Target Details
| UniProt AC | P35568 |
|---|---|
| Gene Symbol | IRS1 |
| Protein Name | Insulin receptor substrate 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF02174 (IRS) PF00169 (PH) |
Summary
- Multi-target molecules 2
- Clinical molecules 0
- Avg pChEMBL 7.06
KEGG Pathways (21)
- AMPK signaling pathway
- Adipocytokine signaling pathway
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Autophagy - animal
- Diabetic cardiomyopathy
- FoxO signaling pathway
- Growth hormone synthesis, secretion and action
- Hormone signaling
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MicroRNAs in cancer
- Neurotrophin signaling pathway
- Non-alcoholic fatty liver disease
- PI3K-Akt signaling pathway
- Regulation of lipolysis in adipocytes
- Type II diabetes mellitus
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Top Co-occurrence Targets
- GAB1 2 shared
Active Molecules (2)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XQAPZSCMYFOATG
|
7.3 | Kd | 2 | — | |
AXOLRCIOEXAHNJ
|
6.8 | Kd | 2 | — |