Target Details
| UniProt AC | P25054 |
|---|---|
| Gene Symbol | APC |
| Protein Name | Adenomatous polyposis coli protein |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF05972 (APC_15aa) PF05956 (APC_basic) PF16689 (APC_N_CC) PF05923 (APC_r) PF18797 (APC_rep) PF16634 (APC_u13) PF16635 (APC_u14) PF16636 (APC_u15) PF16630 (APC_u5) PF16633 (APC_u9) PF00514 (Arm) PF16629 (Arm_APC_u3) PF05937 (EB1_binding) PF05924 (SAMP) PF11414 (Suppressor_APC) |
Summary
- Multi-target molecules 6
- Clinical molecules 0
- Avg pChEMBL 7.75
KEGG Pathways (17)
- Alzheimer disease
- Basal cell carcinoma
- Breast cancer
- Cadherin signaling
- Colorectal cancer
- Cushing syndrome
- Endometrial cancer
- Gastric cancer
- Hepatocellular carcinoma
- Hippo signaling pathway
- Human papillomavirus infection
- MicroRNAs in cancer
- Pathways in cancer
- Pathways of neurodegeneration - multiple diseases
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
- Wnt signaling pathway
Associated Diseases (10)
Top Co-occurrence Targets
- CTNNBIP1 6 shared
Active Molecules (6)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NLHLTJBMDYFGJM
|
8.9 | IC50 | 2 | — | |
ROSWIQHOISBZCD
|
8.4 | IC50 | 2 | — | |
YBBUGSYNPXTSGW
|
7.9 | IC50 | 2 | — | |
MQYKHRCDYACKTE
|
7.7 | IC50 | 2 | — | |
WMEDEBADCHNVEO
|
7.0 | IC50 | 2 | — | |
ULWIWKNRZYQIBH
|
6.6 | IC50 | 2 | — |