Target Details
| UniProt AC | P23458 |
|---|---|
| Gene Symbol | JAK1 |
| Protein Name | Tyrosine-protein kinase JAK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 8,920
- Clinical molecules 14
- Avg pChEMBL 8.26
KEGG Pathways (28)
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (8,920)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VCCJOVKEVJPDTQ
|
10.2 | IC50 | 2 | — | |
VNYSRXOYTNGAEJ
|
10.2 | IC50 | 2 | — | |
VTHLBHXTIANZQX
|
10.2 | IC50 | 4 | — | |
YNJSNNAMLJBQCZ
|
10.2 | IC50 | 2 | — | |
SIDAYICSLPDCMZ
|
10.1 | IC50 | 2 | — | |
JOKKEFYHRTWHHC
|
10.1 | Ki | 4 | — | |
MDTIFFXIWIDZBH
|
10.1 | IC50 | 4 | — | |
AMQJRDKUJJLKCK
|
10.1 | Ki | 2 | — | |
CAHYIXKHAUSRRA
|
10.1 | IC50 | 2 | — | |
RLMMSHIOBVKROE
|
10.1 | IC50 | 4 | — | |
AMBGBDGUUYGEJS
|
10.1 | Ki | 4 | — | |
CBMGCCOYSLQIGL
|
10.1 | IC50 | 2 | — | |
CNLCAZXJGQVMJI
|
10.1 | Ki | 2 | — | |
CQVLTKQROAIZOC
|
10.1 | Ki | 4 | — | |
CQVLTKQROAIZOC
|
10.1 | Ki | 2 | — | |
CWJRLHXOIKTESS
|
10.1 | IC50 | 2 | — | |
FCWDCSBCUQREKU
|
10.1 | Ki | 2 | — | |
FRZCZWJZDMDTOB
|
10.1 | Ki | 2 | — | |
GPOGKSDOWYRIMA
|
10.1 | Ki | 2 | — | |
IONPPIMDIANTLK
|
10.1 | IC50 | 2 | — | |
IPLMSZREQBRRBS
|
10.1 | IC50 | 2 | — | |
LCHGXWXNRFSDDK
|
10.1 | IC50 | 2 | — | |
NAUJWIXWAOOQNK
|
10.1 | IC50 | 2 | — | |
NPXRGBHWBLKOFJ
|
10.1 | Ki | 4 | — | |
NSQHXILTPOSWFU
|
10.1 | IC50 | 2 | — | |
OITNIWDKWPKAAP
|
10.1 | IC50 | 2 | — | |
OUFHYGMICYVPJO
|
10.1 | Ki | 2 | — | |
PJTVQALTARBQFE
|
10.1 | Ki | 2 | — | |
PQZNMXSRCTZPLQ
|
10.1 | IC50 | 2 | — | |
QBRUCNASNDEFKL
|
10.1 | IC50 | 2 | — | |
RBAFSDHPEDEWAE
|
10.1 | IC50 | 2 | — | |
SNNXBVPXCIVTOK
|
10.1 | IC50 | 2 | — | |
SWDCGNWJGSTJJB
|
10.1 | IC50 | 2 | — | |
UWZLUJZCOIATJC
|
10.1 | Ki | 4 | — | |
XARCLNXNXKOMHG
|
10.1 | IC50 | 2 | — | |
XJYIAUXZPZHRGV
|
10.1 | Ki | 2 | — | |
XJYIAUXZPZHRGV
|
10.1 | Ki | 2 | — | |
HJVNBZSJPWXICA
|
10.1 | IC50 | 4 | — | |
VTXMTPPGODARDG
|
10.1 | IC50 | 4 | — | |
OEMOIOUFFOLZQP
|
10.1 | IC50 | 4 | — | |
BGLUIKXULQMNGE
|
10.1 | IC50 | 2 | — | |
BVUGRHVHUUVYDJ
|
10.1 | IC50 | 2 | — | |
DKDNJGFHLADIOQ
|
10.1 | IC50 | 2 | — | |
DNWOWZCLGNAEIL
|
10.1 | IC50 | 2 | — | |
FIWZXYWXBGFQSA
|
10.1 | Ki | 2 | — | |
GUVNMXUCKBQQCC
|
10.1 | IC50 | 2 | — | |
HICJIUGQVXQINW
|
10.1 | Ki | 2 | — | |
HUSUQTKIWPEOGP
|
10.1 | IC50 | 2 | — | |
IUSHFHFQXQXSQX
|
10.1 | IC50 | 2 | — | |
JWHFFSSHJCWKJU
|
10.1 | IC50 | 2 | — |