Target Details
| UniProt AC | P22607 |
|---|---|
| Gene Symbol | FGFR3 |
| Protein Name | Fibroblast growth factor receptor 3 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF21165 (FGFR3_TM) PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,742
- Clinical molecules 64
- Avg pChEMBL 7.75
KEGG Pathways (13)
- Bladder cancer
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- MAPK signaling pathway
- MicroRNAs in cancer
- PI3K-Akt signaling pathway
- Pathways in cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (15)
- Achondroplasia
- Bladder cancer
- CATSHL syndrome
- Colorectal cancer
- Crouzon syndrome
- Epidermal nevus
- FGFR3-related short limb skeletal dysplasia
- Hypochondroplasia
- Lacrimo-auriculo-dento-digital syndrome
- Muenke syndrome
- Multiple myeloma
- SADDAN
- Syndromic craniosynostoses
- Testicular cancer
- Thanatophoric dysplasia
Active Molecules (2,742)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AKXGEYBQTHJGSZ
|
10.0 | IC50 | 2 | — | |
CXJITJGGCTWHEG
|
10.0 | IC50 | 3 | — | |
CUUBVEXZVSAYPH
|
9.7 | IC50 | 2 | — | |
KXKRDLMFFZNYPD
|
9.7 | IC50 | 2 | — | |
NSZYKHCVXAXWHM
|
9.7 | IC50 | 2 | — | |
SENVOZNIDWYYED
|
9.7 | IC50 | 4 | — | |
XGJBIMKIGAOMPJ
|
9.7 | IC50 | 3 | — | |
LHWABYLWRJNIIY
|
9.6 | IC50 | 7 | — | |
GYXODBZTJVUDOH
|
9.5 | IC50 | 4 | — | |
LBKNXKHZVKUMAV
|
9.5 | IC50 | 2 | — | |
VDTUZTRVIPIQEC
|
9.5 | Kd | 3 | — | |
YLXCHDHMROIYKA
|
9.4 | Kd | 3 | — | |
CERLJSLIKVDHSK
|
9.4 | IC50 | 2 | — | |
VYULPLQTNFKWPI
|
9.4 | IC50 | 2 | — | |
JBXLEBAVNPBBTP
|
9.3 | Kd | 3 | — | |
QUAQGKRFOJCSLY
|
9.3 | IC50 | 2 | — | |
IOBIYPOWMPSWPL
|
9.3 | IC50 | 2 | — | |
WWGLOQFMJUZFTJ
|
9.3 | IC50 | 8 | — | |
UFAUAMOQXHAVJE
|
9.3 | IC50 | 2 | — | |
UXYDXGKJWBUZOQ
|
9.3 | IC50 | 4 | — | |
AKNCKKKGJAAVEH
|
9.3 | IC50 | 2 | — | |
FVBNNGBLKUMCEF
|
9.3 | IC50 | 3 | — | |
MXSDIGYURCYKOV
|
9.3 | IC50 | 5 | — | |
NZYVQKUNDWKOTA
|
9.3 | IC50 | 4 | — | |
XSFHSBDHUMMKQC
|
9.3 | IC50 | 4 | — | |
ZJRVNNZFLXDMBL
|
9.3 | IC50 | 2 | — | |
KEIPNCCJPRMIAX
|
9.3 | IC50 | 5 | — | |
NWFHDWLGIMCVRK
|
9.3 | Kd | 3 | — | |
ZHPKPYDZUXNOSG
|
9.3 | IC50 | 2 | — | |
OTKLUCRKMMCDGK
|
9.3 | IC50 | 2 | — | |
VXGJUTSAHAFGCE
|
9.3 | IC50 | 2 | — | |
YBVLJFZBRWBLPQ
|
9.3 | IC50 | 2 | — | |
DIHKHDKCPLEBJZ
|
9.3 | IC50 | 2 | — | |
LDAQJIOPNUEWIZ
|
9.3 | IC50 | 2 | — | |
MRSOJHDLCLHTOL
|
9.3 | IC50 | 5 | — | |
MPFJYMLAUUROEX
|
9.2 | IC50 | 2 | — | |
GGNLVHVSLAECJE
|
9.2 | IC50 | 2 | — | |
MIVJAOKRYGLYFY
|
9.2 | IC50 | 2 | — | |
VWHPBSPJZJUNFB
|
9.2 | IC50 | 2 | — | |
YWDKSGWRKAMORO
|
9.2 | IC50 | 5 | — | |
GGNLVHVSLAECJE
|
9.2 | IC50 | 2 | — | |
AKNCKKKGJAAVEH
|
9.2 | IC50 | 2 | — | |
LDRFHQAHQFHHDQ
|
9.2 | IC50 | 2 | — | |
NZHANKJSPAJGFW
|
9.2 | IC50 | 4 | — | |
QRSKATROTXSCAH
|
9.2 | IC50 | 2 | — | |
UZZUQDLJRHRISA
|
9.2 | Kd | 3 | — | |
DGIVCIPUNPRUQJ
|
9.2 | IC50 | 2 | — | |
DGIVCIPUNPRUQJ
|
9.2 | IC50 | 2 | — | |
INWHLZUNIJSPHA
|
9.2 | IC50 | 5 | — | |
JUJFWVRSWRTUNC
|
9.2 | IC50 | 2 | — |