Target Details
| UniProt AC | P22309 |
|---|---|
| Gene Symbol | UGT1A1 |
| Protein Name | UDP-glucuronosyltransferase 1A1 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF00201 (UDPGT) |
Summary
- Multi-target molecules 3
- Clinical molecules 0
- Avg pChEMBL 6.08
KEGG Pathways (13)
- Ascorbate and aldarate metabolism
- Bile secretion
- Biosynthesis of cofactors
- Chemical carcinogenesis - DNA adducts
- Chemical carcinogenesis - receptor activation
- Drug metabolism - cytochrome P450
- Drug metabolism - other enzymes
- Metabolic pathways
- Metabolism of xenobiotics by cytochrome P450
- Pentose and glucuronate interconversions
- Porphyrin metabolism
- Retinol metabolism
- Steroid hormone biosynthesis
Associated Diseases (4)
Active Molecules (3)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
AXRYRYVKAWYZBR
|
6.2 | IC50 | 6 | — | |
KAZSKMJFUPEHHW
|
6.0 | IC50 | 2 | — | |
SUXRXYKUAHNUAX
|
6.0 | IC50 | 2 | — |