IARS1 — MultiTargetDB

Target Details

UniProt AC	`P41252`
Gene Symbol	IARS1
Protein Name	Isoleucine--tRNA ligase, cytoplasmic
Organism	Homo sapiens
Entry Name
Organism Category	Human
Pfam Domains	PF08264 (Anticodon_1) PF19302 (DUF5915) PF00133 (tRNA-synt_1) PF23567 (Ubiquitin_IARS1)

Summary

Multi-target molecules 12
Clinical molecules 0
Avg pChEMBL 7.24

KEGG Pathways (1)

Aminoacyl-tRNA biosynthesis

Associated Diseases (1)

Growth retardation, impaired intellectual development, hypotonia, and hepatopathy

Top Co-occurrence Targets

ileS 8 shared
ileS 2 shared
CEPT1 1 shared
DYNC1LI1 1 shared
BZW2 1 shared
MTCH2 1 shared
CLIC4 1 shared
COPG1 1 shared
IRAK3 1 shared
SNX9 1 shared

Active Molecules (12)

InChIKey	pChEMBL	Type	Targets	Clinical
`MINDHVHHQZYEEK`	9.1	IC50	2	—
`SKMGGGPZQRRMTG`	7.6	IC50	2	—
`QMWNPOPSMQKQAL`	7.5	IC50	2	—
`XSRXZXOKBZFCHB`	7.3	IC50	2	—
`WCVCPXUETPTILF`	7.0	IC50	2	—
`ZCCPLJOKGAACRT`	7.0	Kd	599	—
`ADKZHDGLJXVNIT`	7.0	IC50	2	—
`WAXQESJXPPKIIV`	7.0	IC50	2	—
`ORNSGNNIYULCMK`	6.9	IC50	2	—
`VMXXHKARGFATOU`	6.9	IC50	2	—
`WNORCWSRNMBRBU`	6.8	IC50	2	—
`BIRNJUNFRITRFT`	6.7	IC50	2	—