Target Details
| UniProt AC | P40763 |
|---|---|
| Gene Symbol | STAT3 |
| Protein Name | Signal transducer and activator of transcription 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00017 (SH2) PF01017 (STAT_alpha) PF02864 (STAT_bind) PF02865 (STAT_int) PF21354 (STAT_linker) |
Summary
- Multi-target molecules 49
- Clinical molecules 1
- Avg pChEMBL 7.03
KEGG Pathways (33)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- FoxO signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hormone signaling
- Human cytomegalovirus infection
- Inflammatory bowel disease
- Insulin resistance
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Measles
- MicroRNAs in cancer
- Necroptosis
- Non-small cell lung cancer
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- Pancreatic cancer
- Pathways in cancer
- Prolactin signaling pathway
- Proteoglycans in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th17 cell differentiation
- Toxoplasmosis
- Viral carcinogenesis
Associated Diseases (4)
Active Molecules (49)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
MKCRMYBGJIPMII
|
8.2 | IC50 | 2 | — | |
OWVQDCLKFMZDNW
|
8.2 | IC50 | 2 | — | |
YKGAFKZFWIEKPK
|
8.1 | IC50 | 2 | — | |
UIARLYUEJFELEN
|
8.0 | IC50 | 289 | Yes | |
BXKBUWYXXKDGHW
|
7.9 | IC50 | 6 | — | |
IIRJKMJZLJRGQN
|
7.9 | IC50 | 3 | — | |
NAQXRHXESYEFJR
|
7.8 | IC50 | 3 | — | |
FEQOESZUGZISHK
|
7.8 | IC50 | 9 | — | |
SBJKITGOXSWAGF
|
7.5 | IC50 | 4 | — | |
XFGPGTRHNMKJSB
|
7.5 | IC50 | 2 | — | |
XUZMWHLSFXCVMG
|
7.5 | IC50 | 24 | — | |
BKAQLWBLTMZOOO
|
7.5 | Kd | 12 | — | |
UGPDJSYAEGUOSO
|
7.4 | IC50 | 6 | — | |
LOWWYYZBZNSPDT
|
7.4 | IC50 | 5 | — | |
PDOQBOJDRPLBQU
|
7.4 | IC50 | 21 | — | |
JKCSCHXVWPSGBG
|
7.4 | Kd | 3 | — | |
NNSKHOBWYYGACP
|
7.2 | IC50 | 2 | — | |
CYGJLKBTKVKZQE
|
7.2 | IC50 | 6 | — | |
GOMZFYXJYBWQHL
|
7.2 | IC50 | 2 | — | |
QLPWFQPHRAFDGC
|
7.2 | IC50 | 7 | — | |
IYCVFSSCAPZAJP
|
7.1 | IC50 | 5 | — | |
AYYRUOOCJNTWHJ
|
7.1 | IC50 | 5 | — | |
BZZKEPGENYLQSC
|
7.0 | IC50 | 6 | — | |
YDLNHZCBARMOQT
|
7.0 | IC50 | 2 | — | |
LHEVQARANJPCFT
|
7.0 | IC50 | 9 | — | |
JRUFBZGMCKTNQR
|
6.9 | IC50 | 5 | — | |
NFYDBBVZKANMEX
|
6.9 | IC50 | 4 | — | |
RILOFFQNUDZMEB
|
6.9 | IC50 | 3 | — | |
HZNQENBILSFKNN
|
6.9 | IC50 | 5 | — | |
IYCVFSSCAPZAJP
|
6.8 | IC50 | 4 | — | |
VGBYAYCYPVFDTM
|
6.8 | IC50 | 6 | — | |
OPRMTHPWLRWOPL
|
6.7 | IC50 | 3 | — | |
BZCRXIUFMBZXPZ
|
6.7 | IC50 | 16 | — | |
RJMUSRYZPJIFPJ
|
6.6 | IC50 | 3 | — | |
SYYQNYIBIFOCPS
|
6.6 | IC50 | 5 | — | |
VYUZMRQDNWEZOD
|
6.6 | IC50 | 5 | — | |
FJLUYTVEVSZLJP
|
6.6 | IC50 | 5 | — | |
VHTVGRLZQWFMBU
|
6.6 | IC50 | 5 | — | |
ZGBAGWYVESAQAG
|
6.6 | IC50 | 6 | — | |
AMYVQFXKGYPZLQ
|
6.5 | Kd | 2 | — | |
VFPYGNNOSJWBHF
|
6.5 | Kd | 2 | — | |
YHBWHSCISDHNCC
|
6.5 | IC50 | 4 | — | |
LMPLILRWPQMYES
|
6.3 | IC50 | 5 | — | |
TXELAYINOQAWIB
|
6.2 | IC50 | 5 | — | |
ZRRGOUHITGRLBA
|
6.2 | IC50 | 2 | — | |
WDJUZGPOPHTGOT
|
6.2 | IC50 | 11 | — | |
PIAOPVOJTUSVEB
|
6.1 | IC50 | 3 | — | |
MWKSRKSEWLRPBL
|
6.0 | Kd | 1075 | — | |
GJMZWYLOARVASY
|
6.0 | IC50 | 6 | — |