Target Details
| UniProt AC | P45983 |
|---|---|
| Gene Symbol | MAPK8 |
| Protein Name | Mitogen-activated protein kinase 8 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 748
- Clinical molecules 280
- Avg pChEMBL 6.99
KEGG Pathways (75)
- AGE-RAGE signaling pathway in diabetic complications
- Adipocytokine signaling pathway
- Alcoholic liver disease
- Alzheimer disease
- Apoptosis
- Apoptosis - multiple species
- Autophagy - animal
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Choline metabolism in cancer
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Endocrine resistance
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- ErbB signaling pathway
- Fc epsilon RI signaling pathway
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Human T-cell leukemia virus 1 infection
- Human immunodeficiency virus 1 infection
- Huntington disease
- IL-17 signaling pathway
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- Mitophagy - animal
- NOD-like receptor signaling pathway
- Necroptosis
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- Osteoclast differentiation
- Pancreatic cancer
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Protein processing in endoplasmic reticulum
- RIG-I-like receptor signaling pathway
- Ras signaling pathway
- Relaxin signaling pathway
- Retrograde endocannabinoid signaling
- Salmonella infection
- Shigellosis
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Tight junction
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- Wnt signaling pathway
- Yersinia infection
- cAMP signaling pathway
Active Molecules (748)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SOIQVEVFDNZKNF
|
6.7 | IC50 | 3 | — | |
WYBGYJNIKOAPQI
|
6.7 | Ki | 4 | — | |
XBAIEEJJCJHBDL
|
6.7 | Ki | 17 | — | |
YGGYBJSDWZSAAU
|
6.7 | IC50 | 5 | — | |
HZTYDQRUAWIZRE
|
6.7 | Kd | 40 | Yes | |
JIVYDIADMNEKCM
|
6.7 | IC50 | 2 | — | |
MIFPZJRPCSILQA
|
6.7 | IC50 | 3 | — | |
OGNOHOPSWWOASA
|
6.7 | Kd | 3 | — | |
SHBXAJXKKQHYFU
|
6.7 | IC50 | 2 | Yes | |
JOWZBTCWJHFAQE
|
6.7 | IC50 | 4 | — | |
CCZSCWIBOWLLIO
|
6.7 | IC50 | 2 | Yes | |
HKSZLNNOFSGOKW
|
6.7 | Kd | 213 | — | |
HPQZTEVMVAVGJO
|
6.7 | Kd | 5 | — | |
KSZHRLGDJPCAID
|
6.7 | IC50 | 2 | Yes | |
LRMJMUNRVWCGNU
|
6.7 | IC50 | 2 | Yes | |
ORAWIJDEGBHDCO
|
6.6 | IC50 | 4 | Yes | |
SPOFWIHFQUTCOI
|
6.6 | IC50 | 2 | Yes | |
WMTFXHFSJAESMU
|
6.6 | IC50 | 3 | Yes | |
XDEFNAWAKYQBQY
|
6.6 | IC50 | 3 | — | |
DZCSIYOZJRMQKN
|
6.6 | IC50 | 2 | Yes | |
FVONQZQMUHLATI
|
6.6 | IC50 | 2 | — | |
NRJKIOCCERLIDG
|
6.6 | Kd | 6 | — | |
SZHHSFHOIDCNLD
|
6.6 | Kd | 6 | — | |
SZHHSFHOIDCNLD
|
6.6 | Kd | 3 | — | |
WBSWWONMTZEOGS
|
6.6 | Kd | 5 | — | |
XURAVYGNAAUXQP
|
6.6 | Kd | 3 | — | |
HVLBTSWQHJSANX
|
6.6 | IC50 | 3 | Yes | |
FUMCKNCUEAQHCV
|
6.6 | Ki | 103 | — | |
GQLWKGVBOIYMTN
|
6.6 | Ki | 35 | — | |
JIZAXYFIPHHWDF
|
6.6 | IC50 | 2 | Yes | |
LRINYHMQZRENCY
|
6.6 | Ki | 29 | — | |
NIWQPPGSGWOACD
|
6.6 | IC50 | 2 | — | |
NMHMCXTYPRADBA
|
6.6 | Ki | 20 | — | |
PSLDQEIGOZTJMS
|
6.6 | IC50 | 3 | — | |
VEKQRWMLMKCRSW
|
6.6 | IC50 | 3 | Yes | |
XKZQZMSAWVDRSP
|
6.6 | Ki | 39 | Yes | |
YYZKQTUYOUJSCB
|
6.6 | IC50 | 2 | — | |
QJBMKTXSJOENPI
|
6.6 | IC50 | 4 | — | |
VPSYCQPUUYBBBQ
|
6.6 | IC50 | 2 | — | |
DPYBBGZWQJVQMB
|
6.6 | IC50 | 2 | Yes | |
JOOXLOJCABQBSG
|
6.6 | Kd | 139 | — | |
OTFWOWGRYVMGKI
|
6.6 | IC50 | 3 | — | |
QCQCMNUQTMIKHU
|
6.6 | IC50 | 2 | Yes | |
RTMJIFPHPQZXEZ
|
6.6 | IC50 | 2 | Yes | |
YFZJFPUOKUFWQU
|
6.6 | IC50 | 4 | — | |
JDCPDRSOEKCKGX
|
6.6 | IC50 | 2 | Yes | |
MGGUVSLBKUKUGR
|
6.6 | IC50 | 3 | Yes | |
MKUCYQPSROSPGD
|
6.6 | IC50 | 4 | Yes | |
NDFIMKGGYOQCBV
|
6.6 | IC50 | 2 | Yes | |
RSBSYGXBCWDUEI
|
6.6 | IC50 | 2 | Yes |