Target Details
| UniProt AC | P23443 |
|---|---|
| Gene Symbol | RPS6KB1 |
| Protein Name | Ribosomal protein S6 kinase beta-1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) PF00433 (Pkinase_C) |
Summary
- Multi-target molecules 1,180
- Clinical molecules 27
- Avg pChEMBL 7.62
KEGG Pathways (31)
- AMPK signaling pathway
- Acute myeloid leukemia
- Apelin signaling pathway
- Autophagy - animal
- Breast cancer
- Chemical carcinogenesis - receptor activation
- Choline metabolism in cancer
- Colorectal cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocrine resistance
- ErbB signaling pathway
- Fc gamma R-mediated phagocytosis
- Gastric cancer
- HIF-1 signaling pathway
- Hepatocellular carcinoma
- Human cytomegalovirus infection
- Human immunodeficiency virus 1 infection
- Human papillomavirus infection
- Insulin resistance
- Insulin signaling pathway
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- PD-L1 expression and PD-1 checkpoint pathway in cancer
- PI3K-Akt signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Proteoglycans in cancer
- Shigellosis
- TGF-beta signaling pathway
- Thermogenesis
- mTOR signaling pathway
Active Molecules (1,180)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
TUVCZMWCKOCSGF
|
8.5 | IC50 | 2 | — | |
UTOWQUDTUIJADK
|
8.5 | IC50 | 2 | — | |
WDEJLOOXNNKPGL
|
8.5 | IC50 | 2 | — | |
YCUXZFDOLJQXOU
|
8.5 | IC50 | 2 | — | |
AAEAMMIUQZAASJ
|
8.5 | IC50 | 3 | — | |
AFYUEMPQCUBPIM
|
8.5 | IC50 | 2 | — | |
DHNWCWGJFSTRBB
|
8.5 | IC50 | 3 | — | |
FMWDLKYEDOLKPS
|
8.5 | IC50 | 2 | — | |
GDBKJDBGCLFSGA
|
8.5 | IC50 | 4 | — | |
KAWNIHAFIANXQO
|
8.5 | IC50 | 2 | — | |
XBXIODDCUMBUKP
|
8.5 | IC50 | 2 | — | |
ZBAAWCIEXLKIOX
|
8.5 | IC50 | 2 | — | |
HUDQBWLADGWETM
|
8.4 | IC50 | 4 | — | |
IVDPKGQKEFWOHL
|
8.4 | IC50 | 2 | — | |
OKYNDJYJBCXEFE
|
8.4 | IC50 | 2 | — | |
YHHQDNHWBSOPCY
|
8.4 | IC50 | 2 | — | |
KNMURETUMRHPHG
|
8.4 | IC50 | 2 | — | |
MCLSMBVMAJFHIH
|
8.4 | IC50 | 2 | — | |
OQRKWAUIOFYDTC
|
8.4 | IC50 | 2 | — | |
OXHFPLUADZAODN
|
8.4 | IC50 | 2 | — | |
PJXZRSDPJPHIOH
|
8.4 | IC50 | 4 | — | |
SICPNVSSMIOAEC
|
8.4 | IC50 | 3 | — | |
KFUGVCOVSKGHMS
|
8.4 | IC50 | 2 | — | |
KPWXHZUYRNURPQ
|
8.4 | IC50 | 2 | — | |
NTOBVYZGGUJDBU
|
8.4 | IC50 | 2 | — | |
PNEGFSYBATWTOZ
|
8.4 | IC50 | 2 | — | |
WVTHMUMKIIXBSD
|
8.4 | IC50 | 2 | — | |
FQHMWPOPJGVXKJ
|
8.4 | IC50 | 2 | — | |
KGWZPNJXJGFYKW
|
8.4 | IC50 | 2 | — | |
MFRRIEBIBJQMAF
|
8.4 | IC50 | 3 | — | |
TYPKAXVMTXNHHJ
|
8.4 | IC50 | 2 | — | |
UZJADKTVPXXGSB
|
8.4 | IC50 | 2 | — | |
AADMVMUUAFAHRV
|
8.4 | IC50 | 2 | — | |
ASONMRWYCJVKFA
|
8.4 | IC50 | 2 | — | |
BTHYNSZFAHGSOX
|
8.4 | IC50 | 4 | — | |
FYXRSVDHGLUMHB
|
8.4 | IC50 | 8 | — | |
IHGUHCPMDSTTIW
|
8.4 | Ki | 5 | — | |
LBTKEPYWOLJQQB
|
8.4 | IC50 | 2 | — | |
LJMKRAKDJVPMIO
|
8.4 | IC50 | 3 | — | |
OUUVYLIHKQEWSG
|
8.4 | IC50 | 2 | — | |
POBKWGYBFDTZBY
|
8.4 | IC50 | 2 | — | |
QVNJMAZNLWULFC
|
8.4 | IC50 | 2 | — | |
VRAXDMMWMCJWST
|
8.4 | IC50 | 2 | — | |
YOPFBPOFMONRKA
|
8.4 | Ki | 4 | — | |
ZYVZIIOEQZQPSX
|
8.4 | IC50 | 2 | — | |
BMYPGRZADREWCU
|
8.4 | IC50 | 3 | — | |
JMHMGIHHTONCMK
|
8.4 | IC50 | 2 | — | |
JVEJLBKQFMZNTL
|
8.4 | IC50 | 2 | — | |
QEBKTAPIPPPLOK
|
8.4 | IC50 | 2 | — | |
VTUZZITVYRIKEE
|
8.4 | IC50 | 2 | — |