Target Details
| UniProt AC | P31749 |
|---|---|
| Gene Symbol | AKT1 |
| Protein Name | RAC-alpha serine/threonine-protein kinase |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00169 (PH) PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 1,633
- Clinical molecules 105
- Avg pChEMBL 7.62
KEGG Pathways (103)
- AGE-RAGE signaling pathway in diabetic complications
- AMPK signaling pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Adrenergic signaling in cardiomyocytes
- Alcoholic liver disease
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- B cell receptor signaling pathway
- Breast cancer
- C-type lectin receptor signaling pathway
- Carbohydrate digestion and absorption
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Colorectal cancer
- Diabetic cardiomyopathy
- Dopaminergic synapse
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- Endometrial cancer
- Epstein-Barr virus infection
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Fluid shear stress and atherosclerosis
- Focal adhesion
- FoxO signaling pathway
- Gastric cancer
- Glioma
- Glucagon signaling pathway
- GnRH secretion
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IgSF CAM signaling
- Influenza A
- Insulin resistance
- Insulin signaling pathway
- Integrin signaling
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Lipid and atherosclerosis
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Measles
- Melanoma
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-alcoholic fatty liver disease
- Non-small cell lung cancer
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renal cell carcinoma
- Salmonella infection
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Small cell lung cancer
- Sphingolipid signaling pathway
- Spinocerebellar ataxia
- T cell receptor signaling pathway
- TNF signaling pathway
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- VEGF signaling pathway
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (6)
Active Molecules (1,633)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AFELNRHIXXVTNY
|
8.6 | IC50 | 2 | — | |
FQHMWPOPJGVXKJ
|
8.6 | IC50 | 2 | — | |
JKACOTYFJGVPGL
|
8.6 | IC50 | 2 | — | |
MNAVNDWRKFKOGX
|
8.6 | IC50 | 2 | — | |
MOYOONIFAFLCQH
|
8.6 | IC50 | 2 | — | |
UZZFEAONZIHMSX
|
8.6 | IC50 | 2 | — | |
ZHWCYSIHEZKFKK
|
8.6 | IC50 | 2 | — | |
ZRGLOCZGYSBBDT
|
8.6 | IC50 | 2 | — | |
NLAQVSZYBUGULE
|
8.6 | IC50 | 3 | — | |
AKLMWTZNFKEMQK
|
8.6 | IC50 | 2 | — | |
GGXVCKICZMCCLV
|
8.6 | IC50 | 2 | — | |
KIOZCJFPASJAIE
|
8.6 | IC50 | 2 | — | |
RMDQTUKUWQKGFZ
|
8.6 | IC50 | 2 | — | |
VWVSGSNEMFMEAE
|
8.6 | IC50 | 2 | — | |
WIFZRCVAOWEYQE
|
8.6 | IC50 | 3 | — | |
AUVWKQGXLMJMFV
|
8.5 | IC50 | 2 | — | |
BKWJTVGUNLNJRS
|
8.5 | IC50 | 2 | — | |
KRASTSBCSPTMCM
|
8.5 | IC50 | 2 | — | |
RMBLXWOYENNPNV
|
8.5 | IC50 | 2 | — | |
RVLXAFFPKAXSFU
|
8.5 | IC50 | 4 | — | |
VOMQQXSMYIYUPK
|
8.5 | IC50 | 2 | — | |
VZOXJFOAJQVTTK
|
8.5 | IC50 | 2 | — | |
WHPGUDAVAIYVRR
|
8.5 | IC50 | 4 | — | |
AXILYJJKIDQSFE
|
8.5 | IC50 | 3 | — | |
DILNBNMXKJXRQL
|
8.5 | IC50 | 3 | — | |
FUCRZGNUVYOQLJ
|
8.5 | IC50 | 2 | — | |
FUOAKEVEEQMCOF
|
8.5 | IC50 | 3 | — | |
IADWZPWKRCWMPE
|
8.5 | IC50 | 4 | — | |
JKZYASROJYTKEI
|
8.5 | IC50 | 3 | — | |
KGPGFQWBCSZGEL
|
8.5 | IC50 | 4 | — | |
MCLSMBVMAJFHIH
|
8.5 | IC50 | 2 | — | |
NFDAXVLLAADPOQ
|
8.5 | IC50 | 3 | — | |
NNIFDNQGXRCFDV
|
8.5 | IC50 | 5 | — | |
NPRGDRYIMFLLIG
|
8.5 | IC50 | 3 | — | |
NROLMFHMWLAKRA
|
8.5 | IC50 | 2 | — | |
RSPNZJWTRZTYCY
|
8.5 | IC50 | 3 | — | |
RZIDZIGAXXNODG
|
8.5 | IC50 | 5 | — | |
VLGIYSJSJHPDHN
|
8.5 | IC50 | 3 | — | |
WTFFQZJMEWAKGP
|
8.5 | IC50 | 3 | — | |
XJNOEUSVGFJGLV
|
8.5 | IC50 | 4 | — | |
XKNDLPMAXNMALL
|
8.5 | IC50 | 5 | — | |
XMRDIROQMJMYRD
|
8.5 | IC50 | 4 | — | |
YFXZFROOGCONFB
|
8.5 | IC50 | 3 | — | |
YZFPZLRYEFAFRR
|
8.5 | IC50 | 2 | — | |
NQEQTCICWVMQMO
|
8.5 | IC50 | 2 | — | |
OWOHMQRWTOYGDX
|
8.5 | IC50 | 2 | — | |
YQYPEKJWQWODNB
|
8.5 | IC50 | 2 | — | |
VXYDJXMHISGSDA
|
8.5 | Ki | 59 | — | |
AJHYNXPIENOPCI
|
8.5 | IC50 | 2 | — | |
DURJLTKEXQILNU
|
8.5 | IC50 | 2 | — |