Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FVONQZQMUHLATI
|
6.8 | IC50 | 2 | — | |
IFPPYSWJNWHOLQ
|
6.8 | Ki | 52 | Yes | |
JJGSOVIZOMZMCS
|
6.8 | Ki | 35 | — | |
LOLPPWBBNUVNQZ
|
6.8 | Kd | 97 | Yes | |
LRVSISWQSCNQKL
|
6.8 | IC50 | 3 | Yes | |
MGNQNQOSSLCUFP
|
6.8 | Ki | 12 | — | |
NLNVCPSZHKGGDI
|
6.8 | Ki | 2 | — | |
OFGKHGRQQKNHAV
|
6.8 | Ki | 5 | — | |
QQWUGDVOUVUTOY
|
6.8 | Kd | 231 | Yes | |
QWBLRTCRXZETHI
|
6.8 | IC50 | 4 | — | |
ROIWTEBVYRJZEG
|
6.8 | IC50 | 3 | — | |
SFDUUFDVJHFBRB
|
6.8 | IC50 | 4 | — | |
SFFKUECRLQXXTN
|
6.8 | IC50 | 3 | — | |
WHVFDYQCAMPLMS
|
6.8 | Ki | 20 | Yes | |
XJJYJNMNYDNXNO
|
6.8 | Ki | 23 | — | |
YITXQMHAQVCANR
|
6.8 | IC50 | 3 | — | |
YONROWXRHUCUPV
|
6.8 | IC50 | 2 | — | |
MKHLHLAXBRMALM
|
6.8 | IC50 | 5 | — | |
CDHZIFBQYVOWNY
|
6.8 | IC50 | 3 | — | |
LHIXDFRNBOEPTF
|
6.8 | IC50 | 3 | — | |
DLNGCNBJNSICSI
|
6.8 | IC50 | 2 | — | |
JPKALYCLEWVYQU
|
6.8 | IC50 | 2 | — | |
QAPNZNFLFCTLFN
|
6.8 | IC50 | 2 | — | |
SIBBXUMRESEGRS
|
6.8 | IC50 | 3 | — | |
SRZUMCBVXNGXNY
|
6.8 | Ki | 3 | — | |
SVYQRMQQKKCGBE
|
6.8 | IC50 | 2 | Yes | |
XTFFMIPOKWLBRH
|
6.8 | IC50 | 3 | — | |
NMJXLTYBAJJXCO
|
6.8 | IC50 | 2 | — | |
FSGQLCRNDPQFNY
|
6.8 | IC50 | 3 | — | |
ZYPRSWQPKLBUQM
|
6.8 | IC50 | 3 | Yes | |
ABBHPRNOFIXTQU
|
6.7 | IC50 | 2 | — | |
DWBUOTPQOTXBPX
|
6.7 | IC50 | 2 | Yes | |
GFABXPYEGAFBKF
|
6.7 | IC50 | 2 | — | |
MXJAKLUXZXAYIC
|
6.7 | IC50 | 2 | — | |
NZNGPQXBCNZDCZ
|
6.7 | IC50 | 4 | Yes | |
OHYSHHMNDLYHFT
|
6.7 | IC50 | 2 | Yes | |
UXBBRWNEXINJRZ
|
6.7 | IC50 | 3 | — | |
BNSPEWBMGVWZFC
|
6.7 | IC50 | 7 | — | |
GDQXJQSQYMMKRA
|
6.7 | IC50 | 15 | — | |
JUNWGTQNFTURHK
|
6.7 | IC50 | 2 | — | |
JYYLVUFNAHSSFE
|
6.7 | Kd | 9 | — | |
OCGXTBFQADYTFI
|
6.7 | IC50 | 2 | — | |
DZYPGOHFOPGXTC
|
6.7 | IC50 | 2 | Yes | |
GNLAGGCSJGJECE
|
6.7 | Ki | 19 | Yes | |
HDRLAVNNWSHSOA
|
6.7 | Ki | 19 | — | |
HUXSWYWELGEQNC
|
6.7 | Ki | 5 | — | |
KBFBKKNSHPUFET
|
6.7 | Ki | 5 | — | |
NLUPJKQOKWBWFC
|
6.7 | Ki | 69 | — | |
PQNZVSVIDDXJQO
|
6.7 | IC50 | 3 | — | |
SLHHRPHWICLQNW
|
6.7 | IC50 | 2 | — |