Target Details
| UniProt AC | P22607 |
|---|---|
| Gene Symbol | FGFR3 |
| Protein Name | Fibroblast growth factor receptor 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21165 (FGFR3_TM) PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,742
- Clinical molecules 64
- Avg pChEMBL 7.75
KEGG Pathways (13)
- Bladder cancer
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- MAPK signaling pathway
- MicroRNAs in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (15)
- Achondroplasia
- Bladder cancer
- CATSHL syndrome
- Colorectal cancer
- Crouzon syndrome
- Epidermal nevus
- FGFR3-related short limb skeletal dysplasia
- Hypochondroplasia
- Lacrimo-auriculo-dento-digital syndrome
- Muenke syndrome
- Multiple myeloma
- SADDAN
- Syndromic craniosynostoses
- Testicular cancer
- Thanatophoric dysplasia
Active Molecules (2,742)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
OXJWXQVCCWDQJS
|
8.8 | IC50 | 6 | — | |
QTQBJRCBSLLTBA
|
8.8 | IC50 | 3 | — | |
XALXWJVCZUHIBS
|
8.8 | IC50 | 3 | — | |
XMVITVIKEQWXPB
|
8.8 | IC50 | 5 | — | |
XVBSSIIZNSDEAT
|
8.8 | Kd | 3 | — | |
BFQGJTMYIGHGLT
|
8.8 | IC50 | 5 | — | |
IJNFMKJSNQLEOT
|
8.8 | IC50 | 5 | — | |
LLBFRCVAASUZPB
|
8.7 | IC50 | 2 | — | |
MJBNLVZGJYYOOP
|
8.7 | IC50 | 5 | — | |
MNAZRVJESCCZFQ
|
8.7 | IC50 | 2 | — | |
PQBLTKIKXPKVLI
|
8.7 | IC50 | 2 | — | |
QZUYKKDZNXWNPD
|
8.7 | IC50 | 5 | — | |
VRQMAABPASPXMW
|
8.7 | IC50 | 8 | — | |
WIAGFLYJODEJMC
|
8.7 | IC50 | 2 | — | |
XNRZJGZKJIEPIW
|
8.7 | IC50 | 3 | — | |
ZMSXGEYSNDHGJO
|
8.7 | IC50 | 3 | — | |
MNUGHQYUMFMXIC
|
8.7 | IC50 | 5 | — | |
ABQSJCCISLWTEW
|
8.7 | IC50 | 8 | Yes | |
BAWZESLJEVSFRN
|
8.7 | IC50 | 6 | — | |
BBZNFKRCGVBNLL
|
8.7 | IC50 | 3 | — | |
CTUHAAWNNBQIDY
|
8.7 | IC50 | 4 | — | |
CYOSEXIUDLKBBP
|
8.7 | IC50 | 3 | — | |
HNMFYNZSWBGHHO
|
8.7 | IC50 | 3 | — | |
HYTKNUZBKDBMMN
|
8.7 | IC50 | 5 | — | |
LDQGEOUVYHURBX
|
8.7 | IC50 | 2 | — | |
MCJDCDKCTQBUDW
|
8.7 | IC50 | 2 | — | |
MEEJXBYUJRNZGM
|
8.7 | IC50 | 3 | — | |
NVWPJAMSFZHMRS
|
8.7 | IC50 | 3 | — | |
PGLZJHICUYCCJE
|
8.7 | IC50 | 7 | — | |
SDTAEHMYBHWTDK
|
8.7 | IC50 | 8 | Yes | |
VJCMHZAWAQENNZ
|
8.7 | IC50 | 2 | — | |
YLMMYYCOZCUKKA
|
8.7 | IC50 | 5 | — | |
ZWHKWOQATUSJSR
|
8.7 | IC50 | 3 | — | |
GLLVJFAKHOOPKT
|
8.7 | IC50 | 5 | — | |
KPBLASRJMVBLEW
|
8.7 | IC50 | 3 | — | |
NIKUTJUSYMUTDM
|
8.7 | IC50 | 2 | — | |
QTGVMULYBGRVHT
|
8.7 | IC50 | 5 | — | |
SNHBGFVTNCKJMW
|
8.7 | IC50 | 2 | — | |
VDZZYOJYLLNBTD
|
8.7 | IC50 | 4 | — | |
AABHAFTYFDHGCT
|
8.7 | IC50 | 2 | — | |
IGZKSXILFWECCS
|
8.7 | IC50 | 3 | — | |
WZRAHVCKWICVFZ
|
8.7 | IC50 | 3 | — | |
XLNGMFTYBBUTJH
|
8.7 | IC50 | 2 | — | |
XNMAPUNKOCMYMH
|
8.7 | IC50 | 4 | — | |
YLUAUDRMSFJFJJ
|
8.7 | IC50 | 4 | — | |
QCVAKADHFHWSIV
|
8.7 | IC50 | 2 | — | |
ZZHXBVAGIWPPJN
|
8.7 | IC50 | 2 | — | |
BHTIIMSZAXKDLF
|
8.6 | IC50 | 2 | — | |
JJFTZPWALKRXBH
|
8.6 | IC50 | 2 | — | |
PHRHRITUXCQCKS
|
8.6 | IC50 | 2 | — |