Target Details
| UniProt AC | P23458 |
|---|---|
| Gene Symbol | JAK1 |
| Protein Name | Tyrosine-protein kinase JAK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 8,920
- Clinical molecules 14
- Avg pChEMBL 8.26
KEGG Pathways (28)
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (8,920)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
VBIIHZOALUSRNV
|
11.0 | IC50 | 4 | — | |
YYUFVSMURUQLMO
|
11.0 | IC50 | 4 | — | |
PYTYUNMFVXMLHB
|
10.9 | IC50 | 4 | — | |
IRIDDEHSOPFQKO
|
10.9 | IC50 | 4 | — | |
QAHCNFSHWLDZBS
|
10.9 | IC50 | 4 | — | |
QATVMVPAHQPMOK
|
10.9 | IC50 | 4 | — | |
VERTWIIVDDOBSG
|
10.9 | IC50 | 4 | — | |
VRYUZSRAENQEKH
|
10.9 | IC50 | 4 | — | |
WZHKRYGGBXNTMW
|
10.9 | IC50 | 4 | — | |
ASKVWNDKMHFVHL
|
10.9 | IC50 | 4 | — | |
BPDXDZDEFQATRW
|
10.9 | IC50 | 4 | — | |
CYFYEGKSPAEQGC
|
10.9 | IC50 | 4 | — | |
HJPUXRUWOGLSHD
|
10.9 | IC50 | 4 | — | |
KRLPVQAMTJYSFK
|
10.9 | IC50 | 3 | — | |
LUVSHWSDJWZREL
|
10.9 | IC50 | 4 | — | |
GPVUZLBZXFYXOK
|
10.8 | IC50 | 4 | — | |
RSDFFPQIXSYTDD
|
10.8 | IC50 | 3 | — | |
SJAPARWBVYBGJO
|
10.8 | IC50 | 4 | — | |
LSQWGVOEBUCSKN
|
10.8 | IC50 | 4 | — | |
PPUCWLVSPNIYBQ
|
10.8 | IC50 | 4 | — | |
SCWPVGKRRGXLMF
|
10.8 | IC50 | 4 | — | |
XQZMCWSNDJGPHN
|
10.8 | IC50 | 4 | — | |
FGMDTAYCXKEAOG
|
10.8 | IC50 | 3 | — | |
IEZCQRWUHVGNAJ
|
10.8 | IC50 | 4 | — | |
JIQQEQXPBPQIPX
|
10.7 | IC50 | 4 | — | |
OULORHJOSYJPAD
|
10.7 | IC50 | 4 | — | |
WCQVVINBTJFFGB
|
10.7 | IC50 | 4 | — | |
OXZQZNRYJXBLDP
|
10.7 | IC50 | 4 | — | |
RZVBCGFEXPDAAN
|
10.7 | IC50 | 4 | — | |
UXRAMPPWHJVSRI
|
10.7 | IC50 | 4 | — | |
ZAKXPDYMSATSNV
|
10.7 | IC50 | 4 | — | |
DUCVKLWZWGMVAG
|
10.7 | IC50 | 4 | — | |
XSNARVIBTBLTRJ
|
10.7 | IC50 | 3 | — | |
LTGGHOLQJAWCLY
|
10.7 | IC50 | 4 | — | |
PMOCYAUOLYFXTN
|
10.7 | IC50 | 4 | — | |
SRPNJZWTHJDMHK
|
10.6 | IC50 | 3 | — | |
UCALNVLMEPQUKV
|
10.6 | IC50 | 3 | — | |
LKWGXMHPDZPNBK
|
10.6 | IC50 | 3 | — | |
IWYQGKABFOIXJU
|
10.6 | IC50 | 4 | — | |
UWHIGIGJYWQVAR
|
10.6 | IC50 | 3 | — | |
WPKFVOMIANZVBJ
|
10.6 | IC50 | 4 | — | |
SPBQBLPDYVFLQK
|
10.5 | IC50 | 4 | — | |
MECRHGTYHNILSM
|
10.5 | IC50 | 2 | — | |
PAAXNRZNSVJLOA
|
10.5 | IC50 | 2 | — | |
TWGKDJAUEJWZFH
|
10.5 | IC50 | 2 | — | |
UVPYTQJXGJPHTJ
|
10.5 | IC50 | 2 | — | |
ZSDGWXOXHFFBFW
|
10.5 | IC50 | 2 | — | |
LRJHFOMJPOSHDU
|
10.5 | IC50 | 4 | — | |
IOVFFTMQWCOHDE
|
10.5 | Ki | 4 | — | |
MNJZYSVSFNQWBL
|
10.5 | IC50 | 4 | — |