Target Details
| UniProt AC | P21802 |
|---|---|
| Gene Symbol | FGFR2 |
| Protein Name | Fibroblast growth factor receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,130
- Clinical molecules 64
- Avg pChEMBL 7.82
KEGG Pathways (13)
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Gastric cancer
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (12)
- Antley-Bixler syndrome
- Apert syndrome
- Beare-Stevenson syndrome
- Bent bone dysplasia syndrome
- Crouzon syndrome
- Gastric cancer
- Jackson-Weiss syndrome
- Lacrimo-auriculo-dento-digital syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome
- Scaphocephaly, maxillary retrusion, and impaired intellectual development
- Syndromic craniosynostoses
Active Molecules (2,130)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
CXTAUXMVPFRKNN
|
6.7 | IC50 | 2 | — | |
AILRADAXUVEEIR
|
6.7 | IC50 | 75 | — | |
CUZNDTRYWVRYQO
|
6.7 | IC50 | 3 | — | |
DIXPDBVWKBKXJG
|
6.7 | IC50 | 3 | — | |
OLOUMDRSRYPAKN
|
6.7 | IC50 | 3 | — | |
RZUSPPRBXWUVRY
|
6.7 | IC50 | 4 | — | |
BESPBINHRRCJFV
|
6.6 | IC50 | 4 | — | |
CPRHXRHXANOZCR
|
6.6 | IC50 | 5 | — | |
FPKUEZLSSIDWJS
|
6.6 | IC50 | 5 | — | |
OTUXEWXWBIXPSF
|
6.6 | IC50 | 3 | — | |
OXSXREVSJHOBMS
|
6.6 | IC50 | 4 | — | |
FDLLZBANGODCSO
|
6.6 | IC50 | 4 | — | |
GOURCRKPQYORGE
|
6.6 | IC50 | 4 | — | |
KIBMUWUZKRLPOM
|
6.6 | IC50 | 4 | — | |
LKYTVIUPGIYMGO
|
6.6 | IC50 | 3 | — | |
NXSJMRCTGYTSTK
|
6.6 | Kd | 200 | — | |
OWZFRMMJYGBTKN
|
6.6 | IC50 | 4 | — | |
WPSQITLDKMIIOJ
|
6.6 | IC50 | 4 | — | |
FAAACDYRHYCCJJ
|
6.6 | IC50 | 3 | — | |
HZBHIKAVOBCWRF
|
6.6 | IC50 | 3 | — | |
PMGQABAWBRKCMZ
|
6.6 | IC50 | 2 | — | |
QQWUGDVOUVUTOY
|
6.6 | Kd | 231 | Yes | |
TXHRQVDKKNZSSO
|
6.6 | IC50 | 4 | — | |
UBLLKTCSEZOWKU
|
6.6 | IC50 | 3 | — | |
HXZKZGJKVZUSRL
|
6.6 | IC50 | 3 | — | |
SJLAAMAKAKHNLF
|
6.6 | IC50 | 2 | — | |
YOHMMSYTAZLPHD
|
6.6 | IC50 | 3 | — | |
VERWOWGGCGHDQE
|
6.6 | IC50 | 23 | — | |
WHWYKJVHWRZOHC
|
6.6 | IC50 | 2 | — | |
BHQZGGSZRHDQFZ
|
6.6 | IC50 | 13 | Yes | |
CGMQSJXTBXHOTH
|
6.6 | IC50 | 9 | — | |
IEWLQUDDCQIINQ
|
6.6 | IC50 | 3 | — | |
UYAYNOCUUTUNCS
|
6.6 | IC50 | 4 | — | |
MADNVMUCLLTMEQ
|
6.6 | IC50 | 2 | — | |
NDFPXCRYULSGKF
|
6.6 | IC50 | 2 | — | |
VCHBCVRCEHYVAE
|
6.6 | IC50 | 4 | — | |
BDMABVNQSRTPAG
|
6.5 | IC50 | 3 | — | |
FIQIEPWFBOWJLF
|
6.5 | IC50 | 4 | — | |
SQMQPCOOUNHONI
|
6.5 | IC50 | 4 | — | |
XYFPWWZEPKGCCK
|
6.5 | IC50 | 34 | — | |
XYFPWWZEPKGCCK
|
6.5 | IC50 | 7 | — | |
IMYLSIBTGYMGSC
|
6.5 | Kd | 3 | — | |
QEOQAZAFSABGFK
|
6.5 | IC50 | 4 | — | |
GYBMGGFXFSFXNL
|
6.5 | IC50 | 3 | — | |
IRNVMUQZQDLZAK
|
6.5 | IC50 | 5 | — | |
PJEPTYCBAHFMAA
|
6.5 | IC50 | 2 | — | |
AKOPMGQQNOSEED
|
6.5 | IC50 | 4 | — | |
AZNQYUXLRNQXFO
|
6.5 | IC50 | 2 | — | |
BSVRVRYBQFKTMV
|
6.5 | IC50 | 3 | — | |
CMVIHPMIVIZZCE
|
6.5 | IC50 | 2 | — |