Target Details
| UniProt AC | P31751 |
|---|---|
| Gene Symbol | AKT2 |
| Protein Name | RAC-beta serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00169 (PH) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 896
- Clinical molecules 7
- Avg pChEMBL 7.35
KEGG Pathways (103)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (4)
Active Molecules (896)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VLGIYSJSJHPDHN
|
8.0 | IC50 | 5 | — | |
DJKIPNZIOLJURK
|
7.9 | IC50 | 3 | — | |
PJXZRSDPJPHIOH
|
7.9 | IC50 | 4 | — | |
PRPNDHHOYWARPB
|
7.9 | IC50 | 2 | — | |
ULDXWLCXEDXJGE
|
7.9 | IC50 | 3 | — | |
WLXXUZBRYVKCGM
|
7.9 | IC50 | 2 | — | |
WPDHASUWSYKMLT
|
7.9 | IC50 | 2 | — | |
XMNABEGDUNNDFW
|
7.9 | IC50 | 5 | — | |
XONRTPBYDAFIRW
|
7.9 | IC50 | 9 | — | |
XQPFDQVEBGYLHB
|
7.9 | IC50 | 5 | — | |
YIOYTLIENRRHFN
|
7.9 | IC50 | 3 | — | |
ZDRLRDKZIJDUJJ
|
7.9 | IC50 | 2 | — | |
CHTMRWQLNNRRFJ
|
7.9 | Ki | 70 | — | |
UGXRNXXGEXPELZ
|
7.9 | IC50 | 2 | — | |
AQJWACKPYCXBCF
|
7.9 | IC50 | 4 | — | |
ATYOXMQKXVJYSG
|
7.9 | IC50 | 3 | — | |
GWYVKALUKYVOPI
|
7.9 | IC50 | 4 | — | |
KGPGFQWBCSZGEL
|
7.9 | IC50 | 4 | — | |
KGPGFQWBCSZGEL
|
7.9 | IC50 | 59 | Yes | |
RBZYXASPIFZSKF
|
7.9 | IC50 | 2 | — | |
UPXGPTVFECKXRX
|
7.9 | IC50 | 2 | — | |
JDUBGYFRJFOXQC
|
7.9 | IC50 | 5 | — | |
BNYDYQBGZMQWOX
|
7.8 | IC50 | 2 | — | |
GBFJUXFRUIRHLW
|
7.8 | IC50 | 2 | — | |
IHENXLOGIPZEHH
|
7.8 | IC50 | 3 | — | |
ILVKGSGRGSOAHZ
|
7.8 | IC50 | 3 | — | |
PXIAJBCYCFRMPI
|
7.8 | IC50 | 3 | — | |
QATMYBCFWXFYLG
|
7.8 | IC50 | 2 | — | |
SYYCIJCBSSCTSQ
|
7.8 | IC50 | 2 | — | |
VZOXJFOAJQVTTK
|
7.8 | IC50 | 4 | — | |
YUJQWKDHWHVRHF
|
7.8 | IC50 | 2 | — | |
SOQCDPYLBRSPBU
|
7.8 | IC50 | 2 | — | |
HELQJUWSTQCERT
|
7.8 | IC50 | 3 | — | |
JNHNQKIFPQKEFS
|
7.8 | IC50 | 3 | — | |
LUNBVUYIAYCSPQ
|
7.8 | IC50 | 2 | — | |
NANAONFNJKBZQE
|
7.8 | IC50 | 5 | — | |
NNIFDNQGXRCFDV
|
7.8 | IC50 | 5 | — | |
OXUDZYZUCUHCNU
|
7.8 | IC50 | 2 | — | |
RVLXAFFPKAXSFU
|
7.8 | IC50 | 4 | — | |
SRTFMGUPIBCWKP
|
7.8 | IC50 | 3 | — | |
UVHCRURXEOGIOT
|
7.8 | IC50 | 3 | — | |
YXJORAFRRFTOMV
|
7.8 | IC50 | 3 | — | |
QIMZVHOQNSASMQ
|
7.8 | IC50 | 2 | — | |
AXILYJJKIDQSFE
|
7.8 | IC50 | 3 | — | |
CIRLUEPNSNWHDA
|
7.8 | IC50 | 2 | — | |
HDUUMJRWZYXFRD
|
7.8 | IC50 | 2 | — | |
VEQOEEQRVZZGQZ
|
7.8 | Ki | 3 | — | |
VXYDJXMHISGSDA
|
7.8 | Ki | 59 | — | |
WNBFWWDKYZWYOX
|
7.8 | IC50 | 4 | — | |
YDQGQHBPNSJCQU
|
7.8 | IC50 | 2 | — |