Target Details
| UniProt AC | P28482 |
|---|---|
| Gene Symbol | MAPK1 |
| Protein Name | Mitogen-activated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 906
- Clinical molecules 33
- Avg pChEMBL 8.11
KEGG Pathways (120)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adherens junction
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Circadian entrainment
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- NOD-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Retrograde endocannabinoid signaling
- Salmonella infection
- Serotonergic synapse
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TGF-beta signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (906)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
JEQVYDMONHXBKT
|
8.5 | IC50 | 2 | — | |
NCSONJSKKZXWIR
|
8.5 | IC50 | 2 | — | |
OFMDSONOVVHNML
|
8.5 | IC50 | 2 | — | |
OSBIPPWRAXAMBO
|
8.5 | IC50 | 2 | — | |
ULJZOMIATBOYLC
|
8.5 | IC50 | 2 | — | |
UWHJOJFSLYJIJP
|
8.5 | IC50 | 2 | — | |
VKGZTIYOOVDXAF
|
8.5 | IC50 | 2 | — | |
BCARTBHHTNSUDU
|
8.5 | IC50 | 2 | — | |
IDXJXNORFKDAJG
|
8.5 | IC50 | 2 | — | |
OSVXRFQNFDFQOR
|
8.5 | IC50 | 2 | — | |
VBZBYPVAXCQWLJ
|
8.5 | IC50 | 2 | — | |
XISPMPFADBEOOK
|
8.5 | IC50 | 2 | — | |
CBOKAHPZUANSEE
|
8.5 | IC50 | 2 | — | |
FDLYAVNIMZVGOU
|
8.5 | Ki | 3 | — | |
HGNXTQDUTZQGAT
|
8.5 | IC50 | 2 | — | |
IAMJTRVIGIYNCB
|
8.5 | IC50 | 2 | — | |
ITDYINMSJNIYQN
|
8.5 | IC50 | 2 | — | |
KDGGQHGWEXXQMX
|
8.5 | IC50 | 2 | — | |
PFQOMZPHMUINBU
|
8.5 | IC50 | 2 | — | |
QJBMWGZRUUEZHG
|
8.5 | IC50 | 2 | — | |
RKLSWXHLRPBNDG
|
8.5 | IC50 | 2 | — | |
RZUOCXOYPYGSKL
|
8.5 | IC50 | 8 | — | |
SADYKTMEVCDLDO
|
8.5 | IC50 | 2 | — | |
AJHZVRDFBUABNE
|
8.5 | IC50 | 2 | — | |
BADBXOLDRLKIDT
|
8.5 | IC50 | 2 | — | |
DZPZWQNPTSKKAG
|
8.5 | IC50 | 2 | — | |
FCBRBTSGPCWMSK
|
8.5 | IC50 | 2 | — | |
FGICBWVDPGKCBW
|
8.5 | IC50 | 2 | — | |
KAEBLGCBBNJALL
|
8.5 | IC50 | 2 | — | |
PYKOTVUQLKQSBL
|
8.5 | IC50 | 2 | — | |
GDENZVFEXVRWNZ
|
8.5 | IC50 | 2 | — | |
HZOJZTFEDPTFSO
|
8.5 | IC50 | 2 | — | |
IBRKIEOOAVIRDE
|
8.5 | IC50 | 2 | — | |
XHQBOSUFOHFXGZ
|
8.5 | IC50 | 2 | — | |
DECXTCNNSOQVGW
|
8.4 | IC50 | 2 | — | |
DKUZBXNXNHWZKA
|
8.4 | IC50 | 2 | — | |
FFIXPGHLJZZNIW
|
8.4 | IC50 | 2 | — | |
FNLSJKPQJLPUGU
|
8.4 | IC50 | 2 | — | |
FTYNGPOXJWSFOU
|
8.4 | IC50 | 2 | — | |
HDOIIVMUNLLSLM
|
8.4 | IC50 | 2 | — | |
ILSJLXUKMFFJNT
|
8.4 | IC50 | 2 | — | |
MUIRGWYXZWMYQP
|
8.4 | IC50 | 2 | — | |
DMJRSLQZVMDZQM
|
8.4 | IC50 | 2 | — | |
TYQOIFDVJMCWNW
|
8.4 | IC50 | 2 | — | |
UKRMPOCRDFMSGJ
|
8.4 | IC50 | 2 | — | |
VYTGIYXPWUXYOK
|
8.4 | IC50 | 2 | — | |
XJNNUINBYKQHBT
|
8.4 | IC50 | 2 | — | |
CBDGAYOSNQGGCK
|
8.4 | IC50 | 2 | — | |
DTQBPUUFXNNLER
|
8.4 | IC50 | 2 | — | |
DZKFJBACCWTQSQ
|
8.4 | IC50 | 4 | — |