Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JMOMBPSAYLGZAN
|
7.8 | IC50 | 4 | Yes | |
KXNZPASCSDMHFQ
|
7.8 | IC50 | 5 | Yes | |
UDOITUAULPBVSE
|
7.8 | IC50 | 3 | Yes | |
UNUTTXCETMYXRD
|
7.8 | IC50 | 3 | Yes | |
JQCBHTULSVVPFD
|
7.8 | IC50 | 2 | — | |
MDCMULVKRBERMG
|
7.8 | IC50 | 2 | Yes | |
OOXCRLOLUWLQCN
|
7.8 | IC50 | 3 | Yes | |
VNDWQCSOSCCWIP
|
7.8 | Ki | 39 | Yes | |
BBDQLVRTKDEXCP
|
7.8 | IC50 | 2 | — | |
HDGJMVJJOYGVSR
|
7.8 | IC50 | 3 | Yes | |
MTFAYLZZDJGFGV
|
7.8 | IC50 | 2 | — | |
RTLWBOSFRJIHRI
|
7.8 | IC50 | 2 | — | |
FBMRMTHKZVMVDV
|
7.7 | IC50 | 3 | Yes | |
NIHQLDJHBMNLCZ
|
7.7 | IC50 | 3 | — | |
PTVSTQCTVOIQBP
|
7.7 | IC50 | 3 | — | |
CUIDQTVRAWOMCM
|
7.7 | IC50 | 7 | Yes | |
FWIAHWCHOKAIGH
|
7.7 | IC50 | 2 | — | |
VWIDJTODOGUOHO
|
7.7 | IC50 | 2 | — | |
VXVYIKQQPFNMED
|
7.7 | IC50 | 2 | Yes | |
PBJRYHNRBNLHDF
|
7.7 | IC50 | 2 | — | |
YLCVJWYVKHOSRE
|
7.7 | IC50 | 3 | Yes | |
FJVVBMGXZMJPOI
|
7.7 | IC50 | 3 | — | |
FJVVBMGXZMJPOI
|
7.7 | IC50 | 3 | — | |
FXBNFLKLXHFULB
|
7.7 | IC50 | 3 | Yes | |
UMIUXVPQKJLPJE
|
7.7 | IC50 | 4 | — | |
LZXLRJRSBFKIPI
|
7.7 | IC50 | 2 | — | |
BTJOSZCOBPWUOW
|
7.7 | Kd | 3 | — | |
QZVKYTBQVHAICK
|
7.7 | IC50 | 2 | Yes | |
ZYWJPJYYTUCZHN
|
7.7 | IC50 | 3 | Yes | |
GHLDPDGLXQCUNO
|
7.6 | IC50 | 3 | — | |
KUPWEENZVLBVNM
|
7.6 | IC50 | 3 | Yes | |
MUNGYPZWBYEXFS
|
7.6 | IC50 | 2 | — | |
VGQNDBIBHCCFKP
|
7.6 | IC50 | 3 | — | |
JSQNZBQJTQNCFK
|
7.6 | IC50 | 7 | — | |
XYMGBQVLIQVGBW
|
7.6 | IC50 | 2 | — | |
ZVDDPXIWKBBCQE
|
7.6 | IC50 | 3 | Yes | |
JCKBTQZTGPJTII
|
7.6 | IC50 | 3 | Yes | |
LYNBNVBMAGDJRW
|
7.6 | IC50 | 81 | — | |
SZBUKBINUVLFEL
|
7.6 | IC50 | 3 | Yes | |
LRUPHJAQKSRDNC
|
7.6 | IC50 | 2 | Yes | |
PXJCEFGMIBFUGI
|
7.6 | Ki | 3 | — | |
HSKWNXWRIGSISU
|
7.6 | IC50 | 2 | — | |
SHQNUFDSTNIIBP
|
7.6 | IC50 | 2 | Yes | |
UQNQOFSEHBSJGK
|
7.6 | IC50 | 2 | — | |
YFPHGGTUESKWNB
|
7.6 | IC50 | 2 | — | |
DTMZXHDQZQLTHA
|
7.5 | IC50 | 21 | — | |
GLVDZCDUMFNCFY
|
7.5 | IC50 | 3 | Yes | |
JDOKMDILBRSOLL
|
7.5 | IC50 | 3 | Yes | |
PRFQGCBPEYPZAY
|
7.5 | Ki | 3 | — | |
KKKRKRMVJRHDMG
|
7.5 | Kd | 14 | — |