Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QWBLRTCRXZETHI
|
7.1 | IC50 | 5 | — | |
GLWXMYOBTQMICW
|
7.1 | IC50 | 3 | Yes | |
VTTJSUDCCDBRRF
|
7.1 | IC50 | 3 | Yes | |
YTNDEFNPJUZDTP
|
7.1 | IC50 | 3 | — | |
ACGBFWCBVIXTPZ
|
7.1 | IC50 | 3 | Yes | |
AEHOYSAJZSVRLQ
|
7.1 | IC50 | 2 | — | |
KDAMBQMCWSCLEM
|
7.1 | IC50 | 4 | — | |
RPBRKXHDLFDUJN
|
7.1 | IC50 | 2 | — | |
XRHSVYXJHZMCCY
|
7.1 | IC50 | 3 | Yes | |
FVONQZQMUHLATI
|
7.0 | IC50 | 2 | — | |
NJOQHORLRFTUGK
|
7.0 | IC50 | 2 | Yes | |
OOOZOACKEXWXQJ
|
7.0 | IC50 | 3 | Yes | |
BXZQZGKOTDCAKN
|
7.0 | IC50 | 3 | — | |
IBGLGMOPHJQDJB
|
7.0 | IC50 | 8 | Yes | |
JSDUDTFXRSCOHV
|
7.0 | IC50 | 4 | Yes | |
PLJKGPIWOOUPAJ
|
7.0 | IC50 | 3 | — | |
SGWLRDAOCLITOM
|
7.0 | IC50 | 7 | — | |
XVLIRDXMQGPGCW
|
7.0 | IC50 | 4 | Yes | |
YOOLXKXFWTXRHM
|
7.0 | IC50 | 2 | — | |
AHJILNZMMPJQIT
|
7.0 | IC50 | 2 | — | |
BBPWMHYCJRYYFV
|
7.0 | IC50 | 2 | — | |
BQWUBCRDJPIJAT
|
7.0 | IC50 | 10 | — | |
KLYSOWZEHKSGHP
|
7.0 | IC50 | 2 | — | |
NKFDCMFJEHBWMX
|
7.0 | IC50 | 2 | — | |
DNQLQDZACRVRIW
|
7.0 | IC50 | 2 | — | |
PNTONLVXRZCBPB
|
7.0 | IC50 | 3 | Yes | |
XVIMTHVVBGUFCB
|
7.0 | IC50 | 3 | Yes | |
RLTYMZOLUUHEKX
|
7.0 | IC50 | 2 | — | |
UNWYPVDZMQJENJ
|
7.0 | IC50 | 2 | Yes | |
ADMFLILDQJSEIK
|
7.0 | Ki | 72 | — | |
AHMHIFXJPSHHPH
|
7.0 | IC50 | 3 | Yes | |
HENCYENWBZRSLR
|
7.0 | Ki | 3 | — | |
HKSZLNNOFSGOKW
|
7.0 | Ki | 118 | — | |
IPPNJZWFNCNYSG
|
7.0 | IC50 | 3 | — | |
LJWSUGUZCIJVRS
|
7.0 | IC50 | 2 | Yes | |
ORQYRUZYGXLVJP
|
7.0 | IC50 | 2 | Yes | |
QCOULMVHIHJKFY
|
7.0 | Ki | 14 | — | |
QHYSKDAWIUFROA
|
7.0 | IC50 | 3 | Yes | |
XQHYPIHJXWTXPZ
|
7.0 | IC50 | 3 | Yes | |
YVLVTFFRFJLZON
|
7.0 | IC50 | 2 | — | |
BYCDZWGPIIHWFV
|
7.0 | IC50 | 2 | Yes | |
HQBDXBBDGWHRLC
|
7.0 | IC50 | 3 | Yes | |
KLRKVNKANBJQPN
|
7.0 | IC50 | 3 | — | |
PVBFXVLGPVXIGL
|
7.0 | IC50 | 2 | Yes | |
DVEYHFXOGUYFBU
|
7.0 | Kd | 5 | — | |
GELSCYBDXQYAMW
|
7.0 | IC50 | 2 | — | |
GXSSKILQHZMJFZ
|
7.0 | IC50 | 2 | — | |
JUCZVVOFLZHKJP
|
7.0 | IC50 | 2 | Yes | |
MBZXMVKLFZXZRB
|
7.0 | IC50 | 4 | — | |
PPHUYGGBTOACGL
|
7.0 | IC50 | 2 | Yes |