Target Details
| UniProt AC | P21802 |
|---|---|
| Gene Symbol | FGFR2 |
| Protein Name | Fibroblast growth factor receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,130
- Clinical molecules 64
- Avg pChEMBL 7.82
KEGG Pathways (13)
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Gastric cancer
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (12)
- Antley-Bixler syndrome
- Apert syndrome
- Beare-Stevenson syndrome
- Bent bone dysplasia syndrome
- Crouzon syndrome
- Gastric cancer
- Jackson-Weiss syndrome
- Lacrimo-auriculo-dento-digital syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome
- Scaphocephaly, maxillary retrusion, and impaired intellectual development
- Syndromic craniosynostoses
Active Molecules (2,130)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
QAXDRNRWTCRTHG
|
8.7 | IC50 | 2 | — | |
RIDLANJMTSBUSD
|
8.7 | IC50 | 5 | — | |
RMPLDNDYWZJAKD
|
8.7 | IC50 | 2 | — | |
SDTAEHMYBHWTDK
|
8.7 | IC50 | 8 | Yes | |
XORAFTFBTLPFEB
|
8.7 | IC50 | 3 | — | |
YJAREBGBTVFDIK
|
8.7 | IC50 | 5 | — | |
YMOZRWRCLHRNMF
|
8.7 | IC50 | 3 | — | |
ZRJOWLUBZFAUCV
|
8.7 | IC50 | 5 | — | |
HJJBUHHTOHQWIR
|
8.7 | IC50 | 4 | — | |
LKMLECIRYJPQOC
|
8.7 | IC50 | 5 | — | |
ZAGOLYGHOPAHBL
|
8.7 | IC50 | 5 | — | |
MNWKGVNSRZEIGC
|
8.7 | IC50 | 5 | — | |
MUWNBQMOGBRDAG
|
8.7 | IC50 | 2 | — | |
YOPGGAOPPHWDEP
|
8.7 | IC50 | 5 | — | |
ZGLWZSSPPSSMRB
|
8.7 | IC50 | 5 | — | |
ZSVPKBPPMKNPBR
|
8.7 | IC50 | 5 | — | |
HIRADXZLYXUWGK
|
8.7 | IC50 | 4 | — | |
IVQXFJNVCKJIHX
|
8.7 | IC50 | 5 | — | |
NDBQZKMZTGYUBQ
|
8.7 | IC50 | 5 | — | |
QBQDRJRWFJDCET
|
8.7 | IC50 | 5 | — | |
QSZLOMZJWAOHPQ
|
8.7 | IC50 | 5 | — | |
ZPVPDGPTDITPGD
|
8.7 | IC50 | 5 | — | |
BQBUDKYPYIHTHV
|
8.7 | IC50 | 2 | — | |
DSFNDCSGZPQFHC
|
8.7 | IC50 | 2 | — | |
HGUFBZQRVSFTRA
|
8.7 | IC50 | 2 | — | |
MLGJITMGHIKNFO
|
8.7 | IC50 | 3 | — | |
MOCIDOAKXWFCQL
|
8.7 | IC50 | 3 | — | |
ODRNQGSZGLHVGG
|
8.7 | IC50 | 5 | — | |
SFTIXUFSFGSGJT
|
8.7 | IC50 | 5 | — | |
UTHRHKGJHFUFBP
|
8.7 | IC50 | 4 | — | |
VGVUCVKLHHCRRJ
|
8.7 | IC50 | 5 | — | |
VJRPDSCCZRPRJC
|
8.7 | IC50 | 4 | — | |
VQCLOXLEVFZMAT
|
8.7 | IC50 | 4 | — | |
XFZJRMKUNDQXMW
|
8.7 | IC50 | 5 | — | |
YLXCHDHMROIYKA
|
8.7 | Kd | 3 | — | |
DYLLHXRSSYZCKB
|
8.7 | IC50 | 5 | — | |
HRADXFDASOBMPX
|
8.7 | IC50 | 5 | — | |
KZQKVIAPRMQHBQ
|
8.7 | IC50 | 5 | — | |
MRHQRDLYXUJURF
|
8.7 | IC50 | 5 | — | |
RBMGDJLZTRNYAX
|
8.7 | IC50 | 5 | — | |
UUDVUWYNTAVVOY
|
8.7 | IC50 | 5 | — | |
DKPRRWQOKOGPLV
|
8.6 | IC50 | 2 | — | |
DNVFTXQYIYFQBW
|
8.6 | IC50 | 4 | — | |
IUNZJOJKNTUAGY
|
8.6 | IC50 | 5 | — | |
IWWFPZKWURVISH
|
8.6 | IC50 | 5 | — | |
OLAHOMJCDNXHFI
|
8.6 | IC50 | 5 | — | |
ORRNXKQJDVQOSK
|
8.6 | IC50 | 5 | — | |
UMBCDTSTLGNZAT
|
8.6 | IC50 | 3 | — | |
LBGCXBADNLLJIM
|
8.6 | IC50 | 5 | — | |
QPSHGAWQRGEHKV
|
8.6 | IC50 | 5 | — |