Target Details
| UniProt AC | P23458 |
|---|---|
| Gene Symbol | JAK1 |
| Protein Name | Tyrosine-protein kinase JAK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 8,920
- Clinical molecules 14
- Avg pChEMBL 8.26
KEGG Pathways (28)
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (8,920)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
ZRWAPJQBKMIZOF
|
10.0 | IC50 | 4 | — | |
ZZQVYWMBZOKZII
|
10.0 | IC50 | 4 | — | |
ZZZCJPNLVAXXNC
|
10.0 | IC50 | 2 | — | |
OTBGXODPXJHIIB
|
10.0 | IC50 | 2 | — | |
WXKHYZJBGITZPX
|
10.0 | IC50 | 2 | — | |
AYSPNZYVJHZGIG
|
10.0 | Ki | 4 | — | |
DQOSTQVAQJUSJW
|
10.0 | IC50 | 2 | — | |
FOIOAHKFRGNAMO
|
10.0 | Ki | 2 | — | |
FZXMPCXMYBNDEB
|
10.0 | IC50 | 4 | — | |
HSHNFLXETCFKET
|
10.0 | IC50 | 2 | — | |
JZVSJKDPNLMIES
|
10.0 | IC50 | 2 | — | |
LBSGMMYTHHZKMA
|
10.0 | Ki | 2 | — | |
LDAVCWRDFVEWLN
|
10.0 | IC50 | 2 | — | |
LNDOFTXPTPMZBR
|
10.0 | IC50 | 2 | — | |
PCBXBEAUPXYULI
|
10.0 | IC50 | 2 | — | |
RPBFJNXYGYUMOI
|
10.0 | Ki | 2 | — | |
WNQLUPXENRSFJM
|
10.0 | IC50 | 2 | — | |
YPWJXZWSFKFYJI
|
10.0 | Ki | 2 | — | |
ZGTGVGIFPHRGJP
|
10.0 | IC50 | 2 | — | |
KAIMQQXRVFLUNQ
|
9.9 | IC50 | 2 | — | |
LBFQOESLJMTEIV
|
9.9 | Ki | 2 | — | |
XQDJIZPXYHDJDG
|
9.9 | IC50 | 3 | — | |
AKKMNVYVOCEDET
|
9.9 | Ki | 2 | — | |
AZXMOJFOZVXJNF
|
9.9 | IC50 | 2 | — | |
CUCSAIMVBJISSF
|
9.9 | IC50 | 2 | — | |
DKFMXHXDTZQTJB
|
9.9 | IC50 | 2 | — | |
DUNMNNOSTARHFC
|
9.9 | Ki | 2 | — | |
FLGSHNZVBRJGFQ
|
9.9 | IC50 | 2 | — | |
HNZKLAYIYJMAQL
|
9.9 | IC50 | 2 | — | |
HOMAJRFFAOZJQW
|
9.9 | IC50 | 2 | — | |
KHOTXVKXPBBUFY
|
9.9 | IC50 | 2 | — | |
LIWWZPGNFLTTAB
|
9.9 | Ki | 2 | — | |
MFWQXZZXOUIDTN
|
9.9 | IC50 | 4 | — | |
MVBHRZHKVRTKFA
|
9.9 | Ki | 2 | — | |
PBIKGHGVORQLAM
|
9.9 | IC50 | 2 | — | |
PKXPHRNQVJASEZ
|
9.9 | IC50 | 2 | — | |
QPZAYQIDTOLOAC
|
9.9 | IC50 | 2 | — | |
ROCWQSCNNATQOY
|
9.9 | Ki | 4 | — | |
VAMFLRJFNWJPOZ
|
9.9 | IC50 | 2 | — | |
VJNXRHULTYEOJX
|
9.9 | IC50 | 2 | — | |
WJQJIRFTISUOGY
|
9.9 | IC50 | 2 | — | |
XTJSNJANOUEBPN
|
9.9 | IC50 | 2 | — | |
XYWSGRBSDRLPMO
|
9.9 | IC50 | 2 | — | |
ZETDVJIEROUNIC
|
9.9 | Ki | 2 | — | |
ZGKVCIRKBHBELA
|
9.9 | IC50 | 2 | — | |
ZGTGVGIFPHRGJP
|
9.9 | IC50 | 2 | — | |
ZOVFXZRZZQIOQN
|
9.9 | IC50 | 2 | — | |
HKZKUYDLAQQSJQ
|
9.9 | Ki | 2 | — | |
DFOIUBUTPNSVFY
|
9.9 | IC50 | 2 | — | |
DMUFLBWGQPRKBS
|
9.9 | IC50 | 2 | — |