Target Details
| UniProt AC | P42338 |
|---|---|
| Gene Symbol | PIK3CB |
| Protein Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00454 (PI3_PI4_kinase) PF00792 (PI3K_C2) PF02192 (PI3K_p85B) PF00794 (PI3K_rbd) PF00613 (PI3Ka) |
Summary
- Multi-target molecules 1,951
- Clinical molecules 55
- Avg pChEMBL 7.07
KEGG Pathways (109)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Inositol phosphate metabolism
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- Metabolic pathways
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Active Molecules (1,951)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VCYZTIOXWVBBMW
|
8.2 | IC50 | 4 | — | |
OKZVXALNOKYCRL
|
8.2 | Kd | 5 | — | |
VHMBIMDLAGQBLT
|
8.2 | IC50 | 4 | — | |
CFKIDVSIVXEAHH
|
8.2 | IC50 | 4 | — | |
OVRXDSQQCRJQMD
|
8.2 | IC50 | 4 | — | |
DCBRPTMPTRRLGM
|
8.2 | IC50 | 5 | — | |
DWZAEMINVBZMHQ
|
8.2 | IC50 | 6 | — | |
FYGDHTMAQTVJIR
|
8.2 | IC50 | 8 | — | |
HULWHZOGNQAZMZ
|
8.2 | IC50 | 3 | — | |
JBCFMJUKWOMHEO
|
8.2 | IC50 | 6 | — | |
KLYFMVNJPUCDKG
|
8.2 | IC50 | 4 | — | |
KRSNHRXVUCZIHY
|
8.2 | Ki | 4 | — | |
KUGIFHQBIIHRIZ
|
8.2 | Ki | 5 | — | |
MUSGURQXGKSPBK
|
8.2 | IC50 | 3 | — | |
NELIWFYNFRAAFX
|
8.2 | IC50 | 3 | — | |
OPPWXPBWFXJSQN
|
8.2 | IC50 | 2 | — | |
RPNYSADTAYSTDL
|
8.2 | IC50 | 4 | — | |
SYUHGFRIKWMPPV
|
8.2 | Ki | 5 | — | |
VYOJFSXRCPAYQT
|
8.2 | IC50 | 3 | — | |
GVCOXBXPKBZDEG
|
8.2 | IC50 | 4 | — | |
XAZDYPNMXGDMSA
|
8.2 | IC50 | 5 | — | |
YTWYXKYMMKOBOM
|
8.2 | IC50 | 2 | — | |
DAVVAILUXDUQOI
|
8.2 | Ki | 4 | — | |
PKOQQRKDYMICGM
|
8.2 | IC50 | 3 | — | |
VWTYNLODLZUBHL
|
8.2 | IC50 | 3 | — | |
XRRVKXNLNMOJHB
|
8.2 | IC50 | 2 | — | |
ZSSRTWRLQWTKMG
|
8.2 | IC50 | 4 | — | |
BHDAOCAOTBBVOL
|
8.2 | IC50 | 4 | — | |
IKOMEEOWOYEDAK
|
8.2 | IC50 | 3 | — | |
JERUPDZCEQJOGZ
|
8.2 | IC50 | 4 | — | |
YEOFKDOQMIILQR
|
8.2 | IC50 | 4 | — | |
JMCCNBLPWHIWCV
|
8.2 | IC50 | 4 | — | |
FZBMKSZVGOJNQF
|
8.2 | IC50 | 2 | — | |
ADLJEZREHNJMCU
|
8.2 | IC50 | 6 | — | |
AMPOIPUWOSOMBW
|
8.2 | IC50 | 4 | — | |
BAQGYVIJTGMSNW
|
8.2 | IC50 | 5 | — | |
BJNCOVPPPKXBBA
|
8.2 | IC50 | 8 | — | |
BPFCAIMDJPJDIW
|
8.2 | IC50 | 3 | — | |
DFIFOYFVGAPUQY
|
8.2 | Ki | 2 | — | |
FMHBWTDRUBUIMR
|
8.2 | IC50 | 2 | — | |
HCGYTLSSUHSQGE
|
8.2 | IC50 | 5 | — | |
HJMSDMFCCDZFIX
|
8.2 | Ki | 4 | — | |
HTLPVYXAOHAAIF
|
8.2 | IC50 | 3 | — | |
IKMGXHANXSBCRK
|
8.2 | IC50 | 4 | — | |
KTMLCPCWNLTDRL
|
8.2 | IC50 | 3 | — | |
NAHLQGSZCFKYIR
|
8.2 | IC50 | 4 | — | |
NRFWIMBKAYHJFY
|
8.2 | Ki | 4 | — | |
OIPZJHZMJMKKBK
|
8.2 | Ki | 4 | — | |
QCSBWICWLKTERT
|
8.2 | IC50 | 5 | — | |
UHDLRSYRMVRGIY
|
8.2 | IC50 | 3 | — |