Target Details
| UniProt AC | P29597 |
|---|---|
| Gene Symbol | TYK2 |
| Protein Name | Non-receptor tyrosine-protein kinase TYK2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 3,837
- Clinical molecules 19
- Avg pChEMBL 7.56
KEGG Pathways (17)
- Coronavirus disease - COVID-19
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human papillomavirus infection
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
Associated Diseases (2)
Active Molecules (3,837)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VQIIUJSNIKEMCK
|
9.1 | Ki | 4 | — | |
WBCXFXGRBXCTMB
|
9.1 | IC50 | 2 | — | |
QGBCMFRBRZOTMS
|
9.1 | IC50 | 4 | — | |
BEMLAJCOGNIHCJ
|
9.1 | Ki | 2 | — | |
NRHRWKIGNQTVOW
|
9.1 | IC50 | 4 | — | |
WCQVVINBTJFFGB
|
9.1 | IC50 | 4 | — | |
PYTYUNMFVXMLHB
|
9.1 | IC50 | 4 | — | |
BNYRMKQMDQUUAU
|
9.1 | IC50 | 4 | — | |
OETPUWNRYNOSLM
|
9.1 | IC50 | 2 | — | |
ONEVJHJFIVPBQA
|
9.1 | IC50 | 5 | — | |
OXYLNPXFNFUHGE
|
9.1 | IC50 | 4 | — | |
RIKRKORHVRUSHA
|
9.1 | IC50 | 2 | — | |
RSDFFPQIXSYTDD
|
9.1 | IC50 | 3 | — | |
SMDPPQPEXWEBHM
|
9.1 | IC50 | 4 | — | |
VRRAWTQKKRMNCS
|
9.1 | IC50 | 2 | — | |
FXTPMBKUURJDKQ
|
9.0 | IC50 | 3 | — | |
RDOBSVBMUCTXKO
|
9.0 | Ki | 2 | — | |
SPWAURFUZZSOJK
|
9.0 | IC50 | 4 | — | |
DOMVMISAWONYOX
|
9.0 | IC50 | 4 | — | |
OXZQZNRYJXBLDP
|
9.0 | IC50 | 4 | — | |
UEQMNZLWTUTJFC
|
9.0 | IC50 | 4 | — | |
FEQOESZUGZISHK
|
9.0 | IC50 | 9 | — | |
JRJOXBSULSBNJU
|
9.0 | Ki | 2 | — | |
BPENMBMNYYAYNC
|
9.0 | Ki | 4 | — | |
DWSHMTRKCGSRHM
|
9.0 | Ki | 4 | — | |
FTQBYQRDFCFCFN
|
9.0 | Ki | 4 | — | |
GSFSZEYURSLRNU
|
9.0 | Kd | 2 | — | |
HANGACPWNQHVPZ
|
9.0 | IC50 | 2 | — | |
IOVFFTMQWCOHDE
|
9.0 | Ki | 4 | — | |
JOTKUSGHYJSSQO
|
9.0 | Ki | 2 | — | |
KDDAYFKJJLUWTR
|
9.0 | IC50 | 4 | — | |
LXCJYFUAMDZSGA
|
9.0 | Ki | 4 | — | |
OIHUOYBHLAZFLD
|
9.0 | Ki | 4 | — | |
OYVOATNFWDYRPN
|
9.0 | IC50 | 4 | — | |
QLSJFVSWCVEOMO
|
9.0 | IC50 | 4 | — | |
QZHQFBVDTHQEOB
|
9.0 | Kd | 2 | — | |
UHNXPQNGFWCRNX
|
9.0 | IC50 | 3 | — | |
UUVRCVXQRKLYNN
|
9.0 | Ki | 4 | — | |
UUVRCVXQRKLYNN
|
9.0 | Ki | 4 | — | |
UWZLUJZCOIATJC
|
9.0 | Ki | 4 | — | |
UXQRKLKOTWVRMI
|
9.0 | IC50 | 4 | — | |
VNDWQCSOSCCWIP
|
9.0 | IC50 | 39 | Yes | |
JYSFPYSVGWPCBC
|
9.0 | IC50 | 4 | — | |
OZDFKECLFIDGPK
|
9.0 | IC50 | 4 | — | |
FFGWVYWABNYHRI
|
9.0 | IC50 | 2 | — | |
GJVBDBDAEXZQHK
|
9.0 | IC50 | 4 | — | |
PAAZQPKQXQHHEL
|
9.0 | IC50 | 3 | — | |
DLEBTAYWANKQTQ
|
9.0 | IC50 | 3 | — | |
GQULQVGPLLDCQB
|
9.0 | Ki | 2 | — | |
JEQHZFJUEIXQQT
|
9.0 | IC50 | 4 | — |