Target Details
| UniProt AC | P42574 |
|---|---|
| Gene Symbol | CASP3 |
| Protein Name | Caspase-3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00656 (Peptidase_C14) |
Summary
- Multi-target molecules 444
- Clinical molecules 0
- Avg pChEMBL 7.52
KEGG Pathways (46)
- AGE-RAGE signaling pathway in diabetic complications
- Alcoholic liver disease
- Alzheimer disease
- Amoebiasis
- Amyotrophic lateral sclerosis
- Apoptosis
- Apoptosis - multiple species
- Colorectal cancer
- Cytosolic DNA-sensing pathway
- Efferocytosis
- Epithelial cell signaling in Helicobacter pylori infection
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Huntington disease
- IL-17 signaling pathway
- Influenza A
- Kaposi sarcoma-associated herpesvirus infection
- Legionellosis
- Lipid and atherosclerosis
- MAPK signaling pathway
- Measles
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Non-alcoholic fatty liver disease
- Parkinson disease
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Platinum drug resistance
- Prion disease
- Proteoglycans in cancer
- Salmonella infection
- Serotonergic synapse
- Small cell lung cancer
- TNF signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
- Viral myocarditis
- p53 signaling pathway
Active Molecules (444)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
YIJAKKNPGYYTDG
|
7.8 | IC50 | 2 | — | |
YLSHULIHKQRKEM
|
7.8 | IC50 | 4 | — | |
LPQLYZKOKVZVSN
|
7.8 | IC50 | 4 | — | |
LPQLYZKOKVZVSN
|
7.8 | IC50 | 4 | — | |
MEOSEAYZHVITJF
|
7.8 | IC50 | 3 | — | |
MEOSEAYZHVITJF
|
7.8 | IC50 | 3 | — | |
VADGDBPFZAUONM
|
7.8 | IC50 | 5 | — | |
WCKOPJZBWUAFCU
|
7.8 | IC50 | 3 | — | |
XRLQEVLRBDPXIT
|
7.8 | IC50 | 2 | — | |
MFWZBTUZXAYVJI
|
7.8 | IC50 | 2 | — | |
CBWLTWDVCXFXAG
|
7.8 | IC50 | 2 | — | |
CLVRDSQHWNEIQR
|
7.8 | IC50 | 2 | — | |
VGTVMULINBNZTO
|
7.7 | IC50 | 2 | — | |
YZLOAXMFYBNUPB
|
7.7 | IC50 | 2 | — | |
YZZZZAGTJYSDAA
|
7.7 | IC50 | 2 | — | |
AYNCKCVIBWBSLQ
|
7.7 | IC50 | 2 | — | |
ODDLUJFKRBXEAV
|
7.7 | IC50 | 2 | — | |
ULCFZQSGHFDDRB
|
7.7 | Ki | 3 | — | |
NAJZBQCCBCKDIT
|
7.7 | Ki | 3 | — | |
SXHHMPCBHMVLQW
|
7.7 | IC50 | 3 | — | |
XFDDCMWVWGKTPZ
|
7.7 | IC50 | 2 | — | |
ZOVHWLRITDMPBF
|
7.7 | Ki | 3 | — | |
QKPDRLZDNXVLDS
|
7.7 | IC50 | 2 | — | |
CLKQXEGDLZQTME
|
7.7 | IC50 | 4 | — | |
FAUAEUUDLKHDDN
|
7.7 | Ki | 3 | — | |
PFAYCUAUBOGVDX
|
7.7 | IC50 | 2 | — | |
YDTJDBMJRVDMKU
|
7.7 | IC50 | 2 | — | |
IXHDMUUZYOETNX
|
7.7 | IC50 | 2 | — | |
UYLOQGSFWYOIGW
|
7.7 | Ki | 3 | — | |
APKUVGMUIXJJAR
|
7.6 | IC50 | 2 | — | |
HERMWEDKDQDOTD
|
7.6 | IC50 | 2 | — | |
YDWMZYBWKLFQKO
|
7.6 | IC50 | 3 | — | |
HLQVEUCDTUXVLS
|
7.6 | IC50 | 2 | — | |
MVYQTZKRBIBPEP
|
7.6 | Ki | 3 | — | |
ANNPALXBOKTDBF
|
7.6 | IC50 | 4 | — | |
NJXLWRJQLADOSG
|
7.6 | IC50 | 2 | — | |
NORINPJAWOULPP
|
7.6 | IC50 | 2 | — | |
OZAFISSWLZQMIS
|
7.6 | IC50 | 5 | — | |
SJKUPJSYABBYEV
|
7.6 | IC50 | 2 | — | |
ZYUWEIWFRAQKJA
|
7.6 | Ki | 3 | — | |
APKUVGMUIXJJAR
|
7.6 | IC50 | 2 | — | |
LRIRHRYRLCJRQA
|
7.6 | IC50 | 2 | — | |
DFTYYYJXYFUPCV
|
7.6 | IC50 | 2 | — | |
KDLXHHHHLWQUJW
|
7.6 | Ki | 3 | — | |
UCXMBOHIKJZNMQ
|
7.6 | Ki | 2 | — | |
RHNPIGHUWVOJIW
|
7.6 | IC50 | 2 | — | |
BKPXQFIGDXODGX
|
7.5 | IC50 | 2 | — | |
IYQGSYZQNLKUSS
|
7.5 | Ki | 3 | — | |
VIUJQQJJJZNKDP
|
7.5 | IC50 | 4 | — | |
BRCVHXRLGOWCTD
|
7.5 | IC50 | 2 | — |