Target Details
| UniProt AC | P28482 |
|---|---|
| Gene Symbol | MAPK1 |
| Protein Name | Mitogen-activated protein kinase 1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 906
- Clinical molecules 33
- Avg pChEMBL 8.11
KEGG Pathways (120)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adherens junction
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Circadian entrainment
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- NOD-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Retrograde endocannabinoid signaling
- Salmonella infection
- Serotonergic synapse
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TGF-beta signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Associated Diseases (1)
Active Molecules (906)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
XJNNUINBYKQHBT
|
8.3 | IC50 | 2 | — | |
DBXXOIIQTTULBZ
|
8.3 | IC50 | 2 | — | |
OEXCDEUJESZFMP
|
8.3 | IC50 | 2 | — | |
QECSLTSUPKPCOK
|
8.3 | IC50 | 2 | — | |
CLLWUPCFDBDWON
|
8.3 | IC50 | 2 | — | |
DUXSJWIIUXEQQE
|
8.3 | IC50 | 2 | — | |
SLPSOQSJJLVJPX
|
8.3 | IC50 | 2 | — | |
ABMBHMCFCIMYPD
|
8.2 | IC50 | 2 | — | |
MRHUCFAJTNKMCG
|
8.2 | IC50 | 2 | — | |
AJJXVUYRBFSJTL
|
8.2 | IC50 | 2 | — | |
ATLBSXNUGRIZMX
|
8.2 | IC50 | 2 | — | |
FIMYFEGKMOCQKT
|
8.2 | IC50 | 3 | — | |
LYNNMPUJGGOPNR
|
8.2 | IC50 | 2 | — | |
MGVUJEYASWNENB
|
8.2 | IC50 | 2 | — | |
ULOBOPPHTKWOKZ
|
8.2 | IC50 | 2 | — | |
YYVXMNUUBXXDSP
|
8.2 | IC50 | 2 | — | |
JANWFYDVPDDQHC
|
8.2 | IC50 | 2 | — | |
JBFJLZSRJTYSON
|
8.2 | IC50 | 2 | — | |
JPPZQBFIHPEKKB
|
8.2 | IC50 | 2 | — | |
OALGIVXCUSEONF
|
8.2 | IC50 | 2 | — | |
QDULKFTXPAMMHU
|
8.2 | IC50 | 2 | — | |
ATBAETXFFCOZOY
|
8.2 | IC50 | 3 | — | |
ATBAETXFFCOZOY
|
8.2 | IC50 | 10 | — | |
QNHMLINXJJNRFH
|
8.2 | IC50 | 2 | — | |
URLQCJFKEIJEMW
|
8.2 | IC50 | 3 | — | |
CELAWHXBDAYIJN
|
8.2 | IC50 | 2 | — | |
DPIVWFZQDHRAJT
|
8.2 | IC50 | 2 | — | |
DPIVWFZQDHRAJT
|
8.2 | IC50 | 2 | — | |
LKSCUIYYIYTNTE
|
8.2 | IC50 | 2 | — | |
YALKVBDBNYJVTM
|
8.2 | IC50 | 2 | — | |
YNSQFVJJPOAFKI
|
8.2 | IC50 | 2 | — | |
NWGBRDDTFZTOOA
|
8.2 | IC50 | 2 | — | |
RTMAZSIJEAZCLA
|
8.2 | IC50 | 3 | — | |
SYCYKCJYHIDUFW
|
8.2 | IC50 | 2 | — | |
KMVDGCBYEJXIME
|
8.2 | IC50 | 2 | — | |
RHWBFUUOJDPUFF
|
8.2 | IC50 | 2 | — | |
RJDPHHSYOWPVDU
|
8.2 | IC50 | 2 | — | |
WQZCQSZZPWAGRX
|
8.2 | IC50 | 2 | — | |
ZBKJIOFGFMYADW
|
8.2 | IC50 | 2 | — | |
UFPJNNFZCVYLKA
|
8.2 | IC50 | 2 | — | |
WKCBVILIRPPILQ
|
8.2 | IC50 | 2 | — | |
IGHNXDJXBMWOGQ
|
8.2 | IC50 | 2 | — | |
LKKAUKLMPFMADW
|
8.2 | IC50 | 2 | — | |
PLISQNKSEJBHFZ
|
8.2 | IC50 | 2 | — | |
PRWOTQUYNWSNFC
|
8.2 | Ki | 4 | — | |
SQFDTJDOPKUHOK
|
8.2 | Ki | 3 | — | |
WIXXOCCJPBPLGM
|
8.2 | IC50 | 2 | — | |
ZENIUFRGSIDYDD
|
8.2 | IC50 | 2 | — | |
MEMCTQHLJNUYLA
|
8.2 | IC50 | 2 | — | |
UCUOLKPPCUZTEC
|
8.2 | IC50 | 2 | — |