Target Details
| UniProt AC | P22694 |
|---|---|
| Gene Symbol | PRKACB |
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 121
- Clinical molecules 37
- Avg pChEMBL 7.18
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (121)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AXRCEOKUDYDWLF
|
6.2 | Kd | 31 | — | |
HJFKANRRGGLIMD
|
6.2 | IC50 | 4 | — | |
KJGUOQMSLKZPAT
|
6.2 | IC50 | 17 | Yes | |
PKQJCYXKRNGUKQ
|
6.2 | IC50 | 6 | — | |
KJCKVXKGXLPESD
|
6.1 | Ki | 3 | — | |
KJCKVXKGXLPESD
|
6.1 | Ki | 3 | — | |
HPBJQOWLAKYNDM
|
6.1 | IC50 | 15 | Yes | |
MQCCJEYZKWZQHU
|
6.1 | IC50 | 15 | Yes | |
JEFRBITWIOXMNQ
|
6.1 | IC50 | 6 | — | |
XYUFCXJZFZPEJD
|
6.1 | IC50 | 9 | — | |
JMYQFLAMZXRYGY
|
6.1 | IC50 | 6 | Yes | |
YPDLMDMBCACZDE
|
6.1 | IC50 | 8 | Yes | |
LOLPPWBBNUVNQZ
|
6.0 | Kd | 97 | Yes | |
QYEKPILGAVXHQH
|
6.0 | IC50 | 5 | — | |
PHEMXOLLNFYYLK
|
6.0 | IC50 | 8 | Yes | |
GGQAEINRBKFRGZ
|
6.0 | IC50 | 15 | Yes | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
KHVVJKLNKLQLJZ
|
6.0 | IC50 | 288 | — | |
MAHFVAHPQSLLJF
|
6.0 | IC50 | 288 | — | |
NRSGWEVTVGZDFC
|
6.0 | IC50 | 50 | — | |
VBPYLWZBNRFLEM
|
6.0 | IC50 | 4 | — |