Target Details
| UniProt AC | P36873 |
|---|---|
| Gene Symbol | PPP1CC |
| Protein Name | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00149 (Metallophos) PF16891 (STPPase_N) |
Summary
- Multi-target molecules 5
- Clinical molecules 0
- Avg pChEMBL 8.14
KEGG Pathways (23)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Amphetamine addiction
- Cadherin signaling
- Cellular senescence
- Diabetic cardiomyopathy
- Dopaminergic synapse
- Focal adhesion
- Herpes simplex virus 1 infection
- Hippo signaling pathway
- Inflammatory mediator regulation of TRP channels
- Insulin resistance
- Insulin signaling pathway
- Long-term potentiation
- Oocyte meiosis
- Oxytocin signaling pathway
- Platelet activation
- Proteoglycans in cancer
- Regulation of actin cytoskeleton
- Vascular smooth muscle contraction
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mRNA surveillance pathway
Active Molecules (5)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FKAWLXNLHHIHLA
|
9.0 | IC50 | 6 | — | |
ZYZCGGRZINLQBL
|
8.9 | IC50 | 8 | — | |
VAIBGAONSFVVKI
|
8.8 | IC50 | 2 | — | |
QNDVLZJODHBUFM
|
7.3 | IC50 | 7 | — | |
KZQWOEXRMPURDP
|
6.7 | IC50 | 6 | — |