Target Details
| UniProt AC | P22607 |
|---|---|
| Gene Symbol | FGFR3 |
| Protein Name | Fibroblast growth factor receptor 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21165 (FGFR3_TM) PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,742
- Clinical molecules 64
- Avg pChEMBL 7.75
KEGG Pathways (13)
- Bladder cancer
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- MAPK signaling pathway
- MicroRNAs in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (15)
- Achondroplasia
- Bladder cancer
- CATSHL syndrome
- Colorectal cancer
- Crouzon syndrome
- Epidermal nevus
- FGFR3-related short limb skeletal dysplasia
- Hypochondroplasia
- Lacrimo-auriculo-dento-digital syndrome
- Muenke syndrome
- Multiple myeloma
- SADDAN
- Syndromic craniosynostoses
- Testicular cancer
- Thanatophoric dysplasia
Active Molecules (2,742)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
WBNZLXIVFORDRO
|
8.6 | IC50 | 4 | — | |
XFZJRMKUNDQXMW
|
8.6 | IC50 | 5 | — | |
XQNAACXFYIJAFA
|
8.6 | IC50 | 2 | — | |
YMKCMNJQFGEWCA
|
8.6 | IC50 | 8 | Yes | |
BIEQCIXMEKROFP
|
8.6 | IC50 | 5 | — | |
JPJVHSSGRZKSDJ
|
8.6 | IC50 | 5 | — | |
QPQVFVWZSRRLKL
|
8.6 | IC50 | 2 | — | |
QQMCUGWXDVCQJJ
|
8.6 | IC50 | 2 | — | |
CQDRTFWUDOIACC
|
8.6 | IC50 | 5 | — | |
FHSRSKPIXRNREU
|
8.6 | IC50 | 3 | — | |
FMWDLYTVSRVYQS
|
8.6 | IC50 | 5 | — | |
FTKVUQRGSBOXFN
|
8.6 | IC50 | 2 | — | |
KEKXLNDHFOMLPS
|
8.6 | IC50 | 3 | — | |
LKEVQRQSOCDDOH
|
8.6 | IC50 | 2 | — | |
MYFRXSIWRAGTKV
|
8.6 | IC50 | 5 | — | |
NCHRMJWKKXNHAK
|
8.6 | IC50 | 3 | — | |
TXTUOAIWPPOHGN
|
8.6 | IC50 | 2 | — | |
TXTUOAIWPPOHGN
|
8.6 | IC50 | 2 | — | |
UTSJXBMPHBVLAA
|
8.6 | IC50 | 2 | — | |
WWSOBQWYCWXPCN
|
8.6 | IC50 | 2 | — | |
ZLMFMCAAXFMGPC
|
8.6 | IC50 | 2 | — | |
JCQODDIJVHORMY
|
8.5 | IC50 | 5 | — | |
JPESTLPEBJPKGA
|
8.5 | IC50 | 2 | — | |
JQYPWJCACYTKIC
|
8.5 | IC50 | 5 | — | |
ODVWBADYBXDOHC
|
8.5 | IC50 | 3 | — | |
POLNUZKLYNIOKF
|
8.5 | IC50 | 2 | — | |
KFGHIGPSLAQEPJ
|
8.5 | IC50 | 2 | — | |
KUGJFEQBGXQFTH
|
8.5 | IC50 | 2 | — | |
OBIGQHHQWHGMBR
|
8.5 | IC50 | 2 | — | |
OLAHOMJCDNXHFI
|
8.5 | IC50 | 6 | — | |
PKVLWKNKVDXCGO
|
8.5 | IC50 | 2 | — | |
PUIXMSRTTHLNKI
|
8.5 | IC50 | 12 | — | |
QHCGPJPIPKDWAT
|
8.5 | IC50 | 8 | — | |
SISPBNWXCLKBKE
|
8.5 | IC50 | 5 | — | |
FVQGKTSSOVEZPA
|
8.5 | IC50 | 2 | — | |
OAPFSJHTGYLAMA
|
8.5 | IC50 | 2 | — | |
OXOGSNQFCPKZMA
|
8.5 | IC50 | 3 | — | |
PGYHNFZYLXOCCZ
|
8.5 | IC50 | 2 | — | |
XPJZNFSHCZZAQF
|
8.5 | IC50 | 3 | — | |
DJSACWHIHAUSKQ
|
8.5 | IC50 | 3 | — | |
JEDTURAIMNGEAI
|
8.5 | IC50 | 3 | — | |
JIDWYSMCSIWSQL
|
8.5 | IC50 | 5 | — | |
LFIHPORZEBZZHY
|
8.5 | IC50 | 3 | — | |
MJMIZDWOYMOFDX
|
8.5 | IC50 | 3 | — | |
OMHJAMXRVWTRAY
|
8.5 | IC50 | 3 | — | |
TVUWQDLBEOZVOU
|
8.5 | Ki | 41 | — | |
XWRLHVWTHQFHSY
|
8.5 | IC50 | 5 | — | |
JBXLEBAVNPBBTP
|
8.5 | Kd | 3 | — | |
MRSBZNMRJKJWIX
|
8.5 | IC50 | 5 | — | |
QJSDPLBJLHJTJP
|
8.5 | IC50 | 6 | — |