Target Details
| UniProt AC | P36507 |
|---|---|
| Gene Symbol | MAP2K2 |
| Protein Name | Dual specificity mitogen-activated protein kinase kinase 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 146
- Clinical molecules 16
- Avg pChEMBL 7.02
KEGG Pathways (80)
- Acute myeloid leukemia
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Chronic myeloid leukemia
- Colorectal cancer
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Phospholipase D signaling pathway
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (3)
Active Molecules (146)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SUDAHWBOROXANE
|
9.1 | IC50 | 2 | — | |
XXSSGBYXSKOLAM
|
8.8 | IC50 | 2 | — | |
GQAZGSHVSAGDOJ
|
8.8 | IC50 | 2 | — | |
LIRYPHYGHXZJBZ
|
8.6 | IC50 | 2 | — | |
PIZSULWGRRPCLE
|
8.4 | IC50 | 2 | — | |
UIARLYUEJFELEN
|
8.4 | Kd | 289 | Yes | |
FLBNLJLONKAPLR
|
8.4 | IC50 | 31 | — | |
FIMYFEGKMOCQKT
|
8.2 | Kd | 3 | — | |
OBWAXLNPVMNAMM
|
8.2 | IC50 | 2 | — | |
SBWCIJOOABLPME
|
8.2 | Ki | 13 | — | |
CJUVOUSLWUAKSP
|
8.2 | IC50 | 2 | — | |
MDRXVIUFICVQAF
|
8.2 | IC50 | 2 | — | |
CCKLGAATCPQJFO
|
8.1 | IC50 | 2 | — | |
ABSKEGXPTPLQJU
|
8.1 | IC50 | 2 | — | |
HDAJDNHIBCDLQF
|
8.1 | IC50 | 4 | — | |
NUTGQSGXRGUYMD
|
8.1 | IC50 | 2 | — | |
PJMVKCSXHOGMAD
|
8.0 | IC50 | 2 | — | |
ZLHOIUNYCFOMBY
|
8.0 | IC50 | 2 | — | |
UBPYILGKFZZVDX
|
8.0 | Kd | 130 | Yes | |
RWEVIPRMPFNTLO
|
8.0 | IC50 | 2 | — | |
QXPNJMHRUZCEAP
|
8.0 | IC50 | 14 | — | |
VNNQIPQHGQKABG
|
8.0 | IC50 | 2 | — | |
ACWZRVQXLIRSDF
|
7.9 | IC50 | 2 | — | |
ZCCPLJOKGAACRT
|
7.9 | Kd | 599 | — | |
CXQHYVUVSFXTMY
|
7.9 | Kd | 154 | — | |
SEJGTFPOEJWEGG
|
7.9 | Kd | 149 | — | |
VYFAUKUIHFXSHR
|
7.9 | IC50 | 2 | — | |
HUUPFBKNECWODN
|
7.8 | IC50 | 2 | — | |
INBLNUOYZJIQBN
|
7.8 | IC50 | 2 | — | |
YGTFAXJBDZZDJI
|
7.8 | IC50 | 2 | — | |
LTADFHIFJXCAPZ
|
7.8 | IC50 | 2 | — | |
RCLQNICOARASSR
|
7.7 | Kd | 2 | — | |
BSMCAPRUBJMWDF
|
7.7 | IC50 | 4 | — | |
YSSBOOQPHTZACI
|
7.7 | IC50 | 2 | — | |
YXJKFEHSDJWXFA
|
7.6 | IC50 | 2 | — | |
JWNPDZNEKVCWMY
|
7.6 | Kd | 57 | Yes | |
HKSZLNNOFSGOKW
|
7.5 | IC50 | 408 | — | |
HKSZLNNOFSGOKW
|
7.5 | Kd | 213 | — | |
ZYCRSZSZGOWJMO
|
7.5 | IC50 | 2 | — | |
COACPTNNJAFVAN
|
7.5 | IC50 | 2 | — | |
OQQZKLZIDXLDLJ
|
7.5 | IC50 | 2 | — | |
WDARYLSSWBWVCU
|
7.5 | Ki | 49 | — | |
VIUAUNHCRHHYNE
|
7.4 | Kd | 3 | — | |
DPEXRCOBPACFOO
|
7.4 | Ki | 36 | — | |
FWFGUZWWBVRJFF
|
7.4 | IC50 | 2 | — | |
XZXHXSATPCNXJR
|
7.4 | Kd | 165 | Yes | |
ROZUZKLWYFJFQI
|
7.3 | IC50 | 2 | — | |
XTHVWVXPQFNIMZ
|
7.3 | IC50 | 2 | — | |
RDSACQWTXKSHJT
|
7.3 | IC50 | 5 | — | |
FUMCKNCUEAQHCV
|
7.3 | Ki | 103 | — |