Target Details
| UniProt AC | P22694 |
|---|---|
| Gene Symbol | PRKACB |
| Protein Name | cAMP-dependent protein kinase catalytic subunit beta |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00069 (Pkinase) |
Summary
- Multi-target molecules 121
- Clinical molecules 37
- Avg pChEMBL 7.18
KEGG Pathways (72)
- Adrenergic signaling in cardiomyocytes
- Alcoholism
- Aldosterone synthesis and secretion
- Amoebiasis
- Amphetamine addiction
- Apelin signaling pathway
- Autophagy - animal
- Bile secretion
- Calcium signaling pathway
- Chemical carcinogenesis - receptor activation
- Chemokine signaling pathway
- Cholinergic synapse
- Circadian entrainment
- Cocaine addiction
- Cortisol synthesis and secretion
- Cushing syndrome
- Dilated cardiomyopathy
- Dopaminergic synapse
- Endocrine and other factor-regulated calcium reabsorption
- Endocrine resistance
- Estrogen signaling pathway
- GABAergic synapse
- Gap junction
- Gastric acid secretion
- Glucagon signaling pathway
- Glutamatergic synapse
- GnRH signaling pathway
- Growth hormone synthesis, secretion and action
- Hedgehog signaling pathway
- Hormone signaling
- Human T-cell leukemia virus 1 infection
- Human cytomegalovirus infection
- Human papillomavirus infection
- Inflammatory mediator regulation of TRP channels
- Insulin secretion
- Insulin signaling pathway
- Long-term potentiation
- Longevity regulating pathway
- Longevity regulating pathway - multiple species
- MAPK signaling pathway
- Melanogenesis
- Morphine addiction
- Neuroactive ligand signaling
- Olfactory transduction
- Oocyte meiosis
- Ovarian steroidogenesis
- Oxytocin signaling pathway
- Parathyroid hormone synthesis, secretion and action
- Parkinson disease
- Pathways in cancer
- Platelet activation
- Prion disease
- Progesterone-mediated oocyte maturation
- Proteoglycans in cancer
- Ras signaling pathway
- Regulation of lipolysis in adipocytes
- Relaxin signaling pathway
- Renin secretion
- Retrograde endocannabinoid signaling
- Salivary secretion
- Serotonergic synapse
- Taste transduction
- Thermogenesis
- Thyroid hormone signaling pathway
- Thyroid hormone synthesis
- Tight junction
- Vascular smooth muscle contraction
- Vasopressin-regulated water reabsorption
- Vibrio cholerae infection
- Viral carcinogenesis
- Wnt signaling pathway
- cAMP signaling pathway
Associated Diseases (1)
Active Molecules (121)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
HHOVRZGUSBMKKU
|
10.0 | IC50 | 9 | — | |
LBRNKEMUALCIHZ
|
10.0 | Kd | 4 | — | |
KYCYRGUYNYCBAH
|
9.0 | IC50 | 7 | — | |
SOGKOUURZPAQPP
|
9.0 | IC50 | 6 | — | |
LHQWPYOYDRVMFI
|
8.7 | IC50 | 10 | Yes | |
HFBCKXXEXNDPEJ
|
8.7 | IC50 | 5 | — | |
PUQFAZBAPCKZKN
|
8.6 | IC50 | 5 | — | |
WSQSTYRDZFLOBK
|
8.6 | IC50 | 3 | — | |
SNUDLLACDRMNDB
|
8.6 | IC50 | 6 | — | |
MWKSRKSEWLRPBL
|
8.5 | Kd | 1075 | — | |
OFPFIAWWDTYSBZ
|
8.5 | Ki | 15 | Yes | |
JHKZENPNLYAVCT
|
8.5 | IC50 | 15 | Yes | |
UMQNZSBIZJEBSD
|
8.4 | IC50 | 6 | — | |
KPJDEGAKXAUVAC
|
8.4 | Ki | 15 | Yes | |
XYUFCXJZFZPEJD
|
8.3 | Ki | 23 | Yes | |
KLSYPIQWMFSSJW
|
8.3 | IC50 | 8 | — | |
YBFUTVSSQNLDCI
|
8.3 | IC50 | 4 | — | |
VUTDBZFATUOXQL
|
8.3 | IC50 | 6 | — | |
DRRUMZPUGPNKLX
|
8.3 | IC50 | 5 | — | |
PQVIVJUHYDLYRA
|
8.2 | IC50 | 6 | — | |
ZWPLUYQDKWPRGX
|
8.2 | IC50 | 4 | — | |
QSSKKSGGXPWDPC
|
8.2 | IC50 | 5 | — | |
YHOBLDNPLJTSDM
|
8.2 | IC50 | 4 | — | |
OARXLGLBMAHALM
|
8.1 | IC50 | 12 | Yes | |
HKSZLNNOFSGOKW
|
8.1 | IC50 | 408 | — | |
ZNQFWMICKJTIBV
|
8.1 | IC50 | 4 | — | |
KGPGFQWBCSZGEL
|
7.9 | Kd | 59 | Yes | |
UMTWTCVTRDYHQQ
|
7.9 | IC50 | 4 | — | |
IIRWNGPLJQXWFJ
|
7.8 | Kd | 21 | — | |
BNFMNOMUDQORMA
|
7.8 | IC50 | 4 | — | |
WHPGUDAVAIYVRR
|
7.8 | IC50 | 4 | — | |
XXBKLDUYHYSMNJ
|
7.8 | IC50 | 4 | — | |
GIPRMCJMIWRNNH
|
7.8 | IC50 | 4 | — | |
GQEPXNDANQTLHI
|
7.8 | IC50 | 4 | — | |
NVSJOASGKCGXBZ
|
7.7 | IC50 | 16 | Yes | |
UMDIEKHQTFPTBH
|
7.7 | IC50 | 6 | — | |
UXIGAYGUDGBPOS
|
7.6 | IC50 | 6 | — | |
ZCVGUOHAEJQFRY
|
7.6 | IC50 | 6 | — | |
POTTVLREWUNNRO
|
7.6 | IC50 | 17 | Yes | |
HKSZLNNOFSGOKW
|
7.5 | Kd | 213 | — | |
IRGJDPZJEUYSKS
|
7.5 | IC50 | 9 | — | |
IRGJDPZJEUYSKS
|
7.5 | IC50 | 9 | — | |
BJQFSJIVYSQLSX
|
7.5 | IC50 | 4 | — | |
QVZTZUQJFINWOX
|
7.5 | IC50 | 4 | — | |
HPWBHQIUIBFTQC
|
7.5 | IC50 | 4 | — | |
SGHXFHRRWFLILP
|
7.4 | IC50 | 8 | — | |
ZAMACYCHJDCXFC
|
7.3 | IC50 | 4 | — | |
PQHAJHBMGVFBAP
|
7.3 | IC50 | 4 | — | |
AXTAPYRUEKNRBA
|
7.3 | Kd | 24 | — | |
HLXIFVDYTGEUJV
|
7.3 | IC50 | 15 | Yes |