Target Details
| UniProt AC | P42336 |
|---|---|
| Gene Symbol | PIK3CA |
| Protein Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00454 (PI3_PI4_kinase) PF00792 (PI3K_C2) PF02192 (PI3K_p85B) PF00794 (PI3K_rbd) PF00613 (PI3Ka) |
Summary
- Multi-target molecules 5,616
- Clinical molecules 115
- Avg pChEMBL 7.53
KEGG Pathways (109)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Amoebiasis
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bacterial invasion of epithelial cells
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Coronavirus disease - COVID-19
- Diabetic cardiomyopathy
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Inflammatory mediator regulation of TRP channels
- Influenza A
- Inositol phosphate metabolism
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leukocyte transendothelial migration
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- Measles
- Melanoma
- Metabolic pathways
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phosphatidylinositol signaling system
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Type II diabetes mellitus
- VEGF signaling pathway
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- mTOR signaling pathway
Associated Diseases (15)
- Breast cancer
- CLAPO syndrome
- Cerebral cavernous malformation
- Colorectal cancer
- Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
- Cowden syndrome
- Desmoplastic small round cell tumor
- Epidermal nevus
- Gastric cancer
- Hepatocellular carcinoma
- Macrodactyly
- Megalencephaly-capillary malformation syndrome
- Non-small cell lung cancer
- Ovarian cancer
- Seborrheic keratosis
Active Molecules (5,616)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KOBDMZOFSXEFLG
|
8.9 | IC50 | 2 | — | |
LCMMFSOTAUQSFR
|
8.9 | IC50 | 2 | — | |
LEDZNERMENQHCL
|
8.9 | Ki | 2 | — | |
MGQDDAHTGNTYQE
|
8.9 | IC50 | 3 | — | |
MKGZBKFXWSPUTF
|
8.9 | Ki | 3 | Yes | |
MLVGNMUJLBIZJL
|
8.9 | IC50 | 2 | — | |
PSMZPNCNFATMGI
|
8.9 | IC50 | 3 | — | |
RGXYXEURNXNTPI
|
8.9 | IC50 | 2 | — | |
RXZWDJAMFHLGND
|
8.9 | IC50 | 5 | — | |
UMKRKGXFZCMRBW
|
8.9 | IC50 | 2 | — | |
WLSPNBWMOAQJOV
|
8.9 | IC50 | 3 | — | |
XNIJHVMYDIVRJQ
|
8.9 | Ki | 3 | Yes | |
YGBMCLDVRUGXOV
|
8.9 | Ki | 8 | Yes | |
JYBBRWIADLMZMN
|
8.9 | IC50 | 2 | — | |
FQCMZVNUJBMMGN
|
8.9 | Ki | 2 | — | |
KFRYLKUWPBCQSK
|
8.9 | Ki | 2 | — | |
WSUHUOXZUDRIIG
|
8.9 | Ki | 2 | — | |
YMEOFCCPGXRNDQ
|
8.9 | Ki | 2 | — | |
AXPPNBSZEZBBTI
|
8.9 | IC50 | 2 | — | |
CLUPBYKXRIWQCL
|
8.9 | IC50 | 2 | — | |
DSQMZMYODKOODL
|
8.9 | IC50 | 3 | — | |
DVUUYTUKCBSKDI
|
8.9 | IC50 | 2 | — | |
FXNPXFSTJWGUJP
|
8.9 | Ki | 2 | — | |
GTYLCXYLEISNGQ
|
8.9 | IC50 | 2 | — | |
GZWUFUZDDITKGF
|
8.9 | IC50 | 6 | — | |
IWVNGHIFTPGMQQ
|
8.9 | IC50 | 2 | — | |
JCXHJZJTKTWCDL
|
8.9 | IC50 | 4 | — | |
KPHKHHHLIKEDLQ
|
8.9 | IC50 | 5 | — | |
OCUSQBHBVRHUQH
|
8.9 | Ki | 2 | — | |
OTDHPYIOOXCZJI
|
8.9 | IC50 | 3 | — | |
PVRCMSRKSNSFMD
|
8.9 | IC50 | 2 | — | |
QCCOLUPBMNMYNZ
|
8.9 | Ki | 2 | — | |
UTJPCLXVDNMKDZ
|
8.9 | IC50 | 2 | — | |
UWTJOXOCUBXFIJ
|
8.9 | IC50 | 2 | — | |
VAWUMMRNRUYZAS
|
8.9 | IC50 | 5 | — | |
WPGMPVQQAQXPTL
|
8.9 | IC50 | 2 | — | |
GWNBFGJNUNUOOI
|
8.9 | IC50 | 17 | — | |
JSHYXEIUPKHNJL
|
8.9 | Ki | 2 | — | |
XLJIDGVINVIZPC
|
8.9 | IC50 | 3 | — | |
RTUHEKLMDKJAQG
|
8.9 | Ki | 2 | — | |
YOPZKHFULRIPPD
|
8.9 | Ki | 2 | — | |
ZCIKTYHGDNOCCK
|
8.9 | IC50 | 2 | — | |
GNXZUOBKPLODBE
|
8.9 | Ki | 2 | — | |
PMPBNZKNCMHNLB
|
8.9 | Ki | 2 | — | |
QKUMTMOJNZWMQU
|
8.9 | IC50 | 4 | — | |
XEEIADSVQRAGOH
|
8.9 | Ki | 2 | — | |
XXCNRIQOMCLWNK
|
8.9 | Ki | 2 | — | |
ABOUWUWXUJHANF
|
8.8 | IC50 | 2 | — | |
BLOUAHHDWSECSU
|
8.8 | IC50 | 3 | — | |
DVLVYFPEVHXTKT
|
8.8 | IC50 | 2 | — |