Target Details
| UniProt AC | P42224 |
|---|---|
| Gene Symbol | STAT1 |
| Protein Name | Signal transducer and activator of transcription 1-alpha/beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00017 (SH2) PF12162 (STAT1_TAZ2bind) PF01017 (STAT_alpha) PF02864 (STAT_bind) PF02865 (STAT_int) PF21354 (STAT_linker) |
Summary
- Multi-target molecules 4
- Clinical molecules 0
- Avg pChEMBL 6.42
KEGG Pathways (29)
- AGE-RAGE signaling pathway in diabetic complications
- C-type lectin receptor signaling pathway
- Chemokine signaling pathway
- Coronavirus disease - COVID-19
- Epstein-Barr virus infection
- Growth hormone synthesis, secretion and action
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human papillomavirus infection
- Inflammatory bowel disease
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pancreatic cancer
- Pathways in cancer
- Prolactin signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
Associated Diseases (2)
Active Molecules (4)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RZNVRPFTVXTCDL
|
6.7 | IC50 | 3 | — | |
NNSKHOBWYYGACP
|
6.5 | IC50 | 2 | — | |
YDLNHZCBARMOQT
|
6.5 | IC50 | 2 | — | |
JKCSCHXVWPSGBG
|
6.0 | Kd | 3 | — |