Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NERJSNYOGGKVRR
|
6.2 | IC50 | 3 | — | |
VHPPODIXJOXBEV
|
6.2 | IC50 | 2 | Yes | |
XMMMCYBZGARUKP
|
6.2 | IC50 | 4 | — | |
ZOXNMYQEZBOPPT
|
6.2 | IC50 | 2 | — | |
AEYLJTAIDDIOBA
|
6.2 | Ki | 53 | — | |
CNOBUOFKVJJORP
|
6.2 | IC50 | 3 | — | |
IJRBJCMLWLFMIN
|
6.2 | Ki | 17 | — | |
JTOAKYPOVGNGDU
|
6.2 | IC50 | 3 | — | |
KDKUVYLMPJIGKA
|
6.2 | Ki | 91 | Yes | |
KNVOICXEDILAGT
|
6.2 | Ki | 17 | — | |
LQRGRVAYEDLPTG
|
6.2 | IC50 | 3 | Yes | |
QFHPSDWMERSJDZ
|
6.2 | IC50 | 4 | — | |
QMYPKGGBVVCXIE
|
6.2 | IC50 | 3 | — | |
QVNZKVACBBTKSL
|
6.2 | Ki | 38 | — | |
SYLTYCLPHHSEIJ
|
6.2 | Ki | 27 | — | |
VTRPSKIFOIGMRA
|
6.2 | IC50 | 3 | Yes | |
VUTLUBADCGINEP
|
6.2 | IC50 | 3 | — | |
VWACUNWBMWWMPJ
|
6.2 | Ki | 18 | — | |
WNJPSYHJVTYTBP
|
6.2 | Ki | 9 | — | |
XDJCLCLBSGGNKS
|
6.2 | Kd | 21 | — | |
XZXHXSATPCNXJR
|
6.2 | Kd | 165 | Yes | |
ZBYGBITZFKOQTA
|
6.2 | Ki | 18 | — | |
ZGZVRPRSFXRGCF
|
6.2 | Ki | 76 | — | |
ZKKDTKNDAYWGBN
|
6.2 | IC50 | 2 | Yes | |
ZRQXCQXWTLVASO
|
6.2 | Ki | 36 | — | |
BBVXPNDIVLNONK
|
6.2 | IC50 | 2 | Yes | |
HDODMRCSZYUGPO
|
6.2 | IC50 | 2 | — | |
HMLQTEJXWLWZJQ
|
6.2 | IC50 | 2 | — | |
CWJLAVRXVFHDSJ
|
6.2 | IC50 | 13 | — | |
ILUOKEKSMZBBQY
|
6.2 | IC50 | 3 | — | |
RXFZUHJHYNKIJF
|
6.2 | IC50 | 2 | Yes | |
HWSUJLBBZVSJFM
|
6.2 | IC50 | 3 | — | |
IOZQORJWOUBHKH
|
6.2 | IC50 | 3 | Yes | |
SCDOWHQVNDXVPB
|
6.2 | IC50 | 3 | Yes | |
XXPJQSSWRLLVEZ
|
6.2 | IC50 | 3 | — | |
CCEORUFGHAKXQE
|
6.2 | IC50 | 2 | Yes | |
PLVJKHRAOBBOKV
|
6.2 | IC50 | 3 | — | |
DDIMQPXLFWQMIR
|
6.1 | IC50 | 2 | — | |
LUZNKSCCMSULRH
|
6.1 | IC50 | 2 | — | |
PMKGMHMKOAVCLM
|
6.1 | IC50 | 2 | — | |
XLSYZSRXVVCHLS
|
6.1 | Kd | 48 | — | |
IBSOKDKEFQOSIY
|
6.1 | IC50 | 2 | Yes | |
PXOJJCCSYAVCPK
|
6.1 | IC50 | 3 | Yes | |
WTYOGZPSBLDMQY
|
6.1 | IC50 | 3 | Yes | |
CUFBUESSXCZHQS
|
6.1 | IC50 | 6 | — | |
JGHISYSDWKNXIA
|
6.1 | IC50 | 3 | — | |
QAJYGCFIHFNUML
|
6.1 | IC50 | 2 | Yes | |
AKWVKIGCMCHYJT
|
6.1 | Ki | 8 | — | |
GULNVBIIVHJZFA
|
6.1 | IC50 | 3 | Yes | |
JRLSUZIPUYDUKX
|
6.1 | Ki | 22 | — |