Target Details
| UniProt AC | P36507 |
|---|---|
| Gene Symbol | MAP2K2 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 146
- Clinical molecules 16
- Avg pChEMBL 7.02
KEGG Pathways (80)
- Acute myeloid leukemia
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (3)
Active Molecules (146)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
RSECRMOYVYYDGW
|
7.3 | IC50 | 2 | — | |
WINHZLLDWRZWRT
|
7.3 | Ki | 66 | — | |
KDQMGKLTDPLARQ
|
7.3 | IC50 | 2 | — | |
DUKJABPGWUISRC
|
7.2 | IC50 | 10 | — | |
GLTAPZSWBNABCW
|
7.2 | IC50 | 2 | — | |
ZCHZSBUNJOCWCW
|
7.2 | IC50 | 3 | — | |
OWRXHGAFWZFFCW
|
7.2 | Ki | 113 | — | |
UQNNJYLAPYGZBD
|
7.2 | Ki | 28 | — | |
DWSUEVLMRQIQIK
|
7.1 | IC50 | 2 | — | |
IBQHEUNEKDNNRF
|
7.1 | IC50 | 2 | — | |
LMMJFBMMJUMSJS
|
7.1 | IC50 | 5 | — | |
FENWEVRRFMFDBS
|
7.1 | IC50 | 2 | — | |
GFXDMBPHZFCKLA
|
7.1 | IC50 | 2 | — | |
UEJXELMBDCXXAQ
|
7.1 | IC50 | 9 | — | |
KPZWCJJIVRSDTG
|
7.0 | IC50 | 2 | — | |
LRYALXABQZRRNT
|
7.0 | IC50 | 2 | — | |
SUDAHWBOROXANE
|
7.0 | IC50 | 6 | — | |
VCFDMLBPASGZTP
|
7.0 | Ki | 38 | — | |
REMYZOSCCVDLDL
|
7.0 | IC50 | 2 | — | |
SSHPKJMEPSZLTL
|
7.0 | IC50 | 2 | — | |
WINHZLLDWRZWRT
|
7.0 | Kd | 201 | Yes | |
YVSXASJEPXDDQH
|
7.0 | IC50 | 2 | — | |
CTNPALGJUAXMMC
|
6.9 | Kd | 151 | — | |
NIZMUWJLIMKOIH
|
6.9 | IC50 | 2 | — | |
RGNHKJWHFIPHIM
|
6.9 | Ki | 66 | — | |
WPHKIQPVPYJNAX
|
6.9 | Ki | 81 | — | |
NFKACFNEFTYTHG
|
6.9 | IC50 | 2 | — | |
GFMMXOIFOQCCGU
|
6.9 | IC50 | 4 | — | |
IFPPYSWJNWHOLQ
|
6.8 | Ki | 52 | Yes | |
ROZUZKLWYFJFQI
|
6.8 | IC50 | 2 | — | |
QPIFMCLNACVAAT
|
6.7 | IC50 | 7 | — | |
PFHWTBSZWRJPNA
|
6.7 | IC50 | 2 | — | |
GHWGOWZXFSETFX
|
6.7 | IC50 | 2 | — | |
AEYLJTAIDDIOBA
|
6.7 | Ki | 53 | — | |
DVEXZJFMOKTQEZ
|
6.7 | IC50 | 4 | — | |
JSAQBOQCZJHWMA
|
6.7 | Kd | 11 | — | |
OGNYUTNQZVRGMN
|
6.7 | Ki | 16 | Yes | |
SVEVUVOIIOZGQC
|
6.7 | IC50 | 2 | — | |
FORDRPJSYCKZQK
|
6.7 | IC50 | 2 | — | |
MFAQYJIYDMLAIM
|
6.7 | Kd | 130 | Yes | |
ULGFNGZSEVQFRS
|
6.7 | IC50 | 2 | — | |
UVNRELDVCTVFNZ
|
6.6 | IC50 | 2 | — | |
HALXYXINRHRFCA
|
6.6 | IC50 | 2 | — | |
RYYNGWLOYLRZLK
|
6.6 | Ki | 104 | — | |
VNDWQCSOSCCWIP
|
6.6 | IC50 | 39 | Yes | |
QXINTPBKWYTXMI
|
6.5 | IC50 | 2 | — | |
JMWYXCOECNESCH
|
6.5 | IC50 | 2 | — | |
BLQYVHBZHAISJM
|
6.5 | Ki | 54 | — | |
NWMPVMMGSHXANZ
|
6.5 | Ki | 58 | — | |
OBHMNLIBIPFXCY
|
6.5 | Ki | 15 | — |