Target Details
| UniProt AC | P23458 |
|---|---|
| Gene Symbol | JAK1 |
| Protein Name | Tyrosine-protein kinase JAK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 8,920
- Clinical molecules 14
- Avg pChEMBL 8.26
KEGG Pathways (28)
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (8,920)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KBUFRYLIBNBLOU
|
10.1 | Ki | 2 | — | |
MLUQXJNMRUQORU
|
10.1 | Ki | 2 | — | |
MTNOHNLEHSEDJU
|
10.1 | IC50 | 2 | — | |
NJBYWAFMJPRGGH
|
10.1 | IC50 | 2 | — | |
OQDGVIXOMPQWQW
|
10.1 | IC50 | 2 | — | |
QPBWRFLJCZNADY
|
10.1 | IC50 | 2 | — | |
QPBWRFLJCZNADY
|
10.1 | IC50 | 4 | — | |
QPZAYQIDTOLOAC
|
10.1 | IC50 | 2 | — | |
QRZRGWMGZPUVIL
|
10.1 | IC50 | 2 | — | |
RKCWWRVQGOCAKM
|
10.1 | IC50 | 2 | — | |
RSRGZFZZRNZHGT
|
10.1 | IC50 | 2 | — | |
RTKMRSGMVJFPCF
|
10.1 | IC50 | 2 | — | |
SSSAOGAUOMGVOS
|
10.1 | IC50 | 2 | — | |
VIXFOWRGZQRQKV
|
10.1 | IC50 | 2 | — | |
VPHZZZUYGUIRIN
|
10.1 | IC50 | 2 | — | |
XALZGMWZXRRZFQ
|
10.1 | IC50 | 2 | — | |
YGXMZSBLHVDPRZ
|
10.1 | IC50 | 2 | — | |
YKJUCYZKVUYVKX
|
10.1 | IC50 | 2 | — | |
ZAKJHWPSWSAOJC
|
10.1 | IC50 | 2 | — | |
ZEMKOQGKMADMOM
|
10.1 | IC50 | 2 | — | |
IEZCQRWUHVGNAJ
|
10.0 | IC50 | 4 | — | |
RYETZJKNDURPJI
|
10.0 | IC50 | 2 | — | |
DHWQGOLXINKFNQ
|
10.0 | IC50 | 4 | — | |
AATRYKZHNGYMOX
|
10.0 | IC50 | 4 | — | |
ABUVOXROFVLDEY
|
10.0 | IC50 | 2 | — | |
AFDOVZOKEJRGOW
|
10.0 | IC50 | 2 | — | |
AMQJRDKUJJLKCK
|
10.0 | Ki | 2 | — | |
AXKWTDGUBMKLRN
|
10.0 | IC50 | 2 | — | |
BIUZUMXNKSQCFI
|
10.0 | Ki | 4 | — | |
BSZMEVIVQFVLAH
|
10.0 | IC50 | 2 | — | |
CTGZLXGHFXANQC
|
10.0 | IC50 | 2 | — | |
CUOWQRBLXGZKTO
|
10.0 | IC50 | 4 | — | |
DQSILYTXROORLC
|
10.0 | Ki | 2 | — | |
DRLOGZHQVDXOPP
|
10.0 | IC50 | 2 | — | |
DTDRXQSNAPUYPB
|
10.0 | IC50 | 2 | — | |
DTDRXQSNAPUYPB
|
10.0 | IC50 | 2 | — | |
DZYJQAKCPQYEKD
|
10.0 | IC50 | 4 | — | |
DZYJQAKCPQYEKD
|
10.0 | IC50 | 4 | — | |
FAHHTFRZVMZMPC
|
10.0 | IC50 | 2 | — | |
FBMPIPDDIOMXIM
|
10.0 | IC50 | 4 | — | |
FMJVBOXWJGDNJK
|
10.0 | IC50 | 4 | — | |
FOPCXFZCJYPJSG
|
10.0 | IC50 | 2 | — | |
FPYHDWUSAOFILC
|
10.0 | IC50 | 2 | — | |
GQDKZKSLBHKUGR
|
10.0 | IC50 | 4 | — | |
GSNGNPFBGJFBFO
|
10.0 | IC50 | 2 | — | |
GXGBKKFEKDDZKF
|
10.0 | IC50 | 2 | — | |
GYSAXDBJNHZIQI
|
10.0 | IC50 | 2 | — | |
HBQWOCBODGSDEL
|
10.0 | IC50 | 2 | — | |
HFIMQKPETJSAHQ
|
10.0 | IC50 | 2 | — | |
HRABTOLYNILDJT
|
10.0 | IC50 | 2 | — |