Target Details
| UniProt AC | P29474 |
|---|---|
| Gene Symbol | NOS3 |
| Protein Name | Nitric oxide synthase 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00667 (FAD_binding_1) PF00258 (Flavodoxin_1) PF00175 (NAD_binding_1) PF02898 (NO_synthase) |
Summary
- Multi-target molecules 94
- Clinical molecules 0
- Avg pChEMBL 6.5
KEGG Pathways (19)
- AGE-RAGE signaling pathway in diabetic complications
- Apelin signaling pathway
- Arginine and proline metabolism
- Arginine biosynthesis
- Calcium signaling pathway
- Diabetic cardiomyopathy
- Estrogen signaling pathway
- Fluid shear stress and atherosclerosis
- HIF-1 signaling pathway
- Insulin resistance
- Lipid and atherosclerosis
- Metabolic pathways
- Oxytocin signaling pathway
- PI3K-Akt signaling pathway
- Platelet activation
- Relaxin signaling pathway
- Sphingolipid signaling pathway
- VEGF signaling pathway
- cGMP-PKG signaling pathway
Associated Diseases (3)
Active Molecules (94)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
SEVICIFJHBFRBO
|
7.7 | Ki | 2 | — | |
XSSNABKEYXKKMK
|
7.7 | Ki | 3 | — | |
VVWWTGBEFOMQTM
|
7.6 | Ki | 3 | — | |
VFIZBHJTOHUOEK
|
7.4 | Ki | 3 | — | |
BRBUBVKGJRPRRD
|
7.3 | IC50 | 3 | — | |
HOYBUTQLFZKDDU
|
7.3 | IC50 | 2 | — | |
MSFKVTUZXYQWQW
|
7.3 | IC50 | 2 | — | |
QGCCHDIBMYPTPX
|
7.3 | IC50 | 3 | — | |
ASLZDSGYTVWLOQ
|
7.1 | IC50 | 2 | — | |
RMSWBHUVFNFNIZ
|
7.1 | Ki | 2 | — | |
TUOXPJFCQDMQOX
|
7.1 | IC50 | 3 | — | |
RWGGFJXJRPCCGD
|
7.1 | IC50 | 2 | — | |
JDRSQGJWTVRNGM
|
7.1 | Ki | 2 | — | |
VWCMAGONQJHIJZ
|
7.0 | Ki | 2 | — | |
KUZKVXUOMSVPOA
|
7.0 | Ki | 2 | — | |
IUFRDGFKAVLPFZ
|
7.0 | Ki | 2 | — | |
NNUPDBFRVPMTCH
|
6.9 | IC50 | 2 | — | |
GJHFAHVMZHRUFR
|
6.8 | IC50 | 2 | — | |
VMTPVCVORKDABN
|
6.8 | IC50 | 3 | — | |
ORLGLBZRQYOWNA
|
6.8 | IC50 | 3 | — | |
GGDLOMFAKKVDPT
|
6.8 | IC50 | 3 | — | |
BLKWYBIBFDPURB
|
6.7 | IC50 | 3 | — | |
CEFKRUHXJVFJLI
|
6.7 | IC50 | 3 | — | |
JIIBOYBTIWHZFJ
|
6.7 | IC50 | 3 | — | |
JIIBOYBTIWHZFJ
|
6.7 | IC50 | 2 | — | |
KWZJHWXZCUMXJX
|
6.7 | IC50 | 2 | — | |
MMGXDAVKLOGDHY
|
6.7 | IC50 | 3 | — | |
SJWHILBZPGQBJE
|
6.6 | IC50 | 2 | — | |
SRTDZDDEFUNXJL
|
6.6 | IC50 | 2 | — | |
NOSZXUXUBRDXQE
|
6.6 | IC50 | 2 | — | |
JQAXMIRHPUQOBI
|
6.6 | IC50 | 3 | — | |
MGMQUNKBBTVXOL
|
6.6 | Ki | 2 | — | |
SAVBRKWRKJJGCT
|
6.6 | IC50 | 3 | — | |
UUZNJASUYQZMDF
|
6.6 | Ki | 2 | — | |
DTVHKIMEQFHCIA
|
6.6 | Ki | 3 | — | |
RDYWNZRVHKWADW
|
6.5 | IC50 | 2 | — | |
RRCBYANJUIVMJX
|
6.5 | IC50 | 3 | — | |
MRAUNPAHJZDYCK
|
6.5 | IC50 | 3 | — | |
PPOHOXDDSDLEJO
|
6.5 | IC50 | 2 | — | |
PYGPVCGDWRVSFT
|
6.5 | Ki | 3 | — | |
OBEVPGRULCCSQA
|
6.5 | Ki | 3 | — | |
RFJKCAIXDAGEDH
|
6.4 | IC50 | 2 | — | |
SJAGNBCHAAJNEQ
|
6.4 | Ki | 2 | — | |
SKHVMUAVXNDFIZ
|
6.4 | IC50 | 2 | — | |
FODVLWUSSFCSRG
|
6.4 | Ki | 3 | — | |
LAXNJIWNBHHMDO
|
6.4 | Ki | 3 | — | |
NGVMVBQRKZPFLB
|
6.4 | IC50 | 3 | — | |
BETYXZSFUFTOLC
|
6.4 | Ki | 2 | — | |
ZOKOWWYVKANQNJ
|
6.4 | IC50 | 2 | — | |
JPLKZTMYLGJGRL
|
6.3 | IC50 | 2 | — |