Target Details
| UniProt AC | P21802 |
|---|---|
| Gene Symbol | FGFR2 |
| Protein Name | Fibroblast growth factor receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,130
- Clinical molecules 64
- Avg pChEMBL 7.82
KEGG Pathways (13)
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Gastric cancer
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (12)
- Antley-Bixler syndrome
- Apert syndrome
- Beare-Stevenson syndrome
- Bent bone dysplasia syndrome
- Crouzon syndrome
- Gastric cancer
- Jackson-Weiss syndrome
- Lacrimo-auriculo-dento-digital syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome
- Scaphocephaly, maxillary retrusion, and impaired intellectual development
- Syndromic craniosynostoses
Active Molecules (2,130)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
GQMZTFFTTCUZAW
|
6.4 | IC50 | 8 | Yes | |
HWPCUDFQBWGXQP
|
6.4 | IC50 | 3 | — | |
FLENFHLDGFNBHY
|
6.4 | IC50 | 4 | — | |
NTDPWPKQOCPZDC
|
6.4 | IC50 | 4 | — | |
PIQCTGMSNWUMAF
|
6.4 | Kd | 137 | Yes | |
UTNUSBXULLEVQT
|
6.4 | IC50 | 3 | — | |
YFSUWPQZPZIDFX
|
6.4 | IC50 | 3 | — | |
LNUZUDUZJCMPHB
|
6.4 | IC50 | 4 | — | |
ZVJJERYMYFMJGK
|
6.4 | IC50 | 2 | — | |
MALHOOCRRAELHO
|
6.4 | IC50 | 3 | — | |
IZRLMSOUCGWVLU
|
6.4 | IC50 | 5 | — | |
JFQCLYYHCRNBPV
|
6.4 | IC50 | 5 | — | |
KMTYZQDOEJCKHM
|
6.4 | IC50 | 2 | — | |
HNHDXHDCBKMWAE
|
6.3 | IC50 | 4 | — | |
NCQZCQOEFXNWLZ
|
6.3 | Kd | 2 | — | |
OUJBFEXXSMKZDS
|
6.3 | IC50 | 6 | — | |
UKSRLPIFMWELTO
|
6.3 | IC50 | 3 | — | |
JOOXLOJCABQBSG
|
6.3 | Kd | 139 | — | |
LSQQCCANVRJKTD
|
6.3 | Kd | 3 | — | |
IRKXKBMGTVDZAJ
|
6.3 | IC50 | 3 | — | |
MGZKYOAQVGSSGC
|
6.3 | IC50 | 4 | — | |
NFYOODCIQOKJEY
|
6.3 | IC50 | 4 | — | |
OTTCBLPTHPBEEX
|
6.3 | Ki | 11 | Yes | |
TXEBNKKOLVBTFK
|
6.3 | IC50 | 5 | — | |
FGCIKBFVIMRWHK
|
6.3 | IC50 | 3 | — | |
LJSSZFMVOGZNES
|
6.3 | IC50 | 4 | — | |
VCNXIHMZQZDVFO
|
6.3 | IC50 | 3 | — | |
YZVCRBZTJOHYET
|
6.3 | IC50 | 3 | — | |
DMPRVNCJBAALGL
|
6.3 | IC50 | 2 | — | |
MACKJBHSMLAAGO
|
6.3 | IC50 | 7 | Yes | |
ZWQWTVLDLQPTSW
|
6.3 | IC50 | 4 | — | |
LMZYDQKZHDRDQF
|
6.3 | IC50 | 3 | — | |
PYBWQTZAPUSDQZ
|
6.3 | Kd | 2 | — | |
QVSYXHKHNOYTCB
|
6.3 | IC50 | 4 | — | |
XJVZSZODRVBVGV
|
6.3 | IC50 | 4 | — | |
HRMBERKHYZOZDF
|
6.3 | IC50 | 3 | — | |
UGJRBLLXVVLWNB
|
6.3 | IC50 | 4 | — | |
ZICKVWJPWJUWIN
|
6.2 | IC50 | 3 | — | |
GCIKSSRWRFVXBI
|
6.2 | Kd | 109 | Yes | |
MBWRLLRCTIYXDW
|
6.2 | IC50 | 4 | — | |
SSPYHBZSDDTSFN
|
6.2 | IC50 | 9 | — | |
WINHZLLDWRZWRT
|
6.2 | Kd | 201 | Yes | |
BLONVLGYKLABHO
|
6.2 | IC50 | 2 | — | |
XLFNLJYGUOLEJS
|
6.2 | IC50 | 26 | — | |
GTRUQMSGMBIRPQ
|
6.2 | IC50 | 4 | — | |
LBTXEAWETVRHIF
|
6.2 | IC50 | 3 | — | |
ZIJVLVUPDVUSMA
|
6.2 | IC50 | 2 | — | |
HVEVXOZVOPQEHH
|
6.2 | IC50 | 4 | — | |
UIARLYUEJFELEN
|
6.2 | Kd | 289 | Yes | |
ZZUBLGDLIQYIIE
|
6.2 | IC50 | 3 | — |