Target Details
| UniProt AC | P23458 |
|---|---|
| Gene Symbol | JAK1 |
| Protein Name | Tyrosine-protein kinase JAK1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF18379 (FERM_F1) PF18377 (FERM_F2) PF17887 (Jak1_Phl) PF07714 (PK_Tyr_Ser-Thr) PF21990 (SH2_1) |
Summary
- Multi-target molecules 8,920
- Clinical molecules 14
- Avg pChEMBL 8.26
KEGG Pathways (28)
- Coronavirus disease - COVID-19
- EGFR tyrosine kinase inhibitor resistance
- Epstein-Barr virus infection
- Hepatitis B
- Hepatitis C
- Herpes simplex virus 1 infection
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Influenza A
- JAK-STAT signaling pathway
- Kaposi sarcoma-associated herpesvirus infection
- Leishmaniasis
- Measles
- NOD-like receptor signaling pathway
- Necroptosis
- Osteoclast differentiation
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Signaling pathways regulating pluripotency of stem cells
- Th1 and Th2 cell differentiation
- Th17 cell differentiation
- Toll-like receptor signaling pathway
- Toxoplasmosis
- Tuberculosis
- Viral carcinogenesis
Associated Diseases (1)
Active Molecules (8,920)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
NCZZXIYJRYNEAO
|
11.9 | IC50 | 3 | — | |
PLALKTRHBMUZHB
|
11.9 | IC50 | 3 | — | |
KFPFHFNFCCTGOO
|
11.7 | IC50 | 4 | — | |
QMHIFZZTSBMKGF
|
11.7 | IC50 | 3 | — | |
RKDYFKWEFAJOHF
|
11.7 | IC50 | 4 | — | |
BCMIRTHEUWYNHX
|
11.5 | IC50 | 4 | — | |
BNOPEBHGDTWAQX
|
11.5 | IC50 | 4 | — | |
LNTSTFPYHHHPLZ
|
11.5 | IC50 | 4 | — | |
XUBODOZNSMBJOD
|
11.5 | IC50 | 4 | — | |
JYSFPYSVGWPCBC
|
11.4 | IC50 | 4 | — | |
NDKIFWJDZDKTCC
|
11.4 | IC50 | 4 | — | |
ACXRPKBVTFNUBE
|
11.3 | IC50 | 4 | — | |
AJSTYWNQMVMSLL
|
11.3 | IC50 | 3 | — | |
FPLDLCFSEQHYEF
|
11.3 | IC50 | 4 | — | |
FUEIJOICQSRCFR
|
11.3 | IC50 | 4 | — | |
LWEXBVKOJGMKLH
|
11.3 | IC50 | 4 | — | |
NWGRIRNDHVPEDQ
|
11.3 | IC50 | 4 | — | |
PMCNHBRGNUQKHF
|
11.3 | IC50 | 4 | — | |
QIUJVZGYISFYIX
|
11.3 | IC50 | 3 | — | |
SCFXRVXGXNBVDI
|
11.3 | IC50 | 3 | — | |
GYZPAKVHBCQCKK
|
11.3 | IC50 | 3 | — | |
NRYOXXMMQVNECT
|
11.3 | IC50 | 4 | — | |
AFWJENUAHKAUTF
|
11.2 | IC50 | 4 | — | |
IRIDDEHSOPFQKO
|
11.2 | IC50 | 4 | — | |
LJGKJOABCDCQLE
|
11.2 | IC50 | 4 | — | |
OZDFKECLFIDGPK
|
11.2 | IC50 | 4 | — | |
VTOHXCTUKVQTFB
|
11.2 | IC50 | 4 | — | |
AVRFACACEWCPRC
|
11.2 | IC50 | 4 | — | |
IMJWRPPOQVYHRQ
|
11.2 | IC50 | 4 | — | |
VZMBJDMHDUJNSV
|
11.2 | IC50 | 4 | — | |
FNYKNWAPYCCIQE
|
11.1 | IC50 | 3 | — | |
FLPGRFLJPKNKQT
|
11.1 | IC50 | 4 | — | |
FNVZUMZCEAGHIK
|
11.1 | IC50 | 4 | — | |
GJVBDBDAEXZQHK
|
11.1 | IC50 | 4 | — | |
QWODIMBFQKNKDV
|
11.1 | IC50 | 4 | — | |
UAYHCEIKWIDIQO
|
11.1 | IC50 | 4 | — | |
WRFANJMETRKSFA
|
11.1 | IC50 | 4 | — | |
CZCGCTUNTFUHHU
|
11.1 | IC50 | 4 | — | |
LMJGEGVYXUTLBG
|
11.1 | IC50 | 3 | — | |
MXRGRNIICPTRCZ
|
11.1 | IC50 | 4 | — | |
SPWAURFUZZSOJK
|
11.1 | IC50 | 4 | — | |
ULCSWHXDOWVFMK
|
11.1 | IC50 | 4 | — | |
VLAHIKLMFQZDPR
|
11.1 | IC50 | 4 | — | |
ZNYVCNNRCFFDAF
|
11.1 | IC50 | 4 | — | |
AFIWMJZBAJUSCH
|
11.0 | IC50 | 2 | — | |
CHUJALYWQZENTG
|
11.0 | IC50 | 4 | — | |
BNYRMKQMDQUUAU
|
11.0 | IC50 | 4 | — | |
HQUBADRFDQYRJZ
|
11.0 | IC50 | 4 | — | |
OZDFKECLFIDGPK
|
11.0 | IC50 | 4 | — | |
UWCJNDNJYBLIQE
|
11.0 | IC50 | 4 | — |