Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
IKVLVCWXKRSDND
|
6.3 | IC50 | 2 | Yes | |
MLIFNJABMANKEU
|
6.3 | IC50 | 9 | Yes | |
TWTIIHVYOGLKME
|
6.3 | Ki | 3 | Yes | |
VMQZTUVADKYPAR
|
6.3 | IC50 | 2 | Yes | |
NINIJRDUJSFATI
|
6.3 | IC50 | 3 | Yes | |
ODPGGGTTYSGTGO
|
6.3 | Kd | 153 | — | |
WHORUVUQHFFPNW
|
6.3 | IC50 | 2 | Yes | |
FILBHLMAZQOSRM
|
6.3 | IC50 | 2 | — | |
HHCBMISMPSAZBF
|
6.3 | IC50 | 23 | — | |
IMELNYJZDCCKFI
|
6.3 | IC50 | 2 | — | |
JXLXJDMNSAFVFP
|
6.3 | IC50 | 2 | Yes | |
YAJKXICRGUNBDU
|
6.3 | IC50 | 2 | — | |
FHGSYAFPJQQASV
|
6.3 | IC50 | 2 | Yes | |
ILTRIOQDZUXVFP
|
6.3 | IC50 | 2 | — | |
OMXIAXJGEYOQEC
|
6.3 | IC50 | 4 | Yes | |
QXNPNLLIZGVUPQ
|
6.3 | IC50 | 3 | Yes | |
CUIHSIWYWATEQL
|
6.3 | Ki | 61 | Yes | |
FTKWFHKMPQIDLM
|
6.3 | Ki | 5 | — | |
HJYHJYGXRBYDIG
|
6.3 | Ki | 23 | — | |
IILNBGZKSQQREW
|
6.3 | Ki | 6 | — | |
IPTSYCYNQJITNJ
|
6.3 | Ki | 12 | — | |
MYPQGCUDQYBJLG
|
6.3 | IC50 | 3 | Yes | |
QHKYPYXTTXKZST
|
6.3 | Ki | 28 | — | |
RQVKVJIRFKVPBF
|
6.3 | Ki | 13 | — | |
RYYNGWLOYLRZLK
|
6.3 | Ki | 104 | — | |
UCOWZARZLHNDKP
|
6.3 | Ki | 8 | — | |
VBILMRWSCQMTGR
|
6.3 | Ki | 2 | — | |
ZJWZDMQTDMVQQB
|
6.3 | IC50 | 3 | — | |
ZLLCVOJWNDZXIO
|
6.3 | Ki | 11 | — | |
KVDDBBDCWPLOFR
|
6.3 | IC50 | 3 | — | |
FAUFFPCPZRRZKT
|
6.3 | IC50 | 2 | — | |
FKBQPAXZYUEULP
|
6.3 | IC50 | 2 | Yes | |
GLLVHHZWPVUNED
|
6.3 | IC50 | 2 | — | |
IMARJVJNXLXPIX
|
6.3 | IC50 | 3 | — | |
NEBNIXUGANAKDR
|
6.3 | IC50 | 2 | Yes | |
OSVUGUHRKMMBSE
|
6.3 | Kd | 170 | — | |
SRJUPLSEYKRYTF
|
6.3 | IC50 | 2 | — | |
GTMGQYXCPKUZAD
|
6.3 | Ki | 6 | Yes | |
KOZFSFOOLUUIGY
|
6.3 | Kd | 88 | Yes | |
OBJNFLYHUXWUPF
|
6.3 | IC50 | 17 | — | |
PANZFUIIZSOBRK
|
6.2 | IC50 | 2 | — | |
APPUPKYUHWUPCJ
|
6.2 | Kd | 3 | — | |
CLCSSDBGIADDIH
|
6.2 | IC50 | 2 | — | |
DXAJWOOLPAIVJG
|
6.2 | IC50 | 3 | Yes | |
NGFCRLVABQTLPT
|
6.2 | IC50 | 3 | Yes | |
WRXMCDABCCZKSX
|
6.2 | IC50 | 2 | — | |
WXXPHDFRDIYFEP
|
6.2 | IC50 | 2 | — | |
YYLKKYCXAOBSRM
|
6.2 | Kd | 191 | — | |
ZFGJERKBORCEBU
|
6.2 | IC50 | 2 | Yes | |
DIUBLEYZTHWMDJ
|
6.2 | IC50 | 2 | Yes |