984 |
|---|---|
| Gene Symbol | MAPK9 |
| Protein Name | Mitogen-activated protein kinase 9 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 676
- Clinical molecules 191
- Avg pChEMBL 6.96
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (676)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IUWWRSQCDUQDEZ
|
10.2 | IC50 | 8 | — | |
IUWWRSQCDUQDEZ
|
10.2 | IC50 | 9 | — | |
DXAACKOYNNQYHC
|
9.6 | IC50 | 3 | — | |
OCZDPFMSAKKNRH
|
9.3 | IC50 | 3 | — | |
UWRMCLKRRNBFQO
|
9.2 | IC50 | 2 | — | |
QKNUVGWNFPSQJF
|
9.2 | IC50 | 2 | — | |
KLJACMJXBFSIJH
|
9.0 | IC50 | 2 | — | |
RTLWBOSFRJIHRI
|
9.0 | IC50 | 2 | — | |
WKRRYRSXQAPECL
|
9.0 | IC50 | 2 | — | |
YMIJUBCSOKSFRU
|
8.8 | Ki | 87 | — | |
LUFRTLQRKNBFAZ
|
8.7 | IC50 | 3 | — | |
KAZMQKPLIPWQNO
|
8.7 | IC50 | 6 | Yes | |
LHIXDFRNBOEPTF
|
8.7 | IC50 | 2 | — | |
RADRIIWGHYFWPP
|
8.7 | IC50 | 4 | — | |
VQQDOYPJOLNJQP
|
8.7 | IC50 | 2 | — | |
BPAKBBJBLXVUPC
|
8.7 | IC50 | 2 | — | |
GCBJDOWIQHMCMR
|
8.6 | Ki | 84 | — | |
QVAFACIVQBAMNP
|
8.6 | IC50 | 2 | — | |
IFVVYANOPWLAHG
|
8.5 | IC50 | 3 | — | |
KLPFPTSVYVEKOL
|
8.5 | IC50 | 4 | Yes | |
CSDDCHPGQGWRLI
|
8.4 | Ki | 5 | Yes | |
DHEWUQRYCYPWDW
|
8.4 | IC50 | 2 | — | |
KQMPRSZTUSSXND
|
8.4 | Ki | 4 | Yes | |
LYNBNVBMAGDJRW
|
8.4 | Ki | 81 | — | |
NBGQUDQYBPKDMG
|
8.4 | IC50 | 2 | — | |
CRWXJGJNJZPMRW
|
8.3 | IC50 | 3 | Yes | |
DNQLQDZACRVRIW
|
8.3 | IC50 | 2 | — | |
FILBHLMAZQOSRM
|
8.3 | IC50 | 2 | — | |
FVONQZQMUHLATI
|
8.3 | IC50 | 2 | — | |
HBVKYTFESIYABI
|
8.3 | IC50 | 2 | — | |
LHIXDFRNBOEPTF
|
8.3 | IC50 | 3 | — | |
MHWHPWMWKYXCRJ
|
8.3 | Ki | 32 | — | |
PBJRYHNRBNLHDF
|
8.3 | IC50 | 2 | — | |
RXDOUBRAWQLAGH
|
8.3 | IC50 | 3 | — | |
ZQUSFAUAYSEREK
|
8.3 | IC50 | 9 | Yes | |
ZYWJPJYYTUCZHN
|
8.3 | IC50 | 3 | Yes | |
DNQLQDZACRVRIW
|
8.2 | IC50 | 2 | — | |
SZNPQONVZOSPLO
|
8.2 | Ki | 3 | Yes | |
HUXSWYWELGEQNC
|
8.2 | Ki | 5 | — | |
IYHNFVWLUSPIBF
|
8.2 | Ki | 4 | — | |
KBFBKKNSHPUFET
|
8.2 | Ki | 5 | — | |
MVJMMLFMPWITEJ
|
8.2 | Ki | 110 | — | |
IBGLGMOPHJQDJB
|
8.2 | IC50 | 5 | — | |
BITKACVYPQACTC
|
8.2 | IC50 | 2 | — | |
IBGLGMOPHJQDJB
|
8.2 | IC50 | 8 | Yes | |
MVCOAUNKQVWQHZ
|
8.1 | IC50 | 54 | Yes | |
VSVFDMDYNXAZHL
|
8.1 | IC50 | 4 | — | |
UJLHONOXXNLUDV
|
8.1 | IC50 | 3 | Yes | |
WNRCGOJLZOLSJN
|
8.1 | IC50 | 3 | Yes | |
PMKGMHMKOAVCLM
|
8.1 | IC50 | 2 | — |