Target Details
| UniProt AC | P36897 |
|---|---|
| Gene Symbol | TGFBR1 |
| Protein Name | TGF-beta receptor type-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF01064 (Activin_recp) PF00069 (Pkinase) PF08515 (TGF_beta_GS) |
Summary
- Multi-target molecules 428
- Clinical molecules 14
- Avg pChEMBL 7.75
KEGG Pathways (23)
- AGE-RAGE signaling pathway in diabetic complications
- Adherens junction
- Apelin signaling pathway
- Cellular senescence
- Chagas disease
- Chronic myeloid leukemia
- Colorectal cancer
- Cytokine-cytokine receptor interaction
- Diabetic cardiomyopathy
- Endocytosis
- FoxO signaling pathway
- Gastric cancer
- Hepatitis B
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human T-cell leukemia virus 1 infection
- MAPK signaling pathway
- Osteoclast differentiation
- Pancreatic cancer
- Pathways in cancer
- Relaxin signaling pathway
- TGF-beta signaling pathway
- Th17 cell differentiation
Associated Diseases (3)
Active Molecules (428)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QQWUGDVOUVUTOY
|
6.7 | Kd | 231 | Yes | |
CSZAJEXPQFERTK
|
6.7 | IC50 | 10 | — | |
OUKYUETWWIPKQR
|
6.7 | Kd | 31 | Yes | |
UNBNKYSPLOMIOY
|
6.7 | IC50 | 7 | — | |
WKDACQVEJIVHMZ
|
6.7 | Kd | 46 | — | |
KUWVOCJVMUNDRT
|
6.7 | IC50 | 2 | — | |
OOMBFNDWQIGHEK
|
6.7 | Kd | 22 | — | |
CXZJXVJPISUKMR
|
6.7 | IC50 | 6 | — | |
UZNTWHBHIHKRLK
|
6.7 | IC50 | 2 | — | |
ZPKLGSLFCKFOCY
|
6.7 | IC50 | 3 | — | |
ALKJNCZNEOTEMP
|
6.6 | Kd | 55 | — | |
PMAOQJFALVYUQZ
|
6.6 | IC50 | 2 | — | |
YDKNADAGXQBUTQ
|
6.6 | IC50 | 2 | — | |
ZBNZXTGUTAYRHI
|
6.6 | Kd | 102 | Yes | |
HGJGLMBKNFJBHW
|
6.6 | IC50 | 2 | — | |
WFZZPLAPENBNIY
|
6.6 | IC50 | 3 | — | |
BYKVUESQXQHBEP
|
6.6 | IC50 | 7 | — | |
NIOZQSIYXGTSOO
|
6.6 | IC50 | 2 | — | |
HIKFXURRIPQGSA
|
6.6 | IC50 | 2 | — | |
UPBPVAZUFAXUAC
|
6.6 | IC50 | 6 | — | |
CJLMANFTWLNAKC
|
6.5 | IC50 | 5 | — | |
BARYYLFEOIUPEY
|
6.5 | IC50 | 4 | Yes | |
UQEFQNWFVJXGDE
|
6.5 | IC50 | 3 | — | |
PAHLIVNOHVHPBG
|
6.5 | IC50 | 6 | — | |
PDZAPYOZOLWESW
|
6.5 | IC50 | 4 | — | |
VTGUKXAQUOKKSW
|
6.5 | IC50 | 3 | — | |
QFFKJPJEWNRMHC
|
6.5 | IC50 | 2 | — | |
YRRRHSNOXWKVDL
|
6.5 | Kd | 5 | — | |
SHWKNOUREYUNBF
|
6.5 | IC50 | 6 | — | |
ZBOSAPQCJDMZCV
|
6.5 | IC50 | 6 | — | |
JQLXLCYSWMVCLC
|
6.5 | IC50 | 2 | — | |
MMQQLUARMBFVKE
|
6.5 | IC50 | 2 | — | |
IPYHSGOSLLXUJY
|
6.5 | IC50 | 2 | — | |
OUGRNXPVTYJQNC
|
6.4 | IC50 | 2 | — | |
QMPQJWQHTDPWNU
|
6.4 | IC50 | 2 | — | |
XZPCSXAQYZGHKR
|
6.4 | IC50 | 2 | — | |
ZNEAEMOGRAJFJZ
|
6.4 | IC50 | 2 | — | |
FUWKNYZEQAGYBA
|
6.4 | IC50 | 3 | Yes | |
LDKHTALMQVJDPD
|
6.4 | IC50 | 4 | Yes | |
LPNSUJMINOXWJC
|
6.4 | IC50 | 6 | — | |
CDOVNWNANFFLFJ
|
6.3 | IC50 | 10 | — | |
MXJMJNRCJKHFPP
|
6.3 | IC50 | 10 | — | |
OVAAGWFAUDJCKW
|
6.3 | IC50 | 2 | — | |
DPDZHVCKYBCJHW
|
6.3 | IC50 | 11 | — | |
HABRRQSUPGOZTD
|
6.3 | IC50 | 3 | Yes | |
RIXHCYHQTKRWDU
|
6.3 | IC50 | 4 | Yes | |
WELLLPRMKHYPPA
|
6.3 | IC50 | 2 | — | |
UARVSLPFGRKWQN
|
6.3 | IC50 | 11 | — | |
PVDWNOWJXDXMDH
|
6.2 | IC50 | 5 | — | |
WLXBZZLKNLKRKJ
|
6.2 | IC50 | 3 | — |