Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
TTXQZIOMYONUEL
|
7.0 | IC50 | 3 | Yes | |
XTJZKALDRPVFSN
|
7.0 | IC50 | 5 | — | |
LAJAFFLJAJMYLK
|
7.0 | IC50 | 17 | — | |
YMHGDVJMGNXBIG
|
7.0 | IC50 | 2 | Yes | |
DODXRPDCYJJXKJ
|
6.9 | IC50 | 2 | — | |
GMIIXDTZSKOUIW
|
6.9 | IC50 | 2 | — | |
BLKGCBHORBGPFK
|
6.9 | IC50 | 2 | Yes | |
INUQHONAOUHTRF
|
6.9 | IC50 | 4 | — | |
KTJOPUTZKZLREI
|
6.9 | IC50 | 2 | — | |
MLEMAYBWCXSCBM
|
6.9 | IC50 | 3 | — | |
PBKYQJDUQYHRCL
|
6.9 | IC50 | 2 | — | |
VHYFUPDFEUQXIH
|
6.9 | IC50 | 2 | Yes | |
VYOMWAWIBCGOKB
|
6.9 | IC50 | 4 | — | |
CBHOUOHFUVTLFG
|
6.9 | IC50 | 3 | Yes | |
KXYHQCXHGCREEU
|
6.9 | IC50 | 2 | Yes | |
GCYXEGSPUDSZJY
|
6.9 | Ki | 82 | — | |
GLWXMYOBTQMICW
|
6.9 | IC50 | 3 | Yes | |
GURLMHMMTNQPMF
|
6.9 | IC50 | 3 | Yes | |
HMBDNAGIIDHKKM
|
6.9 | Ki | 9 | — | |
IJNGXROUMFEKDB
|
6.9 | Ki | 39 | — | |
IOBVCHJTLVPPBR
|
6.9 | Ki | 39 | — | |
JNXJKTXDSPWNRP
|
6.9 | Ki | 30 | — | |
NFMGZVPRGVERNN
|
6.9 | Ki | 44 | — | |
NHEQNFWGPSKRMJ
|
6.9 | Ki | 7 | — | |
OWRXHGAFWZFFCW
|
6.9 | Ki | 113 | — | |
RGNHKJWHFIPHIM
|
6.9 | Ki | 66 | — | |
VMSXLNMNMRCQPD
|
6.9 | IC50 | 3 | Yes | |
ZBAFXJXHSORURK
|
6.9 | IC50 | 4 | — | |
RHFIAUKMKYHHFA
|
6.9 | IC50 | 9 | — | |
FEENLVZHRIAWGM
|
6.9 | IC50 | 2 | — | |
JMOMBPSAYLGZAN
|
6.9 | IC50 | 2 | — | |
CVPRZXVWXVVWIX
|
6.8 | IC50 | 2 | — | |
FFPJBQIHDBPVHZ
|
6.8 | IC50 | 3 | Yes | |
MEFJFXHHHNDHEN
|
6.8 | IC50 | 2 | Yes | |
UPJZIJDYXTYCDV
|
6.8 | Kd | 5 | — | |
YZTLHDUNASRPOV
|
6.8 | IC50 | 2 | — | |
FKBQOEJUXLTCGJ
|
6.8 | IC50 | 3 | — | |
AVLYNJZZQYEFEA
|
6.8 | IC50 | 8 | Yes | |
DKZYXHCYPUVGAF
|
6.8 | Kd | 112 | — | |
KFIDJSXUJCJHQB
|
6.8 | IC50 | 6 | — | |
MADKYDDGPHTDEP
|
6.8 | Ki | 3 | — | |
MLIRIWBFADTRLZ
|
6.8 | IC50 | 4 | Yes | |
MXRSDWOBSNRDKJ
|
6.8 | IC50 | 2 | Yes | |
PMNWPSRSXHKOQI
|
6.8 | Kd | 3 | — | |
RCYPVQCPYKNSTG
|
6.8 | IC50 | 7 | — | |
RWOFIHYHMILOTJ
|
6.8 | IC50 | 3 | Yes | |
SAMLUEXYGUANPP
|
6.8 | IC50 | 3 | Yes | |
SPBVUOILOVHJPD
|
6.8 | IC50 | 3 | — | |
XJNGZIGUKNHSJB
|
6.8 | IC50 | 2 | — | |
ZDMNBFRGLJDTJG
|
6.8 | IC50 | 3 | — |