Target Details
| UniProt AC | P21802 |
|---|---|
| Gene Symbol | FGFR2 |
| Protein Name | Fibroblast growth factor receptor 2 |
| Organism | Homo sapiens |
| Entry Name | |
| Organism Category | Human |
| Pfam Domains | PF07679 (I-set) PF13927 (Ig_3) PF07714 (PK_Tyr_Ser-Thr) |
Summary
- Multi-target molecules 2,130
- Clinical molecules 64
- Avg pChEMBL 7.82
KEGG Pathways (13)
- Calcium signaling pathway
- Central carbon metabolism in cancer
- EGFR tyrosine kinase inhibitor resistance
- Endocytosis
- Gastric cancer
- MAPK signaling pathway
- PI3K-Akt signaling pathway
- Pathways in cancer
- Prostate cancer
- Rap1 signaling pathway
- Ras signaling pathway
- Regulation of actin cytoskeleton
- Signaling pathways regulating pluripotency of stem cells
Associated Diseases (12)
- Antley-Bixler syndrome
- Apert syndrome
- Beare-Stevenson syndrome
- Bent bone dysplasia syndrome
- Crouzon syndrome
- Gastric cancer
- Jackson-Weiss syndrome
- Lacrimo-auriculo-dento-digital syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome
- Scaphocephaly, maxillary retrusion, and impaired intellectual development
- Syndromic craniosynostoses
Active Molecules (2,130)
| InChIKey | pChEMBL | Type | Targets | Clinical | |
|---|---|---|---|---|---|
FAYFMVHYNQOQRQ
|
6.9 | IC50 | 7 | Yes | |
PVQGRMZRPISVOO
|
6.9 | IC50 | 4 | — | |
RRWSNCZYJCOEFX
|
6.9 | IC50 | 6 | Yes | |
BMVFCJGZPZRJKZ
|
6.9 | IC50 | 2 | — | |
PSJRJLXQWSBSMQ
|
6.9 | IC50 | 3 | — | |
RBNXLWWERIOOGB
|
6.9 | IC50 | 3 | — | |
RZAIWUITRQUFPP
|
6.9 | IC50 | 3 | — | |
FXBPODZDHNYGBT
|
6.9 | IC50 | 3 | — | |
LVEXBQONPVYXPA
|
6.9 | IC50 | 7 | — | |
MCUVUHFGOBRXMR
|
6.9 | IC50 | 4 | — | |
ONSZEUCTVQJHOZ
|
6.8 | IC50 | 9 | — | |
PHGFCPRSBHSCCN
|
6.8 | IC50 | 6 | — | |
QKJLYUUEYRTLCL
|
6.8 | IC50 | 2 | — | |
XTUXOBJKZJZVKD
|
6.8 | IC50 | 4 | Yes | |
HMOQXJKIXKAECO
|
6.8 | IC50 | 4 | — | |
ZIOKWCUGWJTPRO
|
6.8 | IC50 | 5 | — | |
VLBGQZMNQXPCIK
|
6.8 | IC50 | 4 | — | |
BRDWRAQCENICQF
|
6.8 | IC50 | 3 | — | |
FDRRQLZELVDFON
|
6.8 | IC50 | 3 | — | |
IZXXKUVQQOCKPB
|
6.8 | IC50 | 2 | — | |
NAWCLWLCDMKCQJ
|
6.8 | IC50 | 5 | — | |
NLUPPEQIXOCYEE
|
6.8 | IC50 | 5 | — | |
NOZQNRBLSPCZJQ
|
6.8 | IC50 | 4 | — | |
QGAMKOCDVQJIEP
|
6.8 | IC50 | 5 | — | |
UKEJJVHQBBRRLY
|
6.8 | IC50 | 3 | — | |
NGVJHXBKRDWBLJ
|
6.8 | IC50 | 3 | — | |
VERMWPBKJSNHBH
|
6.8 | IC50 | 3 | — | |
AFXUMLYQUOZJJG
|
6.8 | IC50 | 3 | — | |
CIRFKVHYWAUQHV
|
6.8 | IC50 | 3 | — | |
HGUIQKPJMCOQPJ
|
6.8 | IC50 | 4 | — | |
HKRLAZXGSPODSR
|
6.8 | IC50 | 4 | — | |
OXSWGCGZDVCEHI
|
6.8 | IC50 | 4 | — | |
XQSCQYRMPFRFAE
|
6.8 | IC50 | 3 | — | |
CKZSTRXMCOYTCV
|
6.8 | IC50 | 3 | — | |
GEYJBCMVIQPSQS
|
6.8 | IC50 | 4 | — | |
GTVVGKPRDJCRGQ
|
6.8 | IC50 | 3 | — | |
LGGGGQSCTZIUDU
|
6.8 | IC50 | 4 | — | |
XPZIIDDIXMPQBG
|
6.8 | IC50 | 3 | — | |
LFKQSJNCVRGFCC
|
6.8 | IC50 | 6 | — | |
PJJZTYOAUXBVIZ
|
6.8 | IC50 | 2 | — | |
UEFCSGDOOJJXTN
|
6.8 | IC50 | 46 | — | |
UXXQOJXBIDBUAC
|
6.8 | IC50 | 21 | Yes | |
XNXPSFHVHIERHC
|
6.8 | IC50 | 3 | — | |
XRBSCDSDZNBDDK
|
6.8 | IC50 | 3 | — | |
XXGFUXOOCXYEEQ
|
6.8 | IC50 | 5 | — | |
CPKUIFWHMVMECW
|
6.7 | IC50 | 4 | — | |
GCGQJJLZEUBSHE
|
6.7 | IC50 | 2 | — | |
KQWTXAWKBUUOMU
|
6.7 | IC50 | 20 | Yes | |
OOZVKYBZMQSDJS
|
6.7 | IC50 | 3 | — | |
YSROZQPVVLBKFI
|
6.7 | IC50 | 3 | — |