Target Details
| UniProt AC | P27361 |
|---|---|
| Gene Symbol | MAPK3 |
| Protein Name | Mitogen-activated protein kinase 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 234
- Clinical molecules 6
- Avg pChEMBL 7.26
KEGG Pathways (120)
- AGE-RAGE signaling pathway in diabetic complications
- Acute myeloid leukemia
- Adherens junction
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone-regulated sodium reabsorption
- Alzheimer disease
- Apelin signaling pathway
- Apoptosis
- Autophagy - animal
- Axon guidance
- B cell receptor signaling pathway
- Bladder cancer
- Breast cancer
- C-type lectin receptor signaling pathway
- Cadherin signaling
- Cellular senescence
- Central carbon metabolism in cancer
- Chagas disease
- Chemical carcinogenesis - reactive oxygen species
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Choline metabolism in cancer
- Cholinergic synapse
- Chronic myeloid leukemia
- Circadian entrainment
- Colorectal cancer
- Coronavirus disease - COVID-19
- Cushing syndrome
- EGFR tyrosine kinase inhibitor resistance
- Efferocytosis
- Endocrine resistance
- Endometrial cancer
- ErbB signaling pathway
- Estrogen signaling pathway
- Fc epsilon RI signaling pathway
- Fc gamma R-mediated phagocytosis
- Focal adhesion
- FoxO signaling pathway
- Gap junction
- Gastric cancer
- Glioma
- Glutamatergic synapse
- GnRH secretion
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- HIF-1 signaling pathway
- Hepatitis B
- Hepatitis C
- Hepatocellular carcinoma
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- IL-17 signaling pathway
- IgSF CAM signaling
- Influenza A
- Insulin signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Lipid and atherosclerosis
- Long-term depression
- Long-term potentiation
- MAPK signaling pathway
- Melanogenesis
- Melanoma
- MicroRNAs in cancer
- NOD-like receptor signaling pathway
- Natural killer cell mediated cytotoxicity
- Neurotrophin signaling pathway
- Neutrophil extracellular trap formation
- Non-small cell lung cancer
- Oocyte meiosis
- Osteoclast differentiation
- Oxytocin signaling pathway
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Parathyroid hormone synthesis, secretion and action
- Pathogenic Escherichia coli infection
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Pertussis
- Phospholipase D signaling pathway
- Platelet activation
- Platinum drug resistance
- Prion disease
- Progesterone-mediated oocyte maturation
- Prolactin signaling pathway
- Prostate cancer
- Proteoglycans in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Relaxin signaling pathway
- Renal cell carcinoma
- Retrograde endocannabinoid signaling
- Salmonella infection
- Serotonergic synapse
- Shigellosis
- Signaling pathways regulating pluripotency of stem cells
- Sphingolipid signaling pathway
- T cell receptor signaling pathway
- TGF-beta signaling pathway
- TNF signaling pathway
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Thyroid cancer
- Thyroid hormone signaling pathway
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Type II diabetes mellitus
- VEGF signaling pathway
- Vascular smooth muscle contraction
- Viral carcinogenesis
- Yersinia infection
- cAMP signaling pathway
- cGMP-PKG signaling pathway
- mTOR signaling pathway
Active Molecules (234)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NBNHPUXLHVMNEK
|
7.4 | IC50 | 2 | — | |
DZKFJBACCWTQSQ
|
7.4 | IC50 | 4 | — | |
UHRFQLODOGBNCC
|
7.4 | IC50 | 2 | — | |
HDAJDNHIBCDLQF
|
7.4 | IC50 | 14 | — | |
PZERAHOWFARGGG
|
7.4 | IC50 | 4 | — | |
BCLCGBYHHJIGFR
|
7.4 | IC50 | 2 | — | |
CZSJKHCGJOLSDZ
|
7.4 | IC50 | 2 | — | |
NMVOJGCTNLHEFK
|
7.4 | IC50 | 2 | — | |
SBBYUKLIZAGFLI
|
7.4 | IC50 | 2 | — | |
QTZUMCMRRPENJM
|
7.3 | IC50 | 3 | — | |
QXMPFULBALJFJX
|
7.3 | IC50 | 3 | — | |
ANAUUYFWVFDXFS
|
7.3 | IC50 | 2 | — | |
RZCDDUDKDKUXLC
|
7.3 | IC50 | 3 | — | |
PGGLRAWFUJMQBN
|
7.3 | IC50 | 4 | — | |
HNYYFWGWLSEHQF
|
7.3 | IC50 | 3 | — | |
OMKSHRGIEVKCAP
|
7.3 | IC50 | 2 | — | |
BBCPGZQFIGPLPC
|
7.3 | IC50 | 2 | — | |
RXOAUTDNEHGRQR
|
7.2 | IC50 | 2 | — | |
CNWPAKCFVFDYQN
|
7.2 | IC50 | 3 | — | |
MEPJUBFFZUKRSK
|
7.2 | IC50 | 4 | — | |
UMEKRJBKRPLHKL
|
7.2 | IC50 | 3 | — | |
XETBCFSFVAVHSU
|
7.2 | IC50 | 3 | — | |
OPWJOSHVFLEUHZ
|
7.2 | IC50 | 2 | — | |
DEZZLWQELQORIU
|
7.2 | IC50 | 7 | — | |
DNSZJAFGHJNCIE
|
7.2 | IC50 | 3 | — | |
COSHZQYMYFJMAZ
|
7.2 | IC50 | 2 | — | |
DIJMZIXDGKPCOI
|
7.2 | IC50 | 2 | — | |
FZVDMPMSYYNXLJ
|
7.2 | IC50 | 3 | — | |
JXDQJNOCFPWRNA
|
7.2 | IC50 | 2 | — | |
PRQMKPLDKYLQOM
|
7.1 | IC50 | 2 | — | |
RLPHZKNHLMYKNY
|
7.1 | IC50 | 2 | — | |
XGNWLLMQVIIJHG
|
7.1 | IC50 | 2 | — | |
XMKOQLRLHXRXQD
|
7.1 | IC50 | 2 | — | |
YPLHAXDRIIJALD
|
7.1 | IC50 | 3 | — | |
CAIDLKSVZKWPJK
|
7.1 | IC50 | 3 | — | |
GHSFSJOGDCXHAZ
|
7.1 | IC50 | 2 | — | |
KBPYMFSSFLOJPH
|
7.1 | IC50 | 4 | — | |
PZERAHOWFARGGG
|
7.1 | IC50 | 4 | — | |
BDIRGDVPAXGXBM
|
7.1 | IC50 | 4 | — | |
BRSBEEDGRKMCQT
|
7.1 | IC50 | 4 | — | |
YEGUKZXZMMRPDN
|
7.1 | IC50 | 4 | — | |
ZLEYPUJZZGTSLW
|
7.1 | IC50 | 3 | — | |
BGZRPCJRWKJCDU
|
7.1 | IC50 | 4 | — | |
FKHMCPBCFQIVRS
|
7.1 | IC50 | 2 | — | |
HHXOZCGECKUWEO
|
7.0 | IC50 | 2 | — | |
NBZFRTJWEIHFPF
|
7.0 | Kd | 3 | — | |
UMCRTOONIKKCKZ
|
7.0 | IC50 | 4 | — | |
VPQNTXFFSYPIID
|
7.0 | IC50 | 4 | — | |
UEMWDQVZICMXHX
|
7.0 | IC50 | 2 | — | |
HJWORTJKQYPPQB
|
7.0 | IC50 | 2 | — |