Target Details
| UniProt AC | P21802 |
|---|---|
| Gene Symbol | FGFR2 |
| Protein Name | Fibroblast growth factor receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,130
- Clinical molecules 64
- Avg pChEMBL 7.82
KEGG Pathways (13)
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Gastric cancer
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (12)
- Antley-Bixler syndrome
- Apert syndrome
- Beare-Stevenson syndrome
- Bent bone dysplasia syndrome
- Crouzon syndrome
- Gastric cancer
- Jackson-Weiss syndrome
- Lacrimo-auriculo-dento-digital syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome
- Scaphocephaly, maxillary retrusion, and impaired intellectual development
- Syndromic craniosynostoses
Active Molecules (2,130)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
KDKUVYLMPJIGKA
|
6.2 | Kd | 91 | Yes | |
OZIVLFRYSPXXIE
|
6.2 | Kd | 4 | — | |
PSKWUEAQZZDBSQ
|
6.2 | IC50 | 2 | — | |
RMRPQIXURDCIPY
|
6.1 | IC50 | 3 | — | |
JLELABRDIYAKSN
|
6.1 | IC50 | 3 | — | |
BEVLXXFNNRJOIL
|
6.1 | IC50 | 3 | — | |
NNYHIJGVHOAIGK
|
6.1 | IC50 | 4 | Yes | |
RMBOTBYLWKFONE
|
6.1 | IC50 | 4 | — | |
AQKPZURZTABIMB
|
6.1 | IC50 | 3 | — | |
AVMXRPQTEFBJNT
|
6.1 | IC50 | 3 | — | |
CTNPALGJUAXMMC
|
6.1 | Kd | 151 | — | |
CXQHYVUVSFXTMY
|
6.1 | Kd | 154 | — | |
OZBJFHJVSNZQAB
|
6.1 | IC50 | 2 | — | |
SEJGTFPOEJWEGG
|
6.1 | Kd | 149 | — | |
UCSSQROSBFPVKH
|
6.1 | IC50 | 7 | Yes | |
OLEBYGFFTQTCQL
|
6.1 | IC50 | 2 | — | |
RVXVVMLZMQHZHP
|
6.1 | IC50 | 3 | — | |
YIASGWKTQIIDIL
|
6.1 | IC50 | 4 | — | |
YYLKKYCXAOBSRM
|
6.1 | Kd | 191 | — | |
MTKZXWLKXNWRMT
|
6.0 | Kd | 3 | — | |
OKHAMDQBTFJMMY
|
6.0 | Kd | 3 | — | |
KOHAPQKJEAQWMF
|
6.0 | IC50 | 3 | — | |
HHUATYYBFHVSMC
|
6.0 | IC50 | 2 | — | |
JONUUBFCZUAOFY
|
6.0 | IC50 | 10 | — | |
NTEPYVSSXDTWEK
|
6.0 | Kd | 4 | — | |
VNDWQCSOSCCWIP
|
6.0 | IC50 | 39 | Yes | |
DDTIUWSUHLYLSE
|
6.0 | IC50 | 2 | — | |
ZBPLMNKLJHKRJP
|
6.0 | IC50 | 4 | — | |
IVVSBEQDCAZLFY
|
6.0 | IC50 | 333 | — | |
UCQQUALXTHNJFW
|
6.0 | IC50 | 8 | — |