Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RIZAQRVECMBTPF
|
7.4 | IC50 | 2 | — | |
YMSORXXIQGLXBK
|
7.4 | IC50 | 2 | — | |
CITPEYUXGCJVRV
|
7.4 | IC50 | 2 | — | |
YIVZAUQCWPPATQ
|
7.4 | IC50 | 2 | — | |
ZDJZJCGVCBBGDA
|
7.4 | IC50 | 2 | Yes | |
CEJFYMKXALJHTD
|
7.3 | IC50 | 2 | Yes | |
HQZRYALYTLZTPR
|
7.3 | IC50 | 2 | — | |
WPHLFVIDUSHWHQ
|
7.3 | IC50 | 3 | Yes | |
YPUXXNJBUOZMOQ
|
7.3 | IC50 | 3 | Yes | |
YMIJUBCSOKSFRU
|
7.3 | IC50 | 87 | — | |
NRXSHWGSSDJHRF
|
7.3 | IC50 | 2 | — | |
QHGCJZAERWMAPE
|
7.3 | IC50 | 2 | — | |
XQLINAVACFUFEH
|
7.3 | IC50 | 4 | Yes | |
BGGSTZPBQKGLOJ
|
7.3 | IC50 | 3 | Yes | |
DGTWHZKHMUDXOY
|
7.3 | IC50 | 3 | Yes | |
MXRSDWOBSNRDKJ
|
7.3 | IC50 | 3 | Yes | |
POORMKCKTPLEDJ
|
7.3 | IC50 | 2 | — | |
SIBBXUMRESEGRS
|
7.3 | IC50 | 3 | — | |
XGDOIYPBCVRKPZ
|
7.3 | Ki | 3 | — | |
CDCZUMXTSTZOHL
|
7.3 | IC50 | 2 | — | |
BBJVUPIDQPSQJP
|
7.3 | IC50 | 2 | — | |
BILUVSXSPJVCMC
|
7.3 | IC50 | 2 | Yes | |
HGQHCYUSXPTRID
|
7.3 | IC50 | 4 | Yes | |
NSPCSJPGLMJDCZ
|
7.3 | IC50 | 2 | — | |
OTVCFDOYUHREFJ
|
7.3 | Ki | 26 | — | |
OVKIYZXGCCAIJG
|
7.3 | Ki | 6 | — | |
YEBFCGFMUQJOCV
|
7.3 | IC50 | 3 | Yes | |
DNQLQDZACRVRIW
|
7.3 | IC50 | 2 | — | |
FILBHLMAZQOSRM
|
7.3 | IC50 | 2 | — | |
QRCYLXLFEDYBSA
|
7.3 | IC50 | 2 | — | |
STRBDWNAMGZLQF
|
7.3 | IC50 | 2 | Yes | |
DAJHYBRFYWDMMM
|
7.3 | IC50 | 2 | Yes | |
JKCOWGOVZGAWTE
|
7.3 | IC50 | 2 | Yes | |
DPTBYUQHDCZBPL
|
7.3 | IC50 | 2 | — | |
GCBJDOWIQHMCMR
|
7.3 | IC50 | 84 | — | |
YKQSOUXCRZONQQ
|
7.3 | IC50 | 3 | Yes | |
JPCGBNVFAUAQSJ
|
7.2 | IC50 | 2 | — | |
NXXOMTBHZVIUJY
|
7.2 | IC50 | 2 | — | |
SGYOIXNBCYRZBZ
|
7.2 | IC50 | 4 | — | |
RJVBVUWFYMRHRI
|
7.2 | IC50 | 4 | Yes | |
RWVFVOHUWIBKDI
|
7.2 | IC50 | 2 | — | |
KXABTDJSBKARGL
|
7.2 | IC50 | 2 | — | |
WWHNHBJMWMVKHQ
|
7.2 | IC50 | 4 | Yes | |
YTPKEJXVUUNXRA
|
7.2 | IC50 | 4 | Yes | |
BITKACVYPQACTC
|
7.2 | IC50 | 2 | — | |
IBGLGMOPHJQDJB
|
7.2 | IC50 | 5 | — | |
LGTYWJCIEQTIIP
|
7.2 | IC50 | 3 | Yes | |
STNCBMGTCZRJPA
|
7.2 | IC50 | 2 | — | |
CCDFASODNLEBEJ
|
7.2 | IC50 | 3 | — | |
KRIUNPBAQZGFQA
|
7.2 | IC50 | 76 | — |